Nucléosides et Nucléotides
Les nucléosides sont des composés formés par une base azotée liée à un sucre (ribose ou désoxyribose). Lorsqu’un groupe phosphate est ajouté au nucléoside, un nucléotide est formé. Ces composés sont essentiels en biologie cellulaire, car les nucléotides sont les blocs fondamentaux de l’ADN et de l’ARN, responsables du stockage et de la transmission de l’information génétique. Les nucléosides ont des applications dans le traitement des maladies virales, en tant qu’inhibiteurs de la réplication virale. Les nucléotides, en plus de leur rôle structurel dans les acides nucléiques, interviennent dans les processus énergétiques, comme la synthèse de l’ATP.
Chez CymitQuimica, nous proposons une large gamme de nucléosides et de nucléotides essentiels à la recherche en biologie moléculaire, virologie et pharmacologie.
Produits appartenant à la catégorie "Nucléosides et Nucléotides"
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Gemcitabine hydrochloride
CAS :Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis.Formule :C9H11F2N3O4·HClDegré de pureté :99.28% - 99.98%Couleur et forme :White Crystalline Granular OdorlessMasse moléculaire :299.66Remdesivir impurity 6
CAS :Remdesivir impurity 6 is an impurity standard for a research and development drug product. It is a synthetic compound that has been custom synthesized for use in pharmacopoeia drug products. The purity of this compound is high and it has been shown to have no toxic effects on metabolism studies. Remdesivir impurity 6 is a metabolite of remdesivir, which is used as an antiviral agent for the treatment of HIV infection.Formule :C15H24NO5PDegré de pureté :Min. 95%Masse moléculaire :329.33 g/molAdenosine-15N
CAS :Produit contrôléApplications Nitrogen 15 labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes. References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)Formule :C10H13NN4O4Couleur et forme :NeatMasse moléculaire :268.235Molnupiravir Impurity 3 (Mixture of Diastereomers)
CAS :Formule :C9H16O6Couleur et forme :White To Off-White SolidMasse moléculaire :220.22Ganciclovir EP Impurity I (Ganciclovir Dipropionate)
CAS :Formule :C15H21N5O6Couleur et forme :White To Off-White SolidMasse moléculaire :367.36Penciclovir Impurity 5
CAS :Formule :C10H14N4O4Couleur et forme :Off-White SolidMasse moléculaire :254.254-Dehydroxy-4-dimethylhydroxysilyl entecavir
CAS :4-Dehydroxy-4-dimethylhydroxysilyl entecavir is an impurity standard for the drug product Entecavir. It is a synthetic drug that inhibits the production of human immunodeficiency virus (HIV) by binding to reverse transcriptase and blocking its activity. The metabolite of 4-dehydroxy-4-dimethylhydroxysilyl entecavir, entecavir, is also used as a treatment for HIV. Synthetic 4-dehydroxy-4-dimethylhydroxysilyl entecavir is used in clinical trials as a drug product and metabolite of entecavir to measure the concentration of the active ingredient in plasma and other body fluids. 4DDSILENT has been shown to have antiviral properties against HIV due to its ability to inhibit transcriptional activation by binding to reverse transcriptase, which prevents RNA from being synthesized into DNA.Formule :C14H21N5O3SiDegré de pureté :Min. 95%Masse moléculaire :335.43 g/molAdefovir Dipivoxil Impurity 2
CAS :Formule :C19H30N5O7PCouleur et forme :Off-White SolidMasse moléculaire :471.45Melphalan EP Impurity A (Dihydroxy Melphalan)
CAS :Formule :C13H20N2O4Couleur et forme :White To Off-White SolidMasse moléculaire :268.314-Amino-1-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl]-1,3,5-triazin-2(1H)-one
