Hormones dans les Protéines Recombinantes

Applications Methylstenbolone is an anabolic androgenic steroid that have been studied in respect of testosterone-receptor interaction and in the development of QSAR models. References Singh, D., et al.: J. Chem. Pharma. Rsch., 3, 1 (2011); McFarland, K., et al.: Science, 245, 494 (1989); Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998); Themmen, A., et al.: Endocr. Rev. 21, 551 (2000); Kumar, R., et al.: Biol. Reprod., 65, 710 (2001)

Applications It has been used in combinations as an oral contraceptive. References Brennan, D.M., et al.: Acta Endocrinol., 44, 367 (1963), Honma., s., et al.: Chem Pharm. Bull., 25 2019 (1977), Usui, T., et al.: Acta Urol. Jpn., 27, 327 (1981),

Stability Hygroscopic Applications A degradation product of Betamethasone (B327000). References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),

Applications It is used as cholesterol-lowering agent. References Bauer, D., et al.: Polym Deg. Stab., 48, 259 (1995), Nakahara, K., et al.: Chem. Physics Lett., 359, 351 (2002),

Applications A hydroxylated analogue of Tamoxifen (T006000) with anti-estrogenic properties. A Tamoxifen derivatives for imaging and treatment of estrogen receptor-positive tumors. References Ruenitz, P.C. et al.: J. Med. Chem., 25, 1056 (1982), Jalonen, H.G., et al.: J. Pharma. Sci., 77, 810 (1988), Yang, D.J., et al.: Pharma. Res., 8, 174 (1991),

Applications Isotope labelled Ethynyl Estradiol (E685100), an oral contraceptive (1), is a synthetic steroid with high oral estrogenic potency. Used in estrogen replacement therapy (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. References 1. Koetsawang, S. et al.: Contraception. 1982 March:25(3) p231-2412. Cuttler, L. et al.: J. Endocrinol. Metab. 1985 Jun;60(6):1087-92.

Impurity Rocuronium EP Impurity E Stability Hygroscopic Applications 2-Pyrrolidinyl desmorpholinylrocuronium Bromide (Rocuronium EP Impurity E) is an impuritiy of Rocuronium bromide (R639500), an aminosteroid and a competitive neuromuscular blocker. References Srinivasan, N., et al.: Oriental. J. Chem., 24, 989 (2008); Magorian, T., et al.: Anesthesiology, 79, 913 (1993); Wicks, T.C., et al.: J. Am. Assoc. Nurse Anesth., 62, 33 (1994)

Applications Cholesteryl Decanoate-d3 is the labeled analogue of Cholesteryl Decanoate (C432535), a lubricant additive used to improve the performance of lubricants. References Pavlov, A.S., et. al.: Zavodskaya Laboratoriya, Diagnostika Materialov, 77, 55 (2011)

Applications A systematic corticosteroid. Anti-inflammatory. References Mroszczak, E.J. et al.: J. Pharmac. Sci., 67, 920 (1978); Moellmann, H. et al.: Int. J. Clin. Pharmacol. Therap., 34, 1 (1996);

Applications A metabolite of Etiocholanolone. References Eriksson, H., et al.: Eur. J. Biochem., 15, 132 (1970), Cook, D., et al.: Endocrinology, 93, 1019 (1973),

GH2 Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues._x000D_ GH2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.01 kDa and the accession number is P01242.

Applications Triamcinolone Acetonide-d6 is the labeled analogue of Triamcinolone Acetonide (T767165), a glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal). References Florey, K., et al.: Anal. Profiles Drug Subs., 1, 397 (1972); Bernstein, I.L., et al.: Chest, 81, 20 (1982)

Applications An impurity of Dexamethasone (D298800), Desoxymethasone, Fluocortolone (F500500) and Diflucortolone. References Dekker, D., et al.: 5, 195 (1980),

Choriogonadotropin subunit beta is also known as CG-beta, Chorionic gonadotrophin chain beta.

