Peptides

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Lactacystin is a peptide that acts as an activator of ion channels. It binds to the receptor and activates the ligand-gated ion channel, which then opens the ion channel. This leads to increased influx of ions into the cell and an increase in intracellular calcium concentration. Lactacystin has been used as a research tool for studies on protein interactions, such as antibody-antigen interactions and receptor-ligand interactions. Lactacystin is also used for pharmacological purposes, such as for pain relief or for treatment of epilepsy.

The Histone H3 (22-30)-K27Me3 is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter to change the positioning of the nucleosome, allowing the DNA it to be either available to the transcription machinery or inaccessible.The Histone H3 (20-36) lysine 27 has been trimethylated which is usually a marker of repressive chromatin. H3K27 trimethylation also prevents H3 from interacting with SET1-like complexes, thus inhibiting the trimethylation of H3K4.

A synthetic peptide for use as a blocking control in assays to test for specificity of Tmed1 antibody, catalog no. 70R-8661

Catalogue peptide; min. 95% purity

Biotin-MOG (35-55) peptide is the biotinylated version of Mouse MOG (35-55) peptide which is used to induce the Experimental Autoimmune Encephalomyelitis (EAE) mouse model for T-cell-mediated inflammatory demyelinating autoimmune diseases of the CNS.

Conopressin S, isolated from Conus striatus, shows high affinity with vasopressin V1b receptor (AVPR1B), with a Ki of 8.3 nM.

Peptide H-ASGFTFMSSAVQWVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-ASGFTFMSSAVQWVR^-OH include the following: Comprehensive performance evaluation of ligand binding assay-LC-MS/MS method for co-dosed monoclonal anti-SARS-CoV-2 antibodies (AZD7442) Y Huang , MS Woolf, CC Wang, SM Naser - Bioanalysis, 2024 - Future Sciencehttps://www.future-science.com/doi/abs/10.4155/bio-2023-0225

Peptide H-YENYELTLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-YENYELTLK^-OH include the following: A rapid method for cross-species quantitation of apolipoproteins A1, B48 and B100 in plasma by ultra-performance liquid chromatography/tandem mass spectrometry ME Lassman, TM McLaughlin - Rapid , 2012 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/rcm.5296

A synthetic peptide for use as a blocking control in assays to test for specificity of PPP1R3B antibody, catalog no. 70R-10399

Peptide H-DQIPELENNEK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-DQIPELENNEK-OH include the following: Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass Y Chen, M Gruidl, E Remily-Wood, RZ Liu - Journal of proteome , 2010 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/pr1005197 Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue S Martaca­nez Martaca­n, V Castillo Cano, D Masso Valles - 2023 - scientiasalut.gencat.cathttps://scientiasalut.gencat.cat/bitstream/handle/11351/9181/pharmacokinetic_analysis_omomyc_shows_lasting_structural_integrity_long_terminal_half_life_tumor_tissue_2023.pdf?sequence=1 Pharmacokinetic analysis of omomyc shows lasting structural integrity and long terminal half-life in tumor tissue ME Beaulieu, S Martaca­nez-Martaca­n, J Kaur - Cancers, 2023 - mdpi.comhttps://www.mdpi.com/2072-6694/15/3/826?trk=public_post_main-feed-card-text

Peptide Ac-GLARS-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using Ac-GLARS-NH2 include the following: Polysaccharides for Bacterially Triggered System in Colon Targeting P Soni, GP Chaudhary, LK Soni - Current Research in , 2015 - crpsonline.comhttp://www.crpsonline.com/index.php/crps/article/view/144 Entire regularization path for sparse nonnegative interaction model M Takayanagi, Y Tabei , H Saigo - 2018 IEEE International , 2018 - ieeexplore.ieee.orghttps://ieeexplore.ieee.org/abstract/document/8594977/ Sparse nonnegative interaction models M Takayanagi, Y Tabei , E Suzuki , H Saigo - IEEE Access, 2021 - ieeexplore.ieee.orghttps://ieeexplore.ieee.org/abstract/document/9493878/ Thermosensitive mutants of Escherichia coli K-12 altered in the catalytic subunit and in a regulatory factor of the glutamy-transfer ribonucleic acid synthetase J Lapointe , G Delcuve - Journal of bacteriology, 1975 - Am Soc Microbiolhttps://journals.asm.org/doi/abs/10.1128/jb.122.2.352-358.1975 Association of lower circulating Spexin levels with higher body mass indices and glucose metabolic profiles in adult subjects in Egypt ES Albeltagy , NM Abd Elbaky - Human Nutrition & Metabolism, 2022 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S2666149721000190 An update on galanin and spexin and their potential for the treatment of type 2 diabetes and related metabolic disorders DM Gallagher, FPM O'Harte , N Irwin - Peptides, 2024 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0196978123001614 Emerging oral controlled-release technology for optimal therapy BJ Lee , JB Park - 2013 - Future Medicinehttps://www.futuremedicine.com/doi/abs/10.4155/ebo.13.376

