Modulateurs du GABA
Les modulateurs de GABA sont des composés qui influencent la fonction des récepteurs GABA (acide gamma-aminobutyrique), les principaux récepteurs inhibiteurs des neurotransmetteurs dans le système nerveux central. Ces modulateurs peuvent soit renforcer, soit inhiber l'activité GABAergique, affectant l'excitabilité neuronale et la transmission synaptique. Les modulateurs de GABA sont cruciaux dans le traitement et l'étude de divers troubles neurologiques et psychiatriques, y compris l'anxiété, l'épilepsie et l'insomnie. Chez CymitQuimica, nous proposons une large gamme de modulateurs de GABA pour soutenir vos recherches en neurosciences, pharmacologie et neurothérapeutique.
Produits appartenant à la catégorie "Modulateurs du GABA"
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4-Boc-7-Hydroxy-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS :Degré de pureté :97.0%Masse moléculaire :264.32501220703125Clobazam-13C6
CAS :Produit contrôléApplications Clobazam-13C6 is the isotope labelled analog of Clobazam (C582500); a benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic and anticonvulsant. Controlled substance (depressant). References Gastaut, H., et al.: Epilepsia, 20, 437 (1979); Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990); Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993)Formule :C6C10H13ClN2O2Couleur et forme :Off-WhiteMasse moléculaire :306.70Barbital
CAS :Produit contrôléApplications Prototype of the barbiturate hypnotics. References Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009), Yu, J., et al.: Pharm. Res., 27, 457 (2010), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010),Formule :C8H12N2O3Couleur et forme :NeatMasse moléculaire :184.194-Hydroxy Estazolam
CAS :Produit contrôléApplications A metabolite of Estazolam (E668380). Controlled Substance. References Gorski, J., et al.: Xenobiotica, 1999, 29, 931, Hesse, L., et al.: Drug Metab. Dispos., 29, 133 (2001),Formule :C16H11ClN4OCouleur et forme :White To Off WhiteMasse moléculaire :310.74Alprazolam 5-Oxide
CAS :Produit contrôléApplications A metabolite of Alprazolam (A575650). References Schwartz, M.A., et al.: J. Pharmacol. Exp. Ther., 149, 423 (1965), Childress, S.J., et al.: J. Pharm. Sci., 53, 577 (1964), Gall, M., et al.: J. Med. Chem., 21, 1290 (1978)Formule :C17H13ClN4OCouleur et forme :NeatMasse moléculaire :324.765-Ethyl-5-(1-ethylpropyl)-2-thiobarbituric Acid-d5
CAS :Produit contrôléFormule :C11D5H13N2O2SCouleur et forme :NeatMasse moléculaire :247.3697-Bromo-2,3,4,5-tetrahydro-1h-1,4-benzodiazepin-5-one
CAS :Degré de pureté :95+%Masse moléculaire :241.08799743652344Haloxazolam
CAS :Produit contrôléApplications Sleep-inducing agent, related structurally to Oxazolam and Cloxazolam (C587475). Sedative, hypnotic. Controlled substance (depressant). References Miyadera, T., et al.: J. Med. Chem., 14, 520, (1971), Yoshimoto, M., et al.: Chem. Pharm. Bull., 25, 1378 (1977),Formule :C17H14BrFN2O2Couleur et forme :NeatMasse moléculaire :377.21Prazepam-d5
CAS :Produit contrôléApplications Prazepam-d5, is the labeled analogue of Prazepam (P702250), a benzodiazepine derivative drug having anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. References Shader R. I., et al.: Ciba. Found. Symp., (74), 141 (1979); Jacqmin, P., et al.: Neuropsychobiology, 19 (4), 186 (1988);Formule :C192H5H12ClN2OCouleur et forme :NeatMasse moléculaire :329.83Desalkylflurazepam (7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one)
CAS :Formule :C15H10ClFN2OBromazepam (100μg/ml in Methanol)
CAS :Produit contrôléFormule :C14H10BrN3OCouleur et forme :ColourlessMasse moléculaire :316.15Thiobutabarbital-d5
CAS :Produit contrôléFormule :C10H11D5N2O2SCouleur et forme :NeatMasse moléculaire :233.34Nordazepam (1.0 mg/mL in Methanol)