Applications A labelled cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. References Brindle, J., et al.: Nat. Med., 12, 1439 (2002), Lindon, J., et al.: Biomarkers, 9, 1 (2004), Holmes, E., et al.: Cell, 134, 714 (2008),

Stability Hygroscopic Applications The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt. References Ho, R., et al.: J. Biol. Chem., 279, 7213 (2004), Pasanen, M., et al.: Eur. J. Clin. Pharmacol., 62, 409 (2006), He, Y., et al.: Drug Metab. Dispos., 36, 1453 (2008),

Applications A metabolite of Desoxymetasone (D296970). References Schriks, M., et al.: Environ. Sci. Technol., 44, 4766 (2010), Baeck, M., et al.: Eur. J. Dermatol., 20, 102 (2010), Lee, P., et al.: Bioorg. Med. Chem. Lett., 20, 69 (2010),

Stability Moisture Sensitive Applications Dexamethasone 21-Mesylate is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent. References Kim, T.H., et al.: J. Nanosci. Nanotech., 13, 7325 (2013); Joshi, T., et al.: Brit. J. Pharmacol., 172, 1360 (2015);

Impurity Fluocinolone Acetonide EP Impurity D Stability Hygroscopic Applications Fluocinolone acetonide-21-aldehyde, is a derivative of Fluocinolone Acetonide (F455800), which is a Corticosteroid, used in dermatology to reduce skin inflammation and relieve itching. References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),

Applications Androstenedione (A637550) analog, an aromatase inhibitor. References Marsh, D.A., et al.: J. Med. Chem., 28, 788 (1985),

Applications A labelled metabolite of Cortisol. References Dossing, M., et al.: Eur. J. Clin. Pharmacol., 25, 215 ( 1983), Gorski, J., et al.: Biochem. Pharmacol., 47, 1643 (1994), Raucy, J., et al.: Drug Metab. Dispos., 31, 533 (2003), Pal, D., et al.: Life Sci., 78, 2131 (2006),

Applications Pregnenolone-d6 is the labeled analogue of Pregnenolone (P712200), a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A. References Bjondahl, K., et al.: Med. Biol., 54, 454 (1976); Geick, A., et al.: J. Biol. Chem., 276, 14581 (2001); Johnson, D., et al.: Toxicol. Sci., 66, 16 (2002); Abe, C., et al.: Lipids, 42, 637 (2007)

Impurity Fluticasone EP Impurity G Applications Fluticasone Dimer Impurity (Fluticasone EP Impurity G) is a dimeric impurity of Fluticasone Propionate (F599500). References Mistry, N. et al.: J. Pharmac. Biomed. Anal., 19, 511 (1999);

Chorionic Gonadotropin/CGA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag.

Applications Labelled Cortisol (H714615). Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism. References Hechter, O., et al.: Arch. Biochem. Biophys., 25, 457 (1950), Colingsworth, D.R., et al.: J. Biol. Chem., 203, 807 (1953), Florey, K., et al.: Anal. Profiles Drug Subs., 12, 277 (1983),

Applications 17β-neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma. It can also work as an inhibitor of hERG channel trafficking. References Zhao, Q., et al.:Fitoterapia, 82, 735 (2011); Wang, L., et al.: J. Pharmacol. Exper. Ther., 320, 525 (2007)

Applications 5β-Dihydro Progesterone-d8 is labelled which is labelled 5β-Dihydro Progesterone (D449280), a metabolite of the neuroactive steroid Progesterone (PROG) (P755900). References Wiebe, J., et al.: Cancer Res., 60, 936 (2000), Lacasa, D., et al.: J. Biol. Chem., 276, 11512 (2001), Johansson, I., et al.: Brain Res., 934, 125 (2002), Leonhardt, S., et al.: Steroids, 68, 761 (2003),

Applications Labelled Chenodiol (Chenodeoxycholic acid). A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol. References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),