Alpha-bloquants

Stability Hygroscopic Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),

(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

2,2'-(1,4-Piperazinediyl)bis[6,7-dimethoxy-4-quinazolinamine] is a chemical compound that is used as a lead to develop new drugs against malaria. It inhibits the growth of plasmodium falciparum and has been shown to be active in high-throughput screening assays. 2,2'-(1,4-Piperazinediyl)bis[6,7-dimethoxy-4-quinazolinamine] may serve as an active molecule for the treatment of malaria in combination with other antiplasmodial agents. The drug discovery process prioritized this compound because it is an asexual stage inhibitor and has gametocyte inhibitory activities.

Compounds containing an unfused imidazole ring, whether or not hydrogenated, in the structure, nesoi

Aromatic or modified aromatic heterocyclic compounds withnitrogen hetero-atom(s) only nesoi

R-Terazosin is the active R-enantiomer and potent α1-adrenoceptor antagonist (Ki: α1a 6.51 nM, α1b 1.01 nM, α1d 1.97 nM).

Applications A metabolite of Mirtazapine (M365000). This compounds contains some of the alpha anomer. References Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Dahl, M., et al.: Clin. Drug Invest., 13, 37 (1997),

Trazodone (AF-1161), a 5-HT 2A/2C receptor antagonist, is used as an antidepressant for treating major anxiety disorders and depressive disorder.

Trazodone Hydrochloride BP Impurity A is an unproven impurity of Trazodone. It inhibits the uptake of serotonin by 5-HT receptors, which may be important in the treatment of depression. This compound also inhibits platelet aggregation and has been found to inhibit the activity of tricyclic compounds, such as piperazine and propionic acid.

Phenoxybenzamine hydrochloride: non-selective, irreversible alpha-blocker; antihypertensive, vasodilator, may cause tachycardia, potential carcinogen.