Sucres du squelette et nucléobases

3-Methyladenine is a glycosylase that cleaves the glycosidic bond between the 3rd and 4th carbon of the ribose ring of the nucleotide 3-methyladenine. It also has synergistic effects with other agents that induce autophagy, such as rapamycin, and increases the expression of a response element in mouse monoclonal antibody. 3-Methyladenine inhibits growth factor-β1 and neuronal death by inducing apoptosis in cells overexpressing nuclear DNA polymerase. This drug is also used to study apoptosis by using a model system.

CY2-SE (Cyanine2 Succinimidyl Ester) is a dye for the labeling of amino-groups in oligonucleotides, peptides, and proteins (Excitation:492 nm, Emission: 510 nm

Cy3, a fluorescent dye, is used for labeling biomolecules and imaging in biological research.

1-(2,3-Dihydroxypropyl)-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione (theophylline) is a bronchodilator and anti-inflammatory agent. It is used to treat asthma and other respiratory conditions. Theophylline is structurally similar to caffeine and theobromine and has been shown to have a similar effect on the heart and blood vessels as these stimulants. It also stimulates the central nervous system in a manner similar to that of theobromine. Theophylline has shown some benefit in congestive heart failure patients but has not been proven effective for treating high blood pressure or fibrillation.

Please enquire for more information about 5-Fluoro-2'-O-Methyl-4-O-(2,4,6-Trimethylphenyl)-Uridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Applications Isotope labelled 5,6-Dihydrothymine is a derivative of Thymine, a nucleobase in the nucleic acid of DNA. 5,6-Dihydrothymine is a radiolysis product of DNA. References Hubbard, K. et al.: Biochemistry, 28, 4382 (1989); Cadet, J. et al.: Int. J. Rad. Biol. Rel. Stud. Phys. Chem. Med., 39, 119 (1981);

2-Chloro-9-methyl-9H-purine is an unmethylated, reactive molecule that can be synthesized through a reaction between piperidine and nucleophilic chloride. It has shown kinetic and kinetic properties, which are reversible reactions that depend on the concentration of reactants. 2-Chloro-9-methyl-9H-purine is able to produce anions such as hydroxide ions when it reacts with anions such as chloride or hydroxide ion. This compound is also able to form heterocycles with other molecules in the presence of methylsulphonyl hydroxide.

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1,3,6-Trimethyl-5-iodouracil (TMIU) is a nucleophile that reacts with electrophiles. It is used as a precursor to the synthesis of other compounds, such as 1,3,6-trimethyluracil. TMIU can be synthesized by chlorinating 6-methyluracil in the presence of a proton source. The reaction time for this synthesis is typically between 30 minutes and 3 hours. The yields are typically around 50%. Carbocations that form during this reaction are an analogous to methyl cations in nucleophilic substitutions. Bromination of TMIU has also been shown to produce bromo derivatives.

CY5-SE triethylamine salt (Fluorolink Cy5 triethanolamine salt) is a hydrophilic amine-reactive fluorescent probe (Ex=649 nm; Em=670 nm).