CAS :4-Amino-1-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl]-1,3,5-triazin-2(1H)-one (4AAT) is an analytical chemical that is used for research and development purposes. 4AAT is a metabolite of the antibiotic ampicillin and has been identified as an impurity in the drug product. It can be synthesized from 2-(4'-chlorophenyl)benzaldehyde, 3,5'-di-O-(4'-chlorobenzoyl)-2',3'-dideoxyribose and sodium azide in a two step process with 98% purity. 4AATs are also found to be present in natural products such as honey or sugar cane juice.Formule :C22H18Cl2N4O6Degré de pureté :Min. 95%Couleur et forme :White Off-White PowderMasse moléculaire :505.31 g/mol5-Methylcytidine
CAS :Produit contrôléStability Hygroscopic Applications 5-Methylcytidine is a derivative of Cytidine (C998300), found in ribonucleic acids of animals, plants and bacteria. 5-Methylcytidine is a nucleoside found in liver emulsion that can inhibit the growth of spontaneous tumors of mammary gland origin in mice. 5-Methylcytidine is one of many nucleosides that can be used as biomedical marker using liquid chromatography and ion trap mass spectrometry coupling. References Kammerer, B., et al.: Anal. Biol. Chem., 382, 1017 (2005); Strong, L. and Matsunaga, H.: J. Surg. Oncol., 4, 528 (1972)Formule :C10H15N3O5Couleur et forme :NeatMasse moléculaire :257.24Dapagliflozin Impurity 16
CAS :Formule :C22H27ClO7Couleur et forme :White To Off-White SolidMasse moléculaire :438.90Ganciclovir Bisvaline Ester DiHCl
CAS :Formule :C19H31N7O6·2HClCouleur et forme :White To Off-White SolidMasse moléculaire :453.50 2*36.462',3'-Isopropylidene ribavirin
CAS :Intermediate in the synthesis of ribavirinFormule :C11H16N4O5Degré de pureté :Min. 95%Masse moléculaire :284.27 g/mol1H-1,2,4-Triazole-3-carboxylic Acid
CAS :Produit contrôléFormule :C3H3N3O2Couleur et forme :NeatMasse moléculaire :113.07Sofosbuvir Nucleoside Derivative-13C-d3 (Sofosbuvir Metabolite(GS-331007)-13C-d3)
CAS :Formule :C913CH10D3FN2O5Couleur et forme :White To Off-White SolidMasse moléculaire :264.23(2S,5R)-Emtricitabine Carboxylic Acid
Formule :C8H8FN3O4SCouleur et forme :White To Off-White SolidMasse moléculaire :261.23Cytarabine
CAS :Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM).Formule :C9H13N3O5Degré de pureté :99.83% - 99.93%Couleur et forme :Fine Off-White Crystalline PowderMasse moléculaire :243.22N6-(2-Phenylethyl)adenosine
CAS :N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine) is an adenosine derivative and an agonist of adenosine receptors with Ki values of 11.8 nM and 30.1 nM forFormule :C18H21N5O4Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :371.39Etravirine Impurity 7
CAS :Formule :C20H17BrN6O2Couleur et forme :White To Off-White SolidMasse moléculaire :453.30Uridine-5'-Triphosphate Trisodium Salt
CAS :Formule :C9H12N2O15P3·3NaCouleur et forme :White To Off-White SolidMasse moléculaire :481.12 3*22.99Cangrelor Sulfoxide Tetrasodium Salt
CAS :Formule :C17H21Cl2F3N5O13P3S2·4NaMasse moléculaire :788.32 4*22.99Decitabine Impurity 31 (α-Isomers)
Formule :C7H14N4O4Couleur et forme :White To Off-White SolidMasse moléculaire :218.21Azacitidine Impurity 52 Formate (Mixture of Diastereomers)
CAS :Formule :C13H20N4O8·CH2O2Masse moléculaire :360.32 46.03β-lactamase Protein, E. coli, Recombinant (His & SUMO)
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.Couleur et forme :Lyophilized PowderMasse moléculaire :52.5 kDa (predicted)Peramivir Impurity 10
Formule :C15H28N4O4Couleur et forme :White To Off-White SolidMasse moléculaire :328.41Emtricitabine L-Menthyl Ester ((2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic Acid (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl Ester)
CAS :Produit contrôléFormule :C18H26FN3O4SCouleur et forme :NeatMasse moléculaire :399.48Ubidecarenone (Coenzyme Q10) EP Impurity E (Ubicromenol)
Formule :C59H90O4Couleur et forme :Pale Brown OilMasse moléculaire :863.37Capecitabine Impurity 39
