Peptides

The Dystrophin protein, encoded by the dystrophin gene, is part of the dystrophin glycoprotein complex which connects the inner cytoskeleton to the extracellular matrix in muscle fibres. This allows the muscle cell plasma membrane to remain structurally stable.Forms of inherited muscular dystrophy such as Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) result from mutations targeting the dystrophin gene. These disorders are X-linked, progressive and cause the gradually weakening of the muscles leading to respiratory failure and ultimately reduces the patient lifespan.In DMD, mutations lead to the production of premature stop codons and hence the truncated dystrophin protein product is vulnerable to nonsense mediated decay and degradation. Therefore dystrophin production in muscle cells is reduced. On the other hand, nonsense mutations which also contribute to DMD, cause exon skipping in BMD and result in an internally truncated protein product which are partially functional. The symptoms of BMD are later onset compared with DMD which develop in patients between 2 to 7 years.

Eptifibatide is a drug that is used in the treatment of congestive heart failure, acute coronary syndrome and peripheral artery disease. It is a glycoprotein IIb/IIIa inhibitor that binds to integrin receptors on platelets and prevents them from binding to fibrinogen. This prevents blood clotting and reduces the risk of stroke or heart attack. Eptifibatide has been shown to be effective for the treatment of bowel disease, infectious diseases, and experimental models of myocardial infarcts. The drug has significant cytotoxicity, which may be due to its ability to inhibit cell proliferation by blocking protein synthesis at the ribosome level. Eptifibatide has been shown to have a disulfide bond between two cysteine residues located in its amino-terminal region. This bond stabilizes the molecule in solution and ensures that it remains active until it reaches its target site.

A synthetic peptide for use as a blocking control in assays to test for specificity of CNTD1 antibody, catalog no. 70R-4549

Peptide H-CDDYYYGFGCNKFCRPR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-CDDYYYGFGCNKFCRPR-OH include the following: Antifibrotic therapies to control cardiac fibrosis Z Fan , J Guan - Biomaterials research, 2016 - spj.science.orghttps://spj.science.org/doi/abs/10.1186/s40824-016-0060-8 GANT61 exerts anticancer cell and anticancer stem cell capacity in colorectal cancer by blocking the Wnt/beta"‘catenin and Notch signalling pathways Y Si, L Li, W Zhang, Q Liu, B Liu - Oncology Reports, 2022 - spandidos-publications.comhttps://www.spandidos-publications.com/10.3892/or.2022.8397 Biomaterial-mediated presentation of jagged-1 mimetic ligand enhances cellular activation of notch signaling and bone regeneration Y Deng, R Li , H Wang , B Yang, P Shi , Y Zhang - ACS , 2021 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acsnano.1c08728 Fetal dermal mesenchymal stem cell-derived exosomes accelerate cutaneous wound healing by activating notch signaling X Wang, Y Jiao, Y Pan, L Zhang, H Gong - Stem Cells , 2019 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1155/2019/2402916 Mitigation of pathological parameters under Jagged1 influence in DMD knockout zebrafish and patient-derived myoblast cultures V Nesari, J Vaishnav , S Sharma, U Nongthomba - 2023 - nopr.niscpr.res.inhttps://nopr.niscpr.res.in/handle/123456789/62534 Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis S Mittal, D Subramanyam, D Dey , RV Kumar - Molecular cancer, 2009 - Springerhttps://link.springer.com/article/10.1186/1476-4598-8-128 Tbx1 regulates brain vascularization S Cioffi, S Martucciello, FG Fulcoli - Human Molecular , 2014 - academic.oup.comhttps://academic.oup.com/hmg/article-abstract/23/1/78/722596 Notch Signaling Slows Down the Progression of Embryonic Myogenic Differentiation in Landrace S Cai, Q Zhu, B Hu, X Luo, R Yuan, F Liang, T Duo - 2020 - researchsquare.comhttps://www.researchsquare.com/article/rs-104072/latest Notch signaling leads to a slower progression of embryonic myogenic differentiation in Landrace than in Langtang pigs: Notch signaling prevents embryonic S Cai, B Hu, Q Zhu, T Duo, X Wang - Acta Biochimica et , 2022 - ncbi.nlm.nih.govhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827795/ Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis RCA Sainson , J Aoto , MN Nakatsu - The FASEB , 2005 - Wiley Online Libraryhttps://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.04-3172fje Self-assembling peptides as an emerging platform for the treatment of metabolic syndrome LA Castillo-Daca­az, JA Ruiz-Pacheco - International Journal , 2020 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.2147/IJN.S278189 Antifibrotic therapies to control cardiac fibrosis. pdf J Guan - 2019 - hra.figshare.comhttps://hra.figshare.com/articles/journal_contribution/Antifibrotic_therapies_to_control_cardiac_fibrosis_pdf/7800977/files/14519153.pdf Notch1 cardioprotection in myocardial ischemia/reperfusion involves reduction of oxidative/nitrative stress H Pei, Q Yu, Q Xue, Y Guo, L Sun, Z Hong - Basic Research in , 2013 - Springerhttps://link.springer.com/article/10.1007/s00395-013-0373-x Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells G Ferrari-Toninelli, SA Bonini, D Uberti - Neuro , 2010 - academic.oup.comhttps://academic.oup.com/neuro-oncology/article-abstract/12/12/1231/1130248 Induction of myogenic differentiation of human mesenchymal stem cells cultured on Notch agonist (Jagged-1) modified biodegradable scaffold surface F Wen , HK Wong, CY Tay , H Yu , H Li , T Yu - Applied Materials & , 2014 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/am4045635 Rational design of gold nanocarrier for the delivery of JAG-1 peptide CT Matea , T Mocan , F Tabaran , C Iancu - Journal of , 2015 - Springerhttps://link.springer.com/article/10.1186/s12951-015-0100-x Ex vivo culture of adult CD34+ stem cells using functional highly porous polymer scaffolds to establish biomimicry of the bone marrow niche CE Severn , AM Eissa , CR Langford , A Parker - Biomaterials, 2019 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0142961219306325

