Sucres du squelette et nucléobases

6-n-Propoxypurine (6-PP) is an intermediate in the purine biosynthetic pathway. It is a methylated adenosine analog that inhibits protein synthesis by inhibiting the enzyme ribonucleotide reductase and blocking the conversion of ribonucleotides to nucleotides. 6-PP also has autophagic activity, which may be due to its ability to decrease ATP levels. 6-PP is found in both cellular and extracellular environments, where it is converted into 6-dimethylaminopurine (6-DAP), a cytokinin with erythropoietic effects. 6-DAP can be methylated to produce 6-mercaptopurine riboside, a drug used for the treatment of some forms of cancer.

Applications N4-Aminocytidine (cas# 57294-74-3) is a useful research chemical.

Sulfo-Cyanine5, a Cy8 analog, works with typical fluorescence devices like imagers and microscopes.

Please enquire for more information about 3’-Azido-3’-deoxy-5-fluorouridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

6-Hydrazinopurine is an anti-hepatitis drug that is a prodrug for 6-chloropurine. Its mechanism of action is not fully understood, but it has been shown to bind to the virus receptor and inhibit the replication of the virus. It also competitively inhibits amines in biochemical assays. This property may be due to its hydroxyl group, which can form a hydrogen bond with the amino group of amines. It has been shown to be active against prostate carcinoma cells. 6-Hydrazinopurine has been shown to inhibit the growth of cancer cells by inducing apoptosis and decreasing cell proliferation.

8-Hydroxyguanine is a purine derivative that is found in DNA. It is a byproduct of oxidative damage to DNA and can cause mutations. 8-Hydroxyguanine binds to the α1 subunit of DNA polymerase, inhibiting the polymerization of nucleotides. This prevents the synthesis of new DNA, resulting in cell death. In humans, 8-hydroxyguanine appears to be repaired at a higher rate than other organisms such as bacteria. A study has shown that human cells are able to repair 8-hydroxyguanine by using an enzyme called O6-alkylguanine transferase (AGT). The AGT protein removes the alkyl group from the guanine base and replaces it with an amino group during repair. This process results in the formation of O6-methylguanine, which can be eliminated by methylation or excreted through urine.

Pyronin Y (Pyronine G) is an intercalating cationic dye that shows specificity towards RNA.

Applications 1,3-Diethyl-5-nitroso-6-aminouracil (cas# 89073-60-9) is a compound useful in organic synthesis.

6-Methylmercaptopurine is an important metabolite of 6-methylmercaptopurine, which is a vital component of the nucleotide synthesis pathway. It is used in analytical methods to determine levels of nucleotides, as well as in biological studies for its effect on autoimmune diseases. 6-Methylmercaptopurine can inhibit replication by inhibiting the methyltransferase enzyme.