APIs pour la recherche et les impuretés

1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol) ammonium salt (DOPMP) is a synthetic compound that is used as an impurity standard for the manufacture of drug products. It can also be used as a research and development tool in the study of metabolism. DOPMP is not found in nature and has a CAS number of 799268-53-4. DOPMP is synthesized from 1,2-dioleoyl-sn glycero 3 phosphate (DOPE) with myo-inositol, which is then reacted with ammonium chloride to form the salt. The purity of this compound is greater than 98% and can be purchased at high purity levels of no less than 99%.

Applications A CNS stimulant. Anorexic. In attention deficit disorder with hyperactivity. Controlled substance (stimulant). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lands, M., et al.: J. Pharmacol. Exp. Ther., 89, 382 (1947), Repke, D.B., et al.: J. Pharm. Sci., 67, 1167 (1978), Pope, H.G., et al.: J. Clin. Psychiatry, 47, 339 (1986), Cho, A.K., et al.: Science, 249, 631 (1990),

Perindopril-N-desethylpentanoate is a drug product that is used in research and development of new drugs. It belongs to the class of drugs called angiotensin converting enzyme inhibitors, which act by inhibiting the conversion of angiotensin I to angiotensin II. Perindopril-N-desethylpentanoate can be used for the manufacture of HPLC standards. It can also be used as an analytical standard for impurities found in API, and has been shown to have niche applications in metabolism studies. This compound is purified to high purity levels that meet pharmacopoeia requirements.

Applications This compound binds to inactivated acetylcholinesterases and is used to combat poisoning from organophosphates and nerve agents References Lajmanovich, R., et al.: Toxicol. Env. Chem., 90, 1145 (2008), Eyer, P., et al.: Brit. J. Clin. Pharmacol., 66, 450 (2008), Goncalves, L., et al.: J. Pharm. Sci., 98, 1040 (2009),

Applications L-Isoleucine-d10 is an isotope labelled analog of L-Isoleucine, which is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats. References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)

Clindamycin is a semisynthetic antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Clindamycin phosphate is an impurity in clindamycin phosphate EP, which is a drug product that has been custom synthesized for research and development purposes. The impurity standard for this product is CAS No. 997-06-4 and Impurity Standard: 99.0%. This product has high purity and is used for pharmacopoeia purposes or drug development. Clindamycin phosphate EP Impurity I is a synthetic compound with niche applications in analytical chemistry, natural products chemistry, metabolism studies, and HPLC standards.

Applications A major oxidative labelled metabolite of Pentoxifylline. A potent inhibitor of phosphatidic acid generation (IC50=0.6uM). Protects mice from endotoxic shock and attenuates sepsis-induced acute lung injury in pig. References Clarke, E., et al.: Cancer Res., et al.: 56, 105 (1996), Itani, S., et al.: Metabolism, 50, 553 (2001), Itani, S., et al.: Diabetes, 51, 2005(2002), Yu, C., et al.: J. Biol. Chem., 277, 50230 (2002),