Sucres du squelette et nucléobases

2',3'-Di-O-isopropylidene-5-hydroxymethyl uridine (DIOI) is a fine chemical that can be used as a versatile building block or an intermediate in the research of complex compounds. DIOI is also a useful reagent, which may be used as a starting material for the synthesis of other compounds. It has been shown to have high quality and is available at CAS No. 3816-77-1.

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2’-Deoxy-6-azauridine is a pyrimidine nucleoside that is structurally similar to thymidylate. It has been shown to have antibacterial activity and can be used as an analog for the treatment of tuberculosis. The molecular modeling of 2’-deoxy-6-azauridine shows that it binds to the active site of bacterial enzymes, such as DNA gyrase and thymidylate synthase, which are involved in the synthesis of DNA. This binding prevents the bacterial enzymes from synthesizing DNA and RNA, leading to cell death. 2′-Deoxy-6′-azauridine also inhibits bacterial growth by inhibiting ribonucleotide reductase, which reduces ribonucleotides into deoxyribonucleotides. This inhibition leads to a decrease in dNTPs and an increase in dNMPs, causing a depletion of nucleotides necessary for DNA synthesis and

Intermediate in the synthesis of tipiracil + trifluridine

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Resorufin (NSC-12097) (NSC-12097) is a highly fluorescent pink dye.

AMCA-6-dUTP can be used for enzymatic labeling of DNA/cDNA [1] .

5-(2-Chloroethyl)-2'-fluoroarabinofuranosyluracil is an analog of acyclovir that has been shown to inhibit the growth of uninfected cells. It also has a significant inhibitory effect on simplex virus type 1 and herpes simplex virus type 2. 5-(2-Chloroethyl)-2'-fluoroarabinofuranosyluracil inhibits protein synthesis by inhibiting viral DNA polymerase and the production of ribonucleic acid (RNA). This agent can be used for the treatment of cutaneous or mucosal lesions caused by herpes simplex virus infection.

9-(2-Chloro-6-Fluorobenzyl)-6-Methylaminopurine (9-MP) is an anticoccidial drug that inhibits coccidiosis in birds. It has a wide range of effective dose, which can be administered orally as well as through feed or water. The drug is a purine derivative that is converted to hypoxanthine, xanthine, and uric acid. 9-(2-Chloro-6-Fluorobenzyl)-6-Methylaminopurine also has a role in the life cycle of the parasite by inhibiting gametogenesis. This drug is used as a remedy for tenella infections in poultry and for prevention of coccidiosis in chickens.

Applications 4-Amino-1,3-dimethyl-5-nitrosouracil is a useful building block for organic synthesis.

9-Benzyl-6-chloro-7-deazapurine is an aryl halide that has been used in biomolecular chemistry as an arylation reagent. It reacts with nucleophiles to form covalent bonds. This compound has been used in Suzuki reactions to synthesize heterocycles, such as indoles and benzodiazepines. 9-Benzyl-6-chloro-7-deazapurine is also a halide that can be produced by removing a hydrogen atom from the corresponding alcohol. The functional group of this compound is the phenyl group, which contains a benzene ring and two adjacent carbon atoms. This compound can be catalyzed by acids or bases.

Fluoroethylguanosine is a nucleoside analog that inhibits the enzyme ribonucleotide reductase, which is necessary for the synthesis of DNA. It has been shown to be effective against murine leukemia and other types of cancer cells. Fluoroethylguanosine reacts with guanosine at its 2’-position in an intrastrand cross-link, thereby preventing DNA replication and transcription. This analog also has a high affinity for purines and can form intramolecular crosslinks with p-388 (a protein) as well as other purines such as adenine and hypoxanthine.

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N2-Phenoxyacetyl guanine is a labile nucleoside that can be synthesized by the aminoacylation of guanosine with phenoxyacetic acid. It has been shown to have an important role in oxidative DNA damage, which may lead to mutagenesis and cancer. N2-Phenoxyacetyl guanine is stereoselective and binds preferentially to the GGC sequence, and it is also aminopropylated at its 2′ position. This nucleoside is not ionizing but can be degraded by radiation or enzymes such as deaminases.