CAS :Produit contrôléFormule :C15H11ClN2OCouleur et forme :Single SolutionMasse moléculaire :270.71N-Methoxymethyl Phenobarbital
CAS :Produit contrôléApplications A Phenobarbital derivative. Anticonvulsant. References Hansch, C., et al.: J. Pharm. Sci., 61, 1 (1972), Andrews, P., et al.: J. Med. Chem., 26, 1223Formule :C14H16N2O4Couleur et forme :NeatMasse moléculaire :276.288Clotiazepam-13C,d3
CAS :Produit contrôléApplications A labelled thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to benzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor.Controlled Substance. References Mandrioli, R. et al.: Curr.Drug Metab., 8, 827 (2008); Nakazawa, Y. et al.: Psychopharmacol., 44, 165 (1975); Yakushiji, T. et al.: Br. J. Pharmacol., 98, 735 (1989);Formule :C1513CH12D3ClN2OSCouleur et forme :NeatMasse moléculaire :322.837-Chloro-1-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS :Degré de pureté :98%Masse moléculaire :224.639999389648445-sec-Butylbarbituric Acid
CAS :Produit contrôléApplications 5-sec-Butylbarbituric Acid is an intermediate in the synthesis of Talbutal (T004975), a short to intermediate-acting barbiturate that act as nonselective depressants of the central nervous system (CNS). References Valwiler, E.H., et al.: J. Am. Chem. Soc., 47, 2236 (1925);Formule :C8H12N2O3Couleur et forme :NeatMasse moléculaire :184.19Desmethyl Cyclobenzaprine Hydrochloride
CAS :Impurity Cyclobenzaprine USP Related Compound B Applications Desmethyl Cyclobenzaprine (Cyclobenzaprine USP Related Compound B) is a metabolite of Cyclobenzaprine. References Wang, R.W., et al.: Drug Metab. Dispos., 24, 786 (1996),Formule :C19H19N·ClHCouleur et forme :Off-WhiteMasse moléculaire :297.827-methoxy-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
CAS :Degré de pureté :95%Masse moléculaire :220.2279968261728-Chloro-5,6-dihydro-5-methyl-6-oxo-4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Ethyl Ester
CAS :Produit contrôléImpurity Flumazenil EP Impurity F Applications 8-Chloro-5,6-dihydro-5-methyl-6-oxo-4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic Acid Ethyl Ester is an impurity of Flumazenil (F500450), an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. References Hunkeler, W., et al.: Nature, 290, 514 (1981), Pole, P., et al.: Arch. Pharmacol., 316, 317 (1981), Timm, U., et al.: Arzneim.-Forsch., 33, 358 (1983),Formule :C15H14ClN3O3Couleur et forme :NeatMasse moléculaire :319.74Nor-Flunitrazepam
CAS :Produit contrôléApplications A metabolite of Flunitrazepam (F500700). References Asai, H., et al.: J. Pharmacol. Exp. Ther., 277, 1004 (1996), Kilicarslan, T., et al.: Drug Metab. Dispos., 29, 460 (2001), Tanaka, E., et al.: J. Toxicol. Clin. Toxicol., 40, 69 (2002),Formule :C15H10FN3O3Couleur et forme :YellowMasse moléculaire :299.26Benzodiazepines mixture 8, 0.25mg/ml in Acetonitrile
Produit contrôléFormule :MixtureVisitourWebsiteMasse moléculaire :Mixture - Visit our WebsiteEthyl Loflazepate
CAS :Produit contrôléApplications A new benzodiazepine derivative as a new anti-anxiety drug. Ethyl Loflazepate and its metabolite were compared with those of Diazepam (D416855), Nitrazepam (N490140) and Lorazepam (L469850). The anticonflict effect of Ethyl Loflazepate was slightly more potent than that of Diazepam and much more potent than that of Lorazepam. Controlled substance. References Cano J.P., et al.: J. Chromatogr., 226, 413 (1981), Tanaka M., et al.: Clin. Neuropharmacology, (1985), 8, 271 (1985),Formule :C18H14ClFN2O3Couleur et forme :WhiteMasse moléculaire :360.774-Boc-7-Chloro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine
CAS :Degré de pureté :97.0%Masse moléculaire :282.7699890136719Phenylethylacetylurea (2-Phenylbutyrylurea)
CAS :Produit contrôléFormule :C11H14N2O2Couleur et forme :NeatMasse moléculaire :206.24Flurazepam-d10 Dihydrochloride