CAS :Formule :C20H30FN3O9Couleur et forme :Off-White SolidMasse moléculaire :475.48Canagliflozin Ring Opening Impurity
Formule :C24H27FO6SCouleur et forme :White To Off-White SolidMasse moléculaire :462.54Remdesivir impurity 11
CAS :CAS No. 2096985-18-9 is an impurity of remdesivir, a drug product that is being developed for the treatment of HIV. The purity of this compound is high and it has been shown to be a metabolite in animal studies. Remdesivir impurity 11 has also been shown to have the same pharmacological activities as remdesivir. This compound may be used as an analytical standard or as a research and development tool.Formule :C21H23N6O8PDegré de pureté :Min. 95%Masse moléculaire :518.42 g/molDecitabine Impurity 1 (α-Isomer)
CAS :Formule :C6H12O4Couleur et forme :Pale Yellow LiquidMasse moléculaire :148.16Lamivudine Triphosphate Triammonium Salt
CAS :Formule :C8H11N3O12P3SH4NMasse moléculaire :466.17 3*18.04CX516
CAS :CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and MCI.Formule :C14H15N3ODegré de pureté :99.29% - ≥95%Couleur et forme :Tan SolidMasse moléculaire :241.29Ribavirin Impurity 41
CAS :Formule :C7H7N5O2Couleur et forme :Off-White SolidMasse moléculaire :193.17Adenosine 5'-Diphosphate Sodium Salt
CAS :Produit contrôléStability Hygroscopic Applications Adenosine 5'-diphosphate monosodium salt (cas# 20398-34-9) is a useful research chemical.Formule :C10H15N5O10P2·x(Na)Couleur et forme :White To Off-WhiteMasse moléculaire :427.20 + x(22.99)1-(5-O-Benzoyl-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
CAS :Produit contrôléFormule :C17H16N2O5Couleur et forme :NeatMasse moléculaire :328.3193Acyclovir (Aciclovir) Impurity H
CAS :Formule :C17H17N5O5Couleur et forme :White To Off-White SolidMasse moléculaire :371.35Famciclovir N-Acetyl Impurity
Formule :C16H21N5O5Couleur et forme :White To Off-White SolidMasse moléculaire :363.37Peldesine
CAS :Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.Formule :C12H11N5ODegré de pureté :99.27% - 99.95%Couleur et forme :SolidMasse moléculaire :241.25Ref: TM-T12399
1mg114,00€5mg274,00€10mg439,00€25mg727,00€50mg1.017,00€100mg1.378,00€500mg2.737,00€1mL*10mM (DMSO)303,00€UDP-α-D-Galactose-13C6 Disodium Salt
CAS :Formule :C913C6H22N2O17P2·2NaMasse moléculaire :570.24 2*22.99Lamivudine
CAS :Formule :C8H11N3O3SCouleur et forme :White To Off-White SolidMasse moléculaire :229.252-Chloroadenine (2-Chloro-7H-purin-6-amine)
CAS :Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoiFormule :C5H4ClN5Couleur et forme :Off-White White Light Yellow PowderMasse moléculaire :169.01552Melphalan EP Impurity A (R-Isomer) DiHCl (Dihydroxy Melphalan (R-Isomer) DiHCl)
CAS :Formule :C13H22Cl2N2O4·2HClCouleur et forme :Off-White SolidMasse moléculaire :268.31 2*36.46Ganciclovir Related Compound A ((RS)-2-Amino-9-(2,3-dihydroxy-propoxymethyl)-1,9-dihydro-purin-6-one)
CAS :Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure, nesoiFormule :C9H13N5O4Couleur et forme :White Off-White PowderMasse moléculaire :255.09675Ganciclovir
CAS :Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structureFormule :C9H13N504Couleur et forme :White Off-White PowderMasse moléculaire :7178.65102Fructose
CAS :Chemically pure fructose in solid formFormule :C6H12O6Couleur et forme :White Colorless Crystalline PowderMasse moléculaire :180.06339Lamivudine acid
CAS :Lamivudine acid is a synthetic orotate prodrug that is converted to the active form, lamivudine. It inhibits the synthesis of viral DNA by inhibiting the reverse transcriptase enzyme and has been used as a treatment for HIV infection. Lamivudine acid is soluble in organic solvents such as acetone and cyclohexane. The crystal structure of this compound has been determined using X-ray crystallography and exhibits a zwitterion structure with a hydrogen bond between the carboxylate group and the amide nitrogen atom of the molecule.Formule :C8H9N3O4SDegré de pureté :Min. 95%Masse moléculaire :243.24 g/molGanciclovir Sodium Salt