Peptide H-ITQSNAILR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-ITQSNAILR^-OH include the following: Proteomic identification, cDNA cloning and enzymatic activity of glutathione S-transferases from the generalist marine gastropod, Cyphoma gibbosum KE Whalen , D Morin, CY Lin , RS Tjeerdema - Archives of Biochemistry , 2008 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0003986108003342 Time-Dependent Measurement of Nrf2-Regulated Antioxidant Response to Ionizing Radiation Toward Identifying Potential Protein Biomarkers for Acute Radiation K Liu , E Singer, W Cohn, ED Micewicz - PROTEOMICS , 2019 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/prca.201900035 Accelerating the Development of Diagnostic Biomarkers and Mitigating Drugs for Radiation Injury with Quantitative Mass Spectrometry K Liu - 2019 - search.proquest.comhttps://search.proquest.com/openview/725d3368658901cca593cab1b2debe7c/1?pq-origsite=gscholar&cbl=18750&diss=y

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Peptide H-TFVNITPAEVGVLVGK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-TFVNITPAEVGVLVGK-OH include the following: Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells D Wang, DJ Jang - Cancer research, 2009 - AACRhttps://aacrjournals.org/cancerres/article-abstract/69/20/8200/550130

Asp-Asp-Asp-Asp-Asp acetate is a peptide consists of 5 Asp.

Peptide H-STEYGEGYACDTDLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-STEYGEGYACDTDLR^-OH include the following: Development and provisional validation of a multiplex LC-MRM-MS test for timely kidney injury detection in urine TT van Duijl , LR Ruhaak , NPM Smit - Journal of Proteome , 2021 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jproteome.1c00532 Development and characterization of a pseudo multiple reaction monitoring method for the quantification of human uromodulin in urine TG Hammond , S Moes, S Youhanna , P Jennings - Bioanalysis, 2016 - Future Sciencehttps://www.future-science.com/doi/abs/10.4155/bio-2016-0055

Peptide H-NAVEVLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-NAVEVLK^-OH include the following: T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8 MT Tran , P Faridi , JJ Lim , YT Ting , G Onwukwe - Nature , 2021 - nature.comhttps://www.nature.com/articles/s41467-021-25404-x Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes JAB Babon , ME DeNicola, DM Blodgett , I Cracašvecoeur - Nature medicine, 2016 - nature.comhttps://www.nature.com/articles/nm.4203

Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten.