CAS :Produit contrôléApplications Labelled Flurazepam (F500800). Flurazepam is used as an sedative, hypnotic. This is a controlled substance (depressant). References Sternbach, L.H., et al.: J. Med. Chem., 8, 815 (1965), Schwartz, et al.: J. Med. Chem., 11, 770, (1968), Armagnac, et al.: Therapie, 26, 439 (1971), Ganjali, M., et al.: Curr. Pharm. Anal., 5, 28 (2009),Formule :C21H15D10Cl3FN3OCouleur et forme :NeatMasse moléculaire :470.86Midazolam 2-Oxide
CAS :Produit contrôléApplications A metabolite of Midazolam (M343000).Formule :C18H13ClFN3OCouleur et forme :NeatMasse moléculaire :341.77Flubromazolam
CAS :Produit contrôléApplications Flubromazolam is an analog of flubromazepam (F418600). Flubromazepam is a designer benzodiazepine drug structurally related to Phenazepam (P295300); a drug used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. Phenazepam (P295300) can also be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety. References Moosmann, B., et al.: J. Mass Spectrom., 48, 1150 (2013); Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989); Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993); Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008)Formule :C17H12BrFN4Couleur et forme :NeatMasse moléculaire :371.216,10-Dihydroxy Buspirone
CAS :Produit contrôléApplications 6,10-Dihydroxy Buspirone is an Impurity formed during the preparation of Buspirone metabolites. Also, it is derived from Buspirone (B689855), which is a non-benzodiazepine anxiolytic; 5-hydroxytryptamine (5-HT1) receptor agonist. References Wu, Y.H., et al.: J. Med. Chem., 15, 477 (1972); Allen, L.E., et al.: Arzneim.-Forsch., 24, 917 (1974); Goa, K.L., et al.: Drugs, 32, 114 (1986);Formule :C21H31N5O4Couleur et forme :NeatMasse moléculaire :417.5Heptobarbital
CAS :Produit contrôléImpurity Phenobarbital EP Impurity C Applications Phenobarbital (P316760) impurity. References Muster, T., et al.: J. Pharm. Sci., 91, 1432 (2002), Hardy, I., et al.: J. Pharm. Pharmacol., 55, 3 (2003),Formule :C11H10N2O3Couleur et forme :NeatMasse moléculaire :218.21Idobutal
CAS :Produit contrôléApplications Idobutal is used in the biotransformation of drugs, quantitative structure-activity relations, substance for the determination of barbiturates in the urine by using enzyme immunoassay and radio immunoassay, estimation of the solubility of drug like-organic compounds-case study in barbiturates. References Tong, G. L., et al.: J. Pharm. Sci., 65, 1651 (1976); Law, B., et al.: J. Forensic Sci. Soc., 21, 55 (1981); Louis, B., et al.: Chem. Biol. Drug Des., 74, 190 (2009)Formule :C11H16N2O3Couleur et forme :NeatMasse moléculaire :224.26Triazolam
CAS :Produit contrôléApplications Sedative, hypnotic.Controlled substance (depressant). References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981)Formule :C17H12Cl2N4Couleur et forme :WhiteMasse moléculaire :343.21Aprobarbital
CAS :Produit contrôléApplications Controlled substance (depressant). Sedative, hypnotic. References Frey, H.H., et al.: Arzneim. Forsch., 12, 389 (1962), Turner, J., et al.: Pharm. Res., 21, 68 (2004), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006),Formule :C10H14N2O3Couleur et forme :NeatMasse moléculaire :210.23Clozapine N-oxide, 99%
CAS :This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formule :C18H19ClN4ODegré de pureté :99%Masse moléculaire :342.839-CHLORO-3,4-DIHYDRO-1H-BENZO[E][1,4]DIAZEPINE-2,5-DIONE
CAS :Degré de pureté :97.0%Masse moléculaire :210.6199951171875Loprazolam-d8
CAS :Produit contrôléStability Light Sensitive Applications Labelled Loprazolam (L469510). Sedative, hypnotic. Controlled substance (depressant). References Agar, J.R., et al.: J. Med. Chem., 20, 1035 (1977), Clark, B.G., et al.: Drugs, 31, 500 (1986),Formule :C23H13D8ClN6O3Couleur et forme :NeatMasse moléculaire :472.95
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