CAS :Formule :C9H12N5O4·NaCouleur et forme :White To Off-White SolidMasse moléculaire :254.23 22.993,4,5,6-Tetrahydrouridine (>80%)
CAS :Stability Light Sensitive Applications 3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA. References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Funamizu, N., PLoS One, 37424 (2012);Formule :C9H16N2O6Degré de pureté :>80%Couleur et forme :NeatMasse moléculaire :248.23(+)-Carbovir triphosphate
CAS :(+)-Carbovir triphosphate, Abacavir's active metabolite, studied for HIV-1 resistance and inhibition mechanisms.Formule :C11H16N5O11P3Couleur et forme :SolidMasse moléculaire :487.19Acyclovir EP impurity R
CAS :Acyclovir EP impurity R is a by-product of acyclovir, which has been shown to be stable in acidic and alkaline conditions. It is also linear with high reproducibility and low detection limits. Acyclovir EP impurity R can be detected using a validated RP-HPLC method with an acidified mobile phase. The compound is not photolyzed under the conditions of the assay. This impurity has been detected in batches of acyclovir that have been produced on two different production lines for more than 5 years without any changes in quality or yield.Formule :C13H21CIN6O4Degré de pureté :Min. 95%Masse moléculaire :464.26 g/mol2-epi-Emtricitabine
CAS :Applications The 2-epi-enantiomer analogue of (-)-Emtricitabine (E525000) evaluated against HIV-1 in human peripheral blood mononuclear (PBM) cells. References Jeong, L.S., et al.: J. Med. Chem., 36, 2627 (1993),Formule :C8H10FN3O3SCouleur et forme :Off White SolidMasse moléculaire :247.25Cidofovir Diphosphate Trisodium Salt (>85%)
CAS :Produit contrôléApplications Cidofovir Diphosphate Trisodium Salt has antiviral activity, which is used against herpes viruses. Cidofovir Diphosphate is a metabolite in human cells. References Hitchcock, M. J. M., et al.: Antivir. Chem. Chemoth., 7, 115-127 (1996); Cihlar, T., et al.: Collect. Czech. Chem. C., 57, 661-72 (1992)Formule :C8H13N3Na3O12P3Degré de pureté :>85%Couleur et forme :NeatMasse moléculaire :505.092Molnupiravir Impurity 7
CAS :Formule :C13H18N2O7Couleur et forme :Whtie SolidMasse moléculaire :314.29Cladribine
CAS :Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormule :C10H12ClN5O3Couleur et forme :White Off-White PowderMasse moléculaire :285.06287β-(Z)-Brivudine
CAS :Formule :C11H13BrN2O5Couleur et forme :Pale Yellow SolidMasse moléculaire :333.14Fludarabine Phosphate EP Impurity B
CAS :Formule :C5H5N5OCouleur et forme :Off-White SolidMasse moléculaire :151.13LY2334737
CAS :LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.Formule :C17H25F2N3O5Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :389.39Ref: TM-T4061
1mg62,00€5mg131,00€10mg205,00€25mg378,00€50mg562,00€100mg777,00€200mg1.074,00€1mL*10mM (DMSO)166,00€Gemcitabine
CAS :Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis.Formule :C9H11F2N3O4Degré de pureté :100% - 99.67%Couleur et forme :SolidMasse moléculaire :263.2Ubidecarenone (Coenzyme Q10) EP Impurity C (Mixture of Isomers)
CAS :Formule :C49H74O4Masse moléculaire :727.13Adenosine 5'-Triphosphate as Disodium Salt
CAS :Formule :C10H14N5O13P3·2NaMasse moléculaire :505.17 2 22.99Favipiravir
CAS :Formule :C5H4FN3O2Couleur et forme :White To Off-White SolidMasse moléculaire :157.10NADPH tetracyclohexanamine
CAS :NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.Formule :C45H82N11O17P3Degré de pureté :98.73% - 99.05%Couleur et forme :SolidMasse moléculaire :1142.12Folinic acid calcium
