Sucres du squelette et nucléobases

Please enquire for more information about 9-(3-Deoxy-3-fluoro-beta-D-ribofuranosyl)-6-phenylpurine including the price, delivery time and more detailed product information at the technical inquiry form on this page

6-Amino-2-iodopurine is a purine derivative that is used to study hypoxanthines. It can be converted to 2-chloroadenine, which has been shown to cause damage to cells in tissue culture. 6-Amino-2-iodopurine has also been shown to cause sarcomatous transformation of skin cells and the formation of 2-chloroadenosine and 2-aminoadenosine. These compounds are toxic and have been found in damaged DNA. 6-Amino-2-iodopurine also has substituents on the purines, which are damaged when they react with DNA.

Applications 6-Amino-5-nitrouracil (cas# 3346-22-3) is a compound useful in organic synthesis. References Graves, A., et al.: J. Mol. Biol., 377, 914 (2008),

Applications Used in the preparation of pyrrolotriazines.

6-Amino-1-benzyluracil is a triethyl orthoformate that reacts with an aldehyde to form an imine. This reaction is known as alkylation. The imine reacts with benzamidine to form an anticancer drug called lumazine, which has been shown to be effective against cancer cells. 6-Amino-1-benzyluracil had low solubility in water and was therefore refluxed with ethyl acetoacetate and elemental acetoacetate. 6-Amino-1-benzyluracil is insoluble in the organic phase and can be removed by filtration.

2'-Deoxy-5-fluoro-5'-o-[hydroxy(tetradecyloxy)phosphoryl]uridine is a pyrimidine nucleoside that is the active metabolite of 5-fluorouracil. It is an anticancer agent that inhibits tumor cells by blocking their ability to synthesize DNA. 2'-Deoxy-5-fluoro-5'-o-[hydroxy(tetradecyloxy)phosphoryl]uridine has been shown to be safe and effective in clinical trials in mice, but it has not yet been tested in humans. This drug may cause nausea and vomiting when administered intraperitoneally, which may limit its use as an anticancer agent.

Please enquire for more information about 1-[6-(Diethoxyphosphinyl)-2-O-methyl-beta-D-ribo-hexofuranosyl]uracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

2’-C-Methyl-5-fluorouridine is a fine chemical that is used as a versatile building block for the synthesis of various complex compounds. It is also used as a reaction component in the synthesis of research chemicals and speciality chemicals. 2’-C-Methyl-5-fluorouridine is an important intermediate in organic chemistry and has many applications, such as being a reaction component in the synthesis of pharmaceuticals, agrochemicals, dyes, and perfumes.

Adenine phosphate is a molecule that acts as a regulator of endogenous adenosine. It has been shown to inhibit the growth of skin cells in tissue culture and to be effective against influenza virus and other viruses when used in combination with pyridoxine hydrochloride. The molecular weight of adenine phosphate is 314.2 g/mol, corresponding to two nitrogen atoms and four phosphorus atoms. Adenine phosphate is an oxidized form of adenosine triphosphate (ATP) with one phosphate group removed from the molecule. This irreversible oxidation occurs when ATP is exposed to the environment, for example, during tissue culture or viral infection. The effective dose for treating cancer has not yet been determined; however, doses of up to 5 mg/kg are not toxic to mice.

Please enquire for more information about 3’,5’-Di-O-acetyl-2’-deoxy-2’-fluoro-5-iodouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Purine nucleobase; component of nucleic acids and coenzymes

Please enquire for more information about 9N-Trityl guanine including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Bromopurine is an analog of the naturally occurring purine, adenine. It has been shown to be a potent inhibitor of DNA synthesis in both bacterial and mammalian cells. 2-Bromopurine has been shown to react with hydrophobic amino acids, such as methionine and tryptophan, in proteins to form crosslinks that inhibit protein synthesis. 2-Bromopurine is effective against tuberculosis and has been used for the treatment of this disease since the 1950s.

Please enquire for more information about 2’-Deoxy-2’-fluoro-N3-(n-docecyl)uridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6-Chloro-7-deazaadenine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Methyl Green: fluorescent dye, DNA stain, assesses cell viability via microscopy/flow cytometry, peaks at 633/677 nm, light-sensitive storage.

Sofosbuvir is a nucleotide analog that inhibits the hepatitis C virus (HCV) RNA-dependent RNA polymerase and prevents viral replication. Sofosbuvir is an inhibitor of HCV NS5B protein, which is essential for viral replication. Sofosbuvir has been shown to be effective against influenza A virus and picornaviruses in vitro, but not against other RNA viruses such as poliovirus and rhinovirus. It has also been shown to inhibit cancer cell growth in vitro and to inhibit the proliferation of replicating cells in culture. Sofosbuvir has been found to have good oral bioavailability, with a half-life of approximately 2 hours in humans, and can be taken with or without food.

8-Aza-2,6-diaminopurine sulfate (1:x) is a sulfate salt that is soluble in water. The molecular mass of the compound is 581.10 g/mol and it has a molecular formula of C5H7N3O4S. The crystal structure of the compound consists of an asymmetric unit containing one molecule. The 8-aza-2,6-diaminopurine monohydrate salt has a solubility of 1 g/100 mL in water at 25°C. It also has a melting point of 190°C and a boiling point of 340°C.

Please enquire for more information about 5-Hydroxymethyl-2-thiouracil including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Fluoro-1-(4-chlorobenzyl)-uracil is a prodrug that is metabolized to 5-fluorouracol (5FU) in the liver. The drug has been shown to be effective against sarcoma and tumors of mice. The drug was injected subcutaneously into the tumor site, which resulted in a significant reduction of tumor size. Injection of 5-fluoro-1-(4-chlorobenzyl)-uracil also inhibited the growth of tumors in mice by inhibiting DNA synthesis and cell division. It was found that the drug was not toxic to normal tissue cells, suggesting that it may be suitable for use as an anticancer agent.

Cy5 Tyramide, a red dye, amplifies signals in HRP-based immunoassays and nucleic acid hybridization.

CY3-SE: reactive dye for amino-groups in proteins, peptides, DNA. Excitation: 555 nm, Emission: 570 nm.

Please enquire for more information about 9-(2-O-Acetyl-5-O-benzoyl-3-deoxy-3-alpha-C-methyl-beta-D-ribofuranosyl)-6-chloro-9H-purine including the price, delivery time and more detailed product information at the technical inquiry form on this page

6-n-Heptylmercaptopurine is a liquid crystal that has imbricated moieties and pyranosides. It can undergo phase transitions from the isotropic to the mesophase state. 6-n-Heptylmercaptopurine is thermotropic, which means it changes its temperature with respect to the temperature of its surroundings. 6-n-Heptylmercaptopurine is also a bilayer, long chain molecule and it has a monoclinic crystal structure. It is also intercalated in DNA, which may be due to its purine structure.

Purine analog; fluorescent probe; kinase inhibitor; mutagenic