Valproic Acid et Impuretés

Applications An impurity found in valproic acid (V094750, S674500). References Haj-Yehia, A., et al.: Pharm. Res., 6, 683 (1989), Davis, R., et al.: Drugs, 47, 332 (1994), Haj-Yehia, A., et al.: J. Pharm. Sci., 79, 719 (1990),

Applications A metabolite of Valproic Acid. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References McLean, M.J., et al.: J. Pharmacol. Exp. Ther., 237, 1001 (1986), Lee, R.D., et al.: J. Pharm. Sci., 78, 667 (1989), Mergen, F., et al.: J. Pharm. Pharmacol., 43, 815, (1991)

2-Demethoxy-2-chloro urapidil is an analytical standard that is used in drug development and research. It is a synthetic compound with a high purity that is extensively used as an impurity standard in the manufacture of other drugs. The CAS number for 2-demethoxy-2-chloro urapidil is 34661-73-9.

O-Desmethyl urapidil is an impurity of the drug product, urapidil. It is a synthetic compound that is not found in nature. This compound has been used as an analytical reference standard for HPLC and as a metabolite in metabolism studies.

Valproic Acid (2-Propylpentanoic Acid) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels.

Applications A metabolite of Valproic Acid. References McLean, M.J., et al.: J. Pharmacol. Exp. Ther., 237, 1001 (1986), Lee, R.D., et al.: J. Pharm. Sci., 78, 667 (1989), Mergen, F., et al.: J. Pharm. Pharmacol., 43, 815, (1991)