APIs pour la recherche et les impuretés

(2S,4S)-tert-Butyl 2-(5-(2-((2S,5S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidin-2-yl)-1,11-dihydroisochro meno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate is a drug product that has been synthesized and is being developed for the treatment of cancer. (2S,4S)-tert-Butyl 2-(5-(2-[(2R,5R)-1-[(R) -2-[(methoxycarbonyl)amino]-

Applications Serotonin is a monoamine neurotransmitter. References Kuraishi, Y., et al.: Biol. Pharm. Bull., 31, 2143 (2008); Morera, E., et al.: Bioorg. Med. Chem. Lett., 19, 6806 (2009); Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010);

Stability Moisture Sensitive Applications Sinapic Acid Acyl-β-D-glucoside is a metabolite of Sinapic Acid (S486800). References Shirley, A., et al.: J. Biol. Chem., 278, 19870 (2003), Abdulrazzak, N., et al.: Plant Physiol., 140, 30 (2006), Besseau, S., et al.: Plant Cell, 19, 148 (2007), Fiehn, O., et al.: Plant J., 53, 691 (2008),

Applications Anticholinergic. Antispasmodic. References Lundstam, S., et al.: Lancet, 1, 1096 (1982), Thompson, J., et al.: Br. Med. J., 299, 1140 (1989), Marthak, K., et al.: Curr. Med. Res. Opi., 12, 366 (1991), Panderi, I., et al.: J. Pharm. Biomed. Anal., 12, 151 (1994),

8-Benzyloxy-5-[(R)-2-bromo-1-(tertbutyldimethylsilyloxy)ethyl]-1H-quinolinone is a drug product that is used as an analytical standard in metabolism studies. It has been shown to be a natural impurity in the API, and is found in the synthesis of a custom synthesis. 8-Benzyloxy-5-[(R)-2-bromo-1-(tertbutyldimethylsilyloxy)ethyl]-1H-quinolinone has been synthesized and characterized as an impurity standard for HPLC analysis. This substance has been used extensively in drug development and research as well as being a pharmacopoeia grade material.