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

A synthetic peptide for use as a blocking control in assays to test for specificity of LRRC8B antibody, catalog no. 70R-6538

Peptide LCBiot-LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using LCBiot-LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF-OH include the following: LC-MS/MS quantification of bioactive angiotensin I-converting enzyme inhibitory peptides in rye malt sourdoughs Y Hu , A Stromeck, J Loponen - Journal of agricultural , 2011 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jf2033329 4.9 Oxidation of 33-mer peptide X Huang , P Kanerva, H Salovaara - WORKING GROUP on , 2014 - wgpat.comhttps://www.wgpat.com/proceeding_28th.pdf#page=78 Evaluation of the usefulness of an automatable immunoassay for monitoring celiac disease by quantification of immunogenic gluten peptides in urine V Segura , aca Ruiz-Carnicer , I Mendaca­a - Nutrients, 2023 - mdpi.comhttps://www.mdpi.com/2072-6643/15/7/1730 Identification of celiac disease related immunogenic peptides in Norwegian wheat types after ex vivo digestion R Rehman - 2018 - nmbu.brage.unit.nohttps://nmbu.brage.unit.no/nmbu-xmlui/handle/11250/2582300 VPLIV AMINOKISLINSKIH SUBSTITUCIJ V ALFA-GLIADINSKIH PEPTIDIH NA NJIHOVO IMUNOGENOST PRI CELIAKIJI N JAPELJ - ffa.uni-lj.sihttps://www.ffa.uni-lj.si/fileadmin/datoteke/Knjiznica/diplome/2014/Japelj_Nika_dipl_nal_2014.pdf Defining the wheat gluten peptide fingerprint via a discovery and targeted proteomics approach MJ Martaca­nez-Esteso, J Norgaard, M Brohee - Journal of , 2016 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1874391916300719 Blocking celiac antigenicity of the glutamine-rich gliadin 33-mer peptide by microbial transglutaminase L Zhou , Y Wu, Y Cheng, J Wang, J Lu, J Gao, J Yuan - RSC , 2017 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2017/ra/c6ra27893k Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue L Shan , T Marti, LM Sollid , GM Gray - Biochemical , 2004 - portlandpress.comhttps://portlandpress.com/biochemj/article-abstract/383/2/311/77490 Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue L Shan , SW Qiao , H Arentz-Hansen - Journal of proteome , 2005 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/pr050173t 4.3 Quantitation of the 33-mer peptide from alpha-gliadins in wheat flours by LC-MS/MS K Schalk, C Lang, H Wieser, P Koehler , KA Scherf - WORKING GROUP on - wgpat.comhttps://www.wgpat.com/proceeding_30th.pdf#page=32 Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2 J Xia , LM Sollid , C Khosla - Biochemistry, 2005 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/bi047747c A complete mass spectrometry (MS)-based peptidomic description of gluten peptides generated during in vitro gastrointestinal digestion of durum wheat: Implication F Boukid , B Prandi , A Faccini - Journal of The American , 2019 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1007/s13361-019-02212-8 Recombinant Cathepsin L of Tribolium castaneum and Its Potential in the Hydrolysis of Immunogenic Gliadin Peptides EA Dvoryakova, MA Klimova, TR Simonyan - International Journal of , 2022 - mdpi.comhttps://www.mdpi.com/1422-0067/23/13/7001

CH3O-PEG-NH2 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. CH3O-PEG-NH2 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

A synthetic peptide for use as a blocking control in assays to test for specificity of NRBP1 antibody, catalog no. 70R-9295

Peptide H-FLEQELETITIPDLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-FLEQELETITIPDLR^-OH include the following: Parallel reaction monitoring (PRM) and selected reaction monitoring (SRM) exhibit comparable linearity, dynamic range and precision for targeted quantitative HDL GE Ronsein , N Pamir , PD von Haller, DS Kim - Journal of , 2015 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1874391914004990