APIs pour la recherche et les impuretés

Applications Semi-synthetic cephalosporin antibiotic. References Muggleton, et al.: Antimicrob. Agents Chemother., 253 (1968), Marrelli, L.P., et al.: Anal. Profiles Drug Subs., 4, 21 (1975),

Applications Phenylbutazone(diphenyl-d10) is the isotope labelled analog of Phenylbutazone (P319570); a non-steroidal anti-inflammatory compound and an inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ali, S.L., Anal. Profiles Drug Subs., 11, 483 (1982); Hughes, M.F., et al.: Mol. Pharmacol., 34, 186 (1988)

Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),

Roflumilast Impurity B is an oxidative reagent that can be used for the preparation of a variety of organic compounds. It is a white solid that is soluble in organic solvents. Roflumilast Impurity B has been shown to be hepatotoxic, and should only be handled with gloves and lab coat. This material should not come in contact with skin or eyes. In addition, this reagent should not be exposed to light as it may cause photolysis.

9-(1,3-Dioxolan-2-ylmethyl)-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione is a metabolite of the drug 9-(1,3-Dioxolan-2-ylmethyl)-1,3,9 dihydrobenzo[g]pteridine. It is an impurity in the synthesis of 9-(1,3 Dioxolan 2 ylmethyl)-3,9 dihydrobenzo [g]pteridine. The purity of this compound is > 99%, with a melting point range of 233 to 235 °C and a molecular weight of 244.24 g/mol. It is soluble in methanol and acetonitrile. This compound has been characterized by IR spectroscopy (ATR), 1H NMR (400 MHz) spectroscopy (CDCl 3 ), and mass spectrometry (HRMS