CAS :Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.Formule :C20H21CaN7O7Degré de pureté :100% - 99.5%Couleur et forme :Yellow Crystalline PowderMasse moléculaire :511.51Canagliflozin Impurity 21
CAS :Formule :C18H14FISCouleur et forme :White To Off-White SolidMasse moléculaire :408.27Remdesivir impurity 2
Remdesivir impurity 2 is an analytical standard used in the development of drugs. It is a metabolite found in the drug Remdesivir. It is a natural product that can be synthesized or isolated from natural sources. Remdesivir impurity 2 is soluble in water and acetonitrile, and it has a melting point of 80-81 degrees Celsius. It has a molecular weight of 208.3 g/mol and CAS number 249712-00-1. This compound is not listed on the current edition of the USP Pharmacopoeia.Formule :C19H19N5O4Degré de pureté :Min. 95%Masse moléculaire :381.39 g/molRemdesivir impurity 10
CAS :Remdesivir impurity 10 is a synthetic chemical compound that has been synthesized for research and development. It is an impurity standard of remdesivir, which is not present in any drug product. The purity of this product is high, and it can be used as a pharmacopoeia or drug development standard. It can also be used as an analytical standard to measure the concentration of metabolites in animal studies or metabolism studies.Formule :C27H35N6O8PDegré de pureté :Min. 95%Masse moléculaire :602.58 g/molD-2’-Deoxyribofuranosyl-3-guanylurea(α/β-Mixture)
CAS :Produit contrôléStability Hygroscopic Applications Hydrolytic impurity of D226730 and A796950 (decitabine) References Beisler, Jj.A., et al.: J. Med. Chem., 21, 204 (1978),Formule :C7H14N4O4Couleur et forme :NeatMasse moléculaire :218.2105Adenosine 5'-monophosphate monohydrate
CAS :Produit contrôléFormule :C10H14N5O7P·H2OCouleur et forme :NeatMasse moléculaire :365.23Diquafosol Free Base
CAS :Diquafosol Free Base is a purinoceptor P2Y(2) receptor agonist.Formule :C18H26N4O23P4Couleur et forme :SolidMasse moléculaire :790.31Famciclovir
CAS :Famciclovir (BRL 42810) inhibits Herpes virus DNA polymerase by mimicking nucleosides.Formule :C14H19N5O4Degré de pureté :99.85%Couleur et forme :Off-White PowderMasse moléculaire :321.33Ganciclovir EP Impurity E (Ganciclovir USP Related Compound A, Iso-Ganciclovir)
CAS :Formule :C9H13N5O4Couleur et forme :White To Off-White SolidMasse moléculaire :255.238-Amino[1''-(N''-dansyl)-4''-aminobutyl]-5'-(1-aziridinyl)-5'-deoxy adenosine
CAS :Formule :C28H37N9O5SMasse moléculaire :611.73Folinic Acid Impurity 1 Trifluoroacetate
CAS :Formule :C19H23N7O6·C2HF3O2Masse moléculaire :445.44 114.02(2S,5S)-Emtricitabine Carboxylic Acid
Formule :C8H8FN3O4SCouleur et forme :Off-White SolidMasse moléculaire :261.23Laninamivir
CAS :Laninamivir (R 125489) inhibits influenza NA (IC50: 0.90-3.12 nM) across strains H12N5, pH1N1, and H2N2.Formule :C13H22N4O7Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :346.34Vitamin B6 Impurity 3
Formule :C12H17NO3Couleur et forme :White To Off-White SolidMasse moléculaire :223.27Etravirine EP Impurity D
CAS :Formule :C20H16N6OCouleur et forme :Pale Yellow SolidMasse moléculaire :356.39Remdesivir Impurity 21
CAS :Formule :C26H26O5Couleur et forme :White To Off-White SolidMasse moléculaire :418.49Emtricitabine Impurity 34
Formule :C30H39FN9O8PSCouleur et forme :Off-White SolidMasse moléculaire :735.73Clofarabine Impurity 6
CAS :Formule :C26H21FO7Couleur et forme :Off-White SolidMasse moléculaire :464.45Capecitabine EP Impurity B (5'-DFUR, Doxifluridine)
CAS :Formule :C9H11FN2O5Couleur et forme :White To Off-White SolidMasse moléculaire :246.19Methylcobalamin Impurity 6
CAS :Formule :C14H18N2O4Couleur et forme :White To Off-White SolidMasse moléculaire :278.31
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