Source botanique

(-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1,2)-β-D-glucopyranoside is a lignan glycoside, which is a type of secondary metabolite. This compound is primarily derived from plant sources, often isolated from the heartwood of various trees or other lignan-rich plant materials. The extraction typically involves advanced chromatographic techniques that separate and purify it from complex plant matrices. The mode of action of (-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1,2)-β-D-glucopyranoside largely centers around its antioxidant properties. It scavenges free radicals, thereby reducing oxidative stress and potentially modulating various biochemical pathways involved in cellular protection and repair processes. Its uses and applications are primarily in the field of scientific research. These include studies on oxidative stress, natural product pharmacology, and the exploration of novel antioxidants. Researchers may investigate its potential benefits in reducing oxidative damage in biological systems or as a lead compound for developing pharmacologically active agents. Additionally, it could serve as a model compound for elucidating the structure-activity relationships of lignan glycosides.

Isoliquiritigenin(ILTG), a flavonoid constituent in the root of Glycyrrhiza glabra, has vasorelaxant effect, anti-platelet, anti-allergic and antiviral activities, also has protective effects in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats.

Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. It induces human plasma cell apoptosis by provoking endoplasmic reticulum stress and induces cell death by activating the p38 but not the JNK signaling pathway.

L-Theanine is a relaxing and nondietary amino acid found pretty much exclusively in teas from Camellia sinensis. It is known to promote relaxation and improve concentration and learning ability and has neuroprotective effects. L-Theanine heals gastric ulcer and prevents CCl4-induced experimental hepatic cirrhosis in rats by blocking the main pro-inflammatory and pro-fibrogenic signals. L-Theanine can significantly alleviate the adverse oxidative effect.

Cosmosiin and rhoifolin from red wendun leaves may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.

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Amentoflavone, a biflavonoid with antiinflammatory activity, inhibits NF-κB/DNA binding activity potently along with inhibition of degradation of IκBα and NF-κB translocation into nucleus in TNFα-activated A549 cells.

Rebaudioside E is a high-intensity sweetener, which is a glycoside derived from the Stevia rebaudiana plant. This particular compound is among the numerous steviol glycosides present in stevia leaves, extracted through water or alcohol-based extraction and subsequent purification processes. Its mode of action involves binding to the sweet taste receptors on the tongue, similar to other intense sweeteners, yet it provides sweetness without caloric input. In terms of applications, Rebaudioside E is utilized predominantly in the food and beverage industry. Its high sweetness potency, around 150-300 times that of sucrose, and negligible caloric content make it an attractive alternative to sugar, especially in formulations aimed at reducing caloric value without compromising taste. It is employed in a variety of products, including soft drinks, confectioneries, and dairy products. Researchers continue to study its potential synergistic effects when combined with other sweeteners, aiming to optimize taste profiles while maintaining health benefits.

Isosakuranetin is a plant exudate with known cytotoxic and fungicide properties, it may act on wheat root segments as an inhibitor of K+ permeation. Isosakuranetin is a TRPM3 blocker, significantly reduces the sensitivity of mice to noxious heat and PregS-induced chemical pain; it induced- inhibition of ERK1/2 and PI3K/AKT signaling pathways activate MITF and subsequent expression of Tyr, TRP1, and TRP2.

Ligustroflavone shows high antioxidant capacity and is reported to be an AMPK activator, it activates AMPK by increasing ratio of AMP / ATP and promotes adiponectin multimerization by activating AMPK.

Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity.Decursinol angelate has protective effects against amyloid β-protein-induced oxidative stress in the PC12 cell line. It improves wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors. Decursinol angelate has in vitro and in vivo antifungal activity against Magnaporthe oryzae, the causal agent of rice blast.

Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellular stores. Saikogenin D has immunomodulatory effect, it can attenuate IL-6 production in LPS-stimulated alveolar macrophages of B6 more than in that of BALB.

5,6-O-Isopropylidene-phlorigidoside B is a specialized phytochemical compound, which is a derivative of natural glycosides. This compound is typically sourced from certain plant species known for producing bioactive secondary metabolites. The synthesis of this compound involves the acetalization of hydroxyl groups, creating an isopropylidene protective group, which can influence its stability and solubility properties. The mode of action of 5,6-O-Isopropylidene-phlorigidoside B generally involves interaction with specific biological pathways, possibly modulating enzyme activity or receptor binding. Such interactions can lead to diverse effects, including antioxidant, anti-inflammatory, or other bioactive responses depending on the application. This compound’s potential uses extend to various fields such as pharmaceuticals, where it may serve as a lead compound for drug development. Additionally, it can be employed in biochemical research to study plant-derived bioactive effects, or in agriculture to explore natural plant defense mechanisms. The exploration of its properties and interactions can provide valuable insights into its potential therapeutic or industrial applications.

Obacunone is a novel activator of Nrf2, which exhibits anti-cancer, anti-inflammatory, antivirulence, insecticidal, anti-proliferative and anti-aromatase activities. Obacunone stimulates muscle hypertrophy and prevents obesity and hyperglycemia, and that these beneficial effects are likely to be mediated through the activation of TGR5 and inhibition of PPARγ transcriptional activity. Obacunone significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM, and it also inhibits the p38 MAPK signaling pathway.