Étalons relatives aux hydrocarbures aromatiques polycycliques (HAP)

Applications 1-Hydroxypyrene-d9 is found in humane urine after exposure to coal tar and a coal derived product. References Jongeneelen, F.J., et al.: Int. Arch. Occup. Environ. Health, 57, 47 (1985)

Applications 5,​6-​Chrysenedione is a useful reactant for organic reactions. It is a polycyclic aromatic hydrocarbon quinones, and studied as possible carcinogens. References Boyle, K.M., et al.: J. Am. Chem. Soc., 140, 5612-24 (2018); Shultz, C.A., et al.: Chem. Res. Toxicol., 24, 2153-66 (2011);

Applications Polycyclic aromatic hydrocarbons (PAHs) and their PAH-DNA adducts in lung tissues, and their ability to mutate the Ki-ras oncogene in PAH-induced tumors. Seven PAHs were studied: cyclopenta[cd]pyrene (CPP), benzo[a]pyrene (B[a]P), benzo[b]fluoranthene (B[b]F), dibenz[a,h]anthracene (DBA), 5-methylchrysene (5MC), benz[j]aceanthrylene (B[j]A), and dibenzo[a,l]pyrene (DB[a,l]P). References Nesnow, S., et al.: Cancer Lett., 73, 73 (1993), Herzog, C., et al.: Cancer Res., 54, 4007 (1994), Prahalad, A., et al.: Carcinogenesis, 18, 1955 (1997),

Applications 1-Methoxynaphthalene is one of the numerous volatile components found in tobacco smoke, and has been found to induce damage on plasma membrane tissues of cultured human lung fibroblasts. References Thelestam, M., et al.: Toxiology, 15, 203 (1980)

Applications 1-(2-(Phenanthren-9-yl)phenyl)propan-2-one is an metabolite of Dibenzo[def,p]chrysene (D416945), an well known polycyclic aromatics hydrocarbons found in hot mix asphalt paving workers and the most potent tumorigen that has been identified to date.

Stability Moisture Sensitive Applications Phorate Oxon Sulfone is a major metabolite of Phorate (P353500), an inhibitor of acetylcholinesterase and pseudocholinesterase. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Boshoff, P.R., et al.: J. Agr. Food Chem., 27, 626 (1979),

Applications 5-Nitroacenaphthene is a derivative of acenaphthene, a polycyclic hydrocarbon that has potential to act as polyploidizing agents in plants. References Liu, Y., et al.: J. Med. Chem., 57, 5203 (2014);

Applications Labelled Dibenzo[a,l]pyrene (D416945). An active metabolite from inhalation and dermal exposure to polycyclic aromatics hydrocarbons in hot mix asphalt paving workers. DBC is the most potent tumorigen that has been identified to date. Dibenzo[def,p]chrysene (DBC) is a carcinogen and should be handled with appropriate caution. References Anderson, L., et al.: Toxicol. Appl. Pharmacol., 199, 85 (2004), Yu, Z., et al.: Cancer Res., 66, 755 (2006), Shen, J., et al.: Toxicol. Sci., 95, 313 (2007),

Applications 3-Nitroacenaphthene is an impurity of Acenaphthene (D448330), which is a polycyclic aromatic hydrocarbon as carcinogenic agent. References Liu, Y., et al.: J. Med. Chem., 57, 5203 (2014);

Applications Naphtho[2,3-e]pyrene is a polycyclic aomatic hydrocarbon (PAH) with carcinogenicity. Naphtho[2,3-e]pyrene is one of the C24H14 PAH that displayed mutagenicity in human cells expressing CYP1A1. References Yan, L.S.: Carcinogenesis6, 1 (1985); Durant, J.L. et al.: Mutat. Res. Gen. Toxicol. Environ. Mutagen., 446, 1 (1999);