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Sulfo-Cyanine7: Enhanced Cy7 analog with 20% better quantum yield, increased photostability for NIR imaging.

7-Deaza-6-hydroxypurine is a skeleton of nucleosides that inhibits enzymes. It has been shown to inhibit the activity of hydrochloric acid, a tumor metastasis promoter. The constant for this drug was determined using molecular modeling and inhibition constants. 7-Deaza-6-hydroxypurine has anticancer activity and can be used for the treatment of cancer. This drug is used as a noncompetitive inhibitor in which it binds to two different sites on the enzyme. It has also been shown to bind to subunits, which are parts of a protein that make up its structure, in biological studies.br> 7-Deaza-6-hydroxypurine is an inhibitor that binds to two different sites on an enzyme. It has been shown to have anticancer activity and can be used for the treatment of cancer. This drug is used as a noncompetitive inhibitor in which it binds to two different sites on the enzyme. It

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3'-Fluoro-2',3'-Dideoxy-5-Iodouridine (3'-FDU) is a nucleoside analog that inhibits the replication of HIV in vitro. 3'-FDU is an analog of uracil and binds to viral RNA, which prevents viral DNA synthesis by blocking the incorporation of nucleotides into the growing strand. The antiviral activity was found to be dose dependent. 3'-FDU showed inhibitory effects on the replication of murine sarcoma virus and guinea pig hepatoma virus in vitro. The effective dose for treatment of HIV infection was found to be 500 micrograms per kilogram body weight. 3'-FDU has also been shown to inhibit RNA synthesis and protein synthesis in human cells infected with murine leukemia virus or human T-cell leukemia virus type 1.

Applications 3-BENZYLADENINE (cas# 7280-81-1) is a useful research chemical.

Guanosine 5'-(gamma-fluorotriphosphate) is a nucleotide that is involved in the hydrolysis of ATP. The catalytic activity of GTPase is an important factor in the activation energy for hydrolysis, which can be determined by kinetic studies. When magnesium ions are added to the reaction solution, the GTPase becomes more active. Guanosine 5'-(gamma-fluorotriphosphate) has been shown to have a constant sedimentation coefficient, which may be due to its hydroxyl group and fluorine atom. This nucleotide has been shown to inhibit guanine nucleotide binding in vitro and this inhibition may be competitively based on postulated models.

5-Iodocytosine (5-IC) is an analog of cytosine that can be used as a precursor for the synthesis of thymine. 5-IC has been shown to cross-couple with DNA, which may contribute to its antiviral potency. 5-IC is also a potent inhibitor of dna replication and herpes simplex virus. The biochemical properties of 5-IC have been extensively studied, including its ability to react with hydrochloric acid to form the corresponding tautomers. The hydrolysis rate increases at higher pH values and decreases at lower pH values. Bioconjugate chemistry has been applied to synthesize a bioconjugated prodrug of 5-IC for cancer treatment.

Cy5.5 dyes label biomolecules for fluorescence imaging and analysis, common in proteins and nucleic acids.

5-Aza-7-deazaguanine (also known as AZA) is an antiviral agent that inhibits viral DNA synthesis by inhibiting the enzyme catalysis of viral DNA polymerase. It is a nucleoside analog that is used to treat herpes simplex virus (HSV). It has also been shown to be effective against other types of viruses, including adenovirus and human papilloma virus. The mechanism of action of 5-Aza-7-deazaguanine relies on its incorporation into the growing DNA chain during replication, which causes misreading of the genetic code. This misreading can lead to premature termination of protein synthesis, resulting in cell death. AZA has also been shown to have cytotoxic effects on tumor cells in tissue culture and cell culture. AZA is a clickable molecule with two reactive groups: an azide and a deaza group. These groups are used for solid-phase synthesis or cross coupling reactions with

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