APIs pour la recherche et les impuretés

Lipid chain (stearic bi-acid) plus γ-glutamic acid or glutamate (γ-Glu) amino acid.

Agomelatine dimer acetamide is an impurity of agomelatine, an antidepressant that is used in the treatment of major depressive disorder. Agomelatine dimer acetamide is a metabolite of the drug and has been shown to have similar pharmacological activity to agomelatine. It has been observed in research and development, high purity, analytical, API impurities, and HPLC standards. Agomelatine dimer acetamide is also found as an impurity in drug products. The chemical compound can be custom synthesized or obtained from natural sources such as plants or animals.

Applications Labelled Clomiphene. Synthetic estrogen agonist-antagonist. Gonad-stimulating principle. References Palopoli, F.P., J. Med. Chem., 10, 84 (1967), Ernst., et al.: J. Pharm. Sci., 65, 148 (1976), Baustian, C.L., et al.: Pharm. Biomed. Anal., 4, 237 (1986),

1,3-Bis(9H-carbazol-4-yloxy)-2-propanol is a metabolite of carvedilol. It is not active as a drug, but may have pharmacological effects. 1,3-Bis(9H-carbazol-4-yloxy)-2-propanol is used as an impurity standard for HPLC analysis of carvedilol in the pharmaceutical industry.

The impurity (2,6-dichlorobenzaldehyde) is a metabolite of montelukast. It is an analytical impurity that has been quantified in the drug product and has also been found to be present in the synthetic process. The impurity standard was developed using HPLC. It can be used as a high purity reference material for pharmacopoeia and custom synthesis.

Stability Hygroscopic Applications Tris(2-ethylhexyl) Phosphate-d51 is labelled Tris(2-ethylhexyl) Phosphate (T884650) which is used as a phosphorous flame retardant. Tris(2-ethylhexyl) Phosphate (T884650) is also used as a plasticizer in the preparation of a new potentiometric membrane sensor. References Ballesteros-Gomez, A. et al.: Anal. Chem., 85, 9572 {2013); Gholivand, M. et al.: Adv. Sci. Eng. Med., 5, 73 (2013);

Stability Hygroscopic Applications Sodium salt of Cephalothin (C261150), a first generation cephalosporin antibiotic with a wide range antibacterial activity. It is effective against gram-positive and gram-negative bacteria, and has been tested in respiratory disease and neuromuscular junction studies. References Shibata, K., et al.: J. Antibiot., 50, 135 (1997); Farra, A., et al.: Int. J. Antimicrob. Agents., 31, 427 (2008); Pichardo, C., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 30, 289 (2011);