A synthetic peptide for use as a blocking control in assays to test for specificity of ABCF2 antibody, catalog no. 70R-5703

Human chorionic gonadotropin (hCG) is a peptide hormone produced in pregnancy, that is made by the embryo soon after conception and later by the part of the placenta. Its role is to prevent the disintegration of the corpus luteum of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans. hCG may have additional functions, for instance it is thought that it affects the immune tolerance of the pregnancy. Early pregnancy testing generally is based on the detection or measurement of hCG.

Peptide H-NKGENAQAI-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-NKGENAQAI-OH include the following: Identification of a novel tumor-specific CTL epitope presented by RMA, EL-4, and MBL-2 lymphomas reveals their common origin T van Hall , J van Bergen, PA van Veelen - The Journal of , 2000 - journals.aai.orghttps://journals.aai.org/jimmunol/article/165/2/869/32951 Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants T van Hall , EZ Wolpert, P van Veelen, S Laban - Nature medicine, 2006 - nature.comhttps://www.nature.com/articles/nm1381 Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope LC Heukamp, T van Hall , F Ossendorp - Journal of , 2002 - journals.lww.comhttps://journals.lww.com/immunotherapy-journal/fulltext/2002/01000/effective_immunotherapy_of_cancer_in.5.aspx Identification of a Novel Tumor-Specific CTL CJM Melief , F Ossendorp , R Offringa, M Kraakman - J , 2000 - researchgate.nethttps://www.researchgate.net/profile/Lukas-Heukamp/publication/237234565_Origin_Lymphomas_Reveals_Their_Common_Presented_by_RMA_EL4_and_MBL2_Tumor-Specific_CTL_Epitope_Identification_of_a_Novel/links/0c96052789a5f06159000000/Origin-Lymphomas-Reveals-Their-Common-Presented-by-RMA-EL4-and-MBL2-Tumor-Specific-CTL-Epitope-Identification-of-a-Novel.pdf Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production B Kessler , X Hong, J Petrovic , A Borodovsky - Journal of Biological , 2003 - ASBMBhttps://www.jbc.org/article/S0021-9258(19)32470-6/abstract Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination B Chambers, P Grufman, V Fredriksson, K Andersson - Cancer research, 2007 - AACRhttps://aacrjournals.org/cancerres/article-abstract/67/18/8450/533487

Peptide H-HVPGGGSVQIVYK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-HVPGGGSVQIVYK-OH include the following: Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal-Type Phosphorylation of the Ï„ in Paired Helical M Hasegawa, A Watanabe, K Takio - Journal of , 1993 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.1993.tb03491.x O3-01-03: TAU KINETICS IN NEURONS AND IN THE HUMAN CNS C Sato , NR Barthelemy , KG Mawuenyega - Alzheimer's & , 2018 - Wiley Online Libraryhttps://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1016/j.jalz.2018.06.2772

Peptide H-VHLTPEEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using H-VHLTPEEK^-OH include the following: Analysis of oxidative and advanced oxidative modifications in hemoglobin of oral cancer patients by mass spectrometry YS Lin, CW Wu, TS Lin, NY Chen, DC Wu - Analytical , 2019 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.analchem.9b02743 Automated analytical system for the examination of protein primary structure YLF Hsieh, HQ Wang, C Elicone, J Mark - Analytical , 1996 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ac950421c A mass spectrometry assay for detection of endogenous and lentiviral engineered hemoglobin in cultured cells and sickle cell disease mice X Wang, WM McKillop, TA Dlugi - The Journal of Gene , 2024 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/jgm.3567 Chemical methods for the detection of protein N-homocysteinylation via selective reactions with aldehydes T Zang , S Dai , D Chen, BWK Lee, S Liu - Analytical , 2009 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ac9017132 Hb Lusaka [alpha131 (H14) Ser-> Phe (alpha1)]: A New Variant Found in a Woman Heterozygous for Hb S [beta6 (A3) Glu-> Val] SO Brennan, T Chan, C Sheen , L Rae - Hemoglobin, 2003 - Taylor & Francishttps://www.tandfonline.com/doi/full/10.1081/HEM-120023381 Structural analysis of peptide-acetaldehyde adducts by mass spectrometry and production of antibodies directed against nonreduced protein-acetaldehyde adducts RC Lin, JB Smith, DB Radtke - Alcoholism: Clinical and , 1995 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1530-0277.1995.tb01508.x O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: Structural and functional consequences of beta93Cys modification RA Boykins, PW Buehler , Y Jia - Proteins: Structure , 2005 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/prot.20453 Pressure-assisted and pressure-programmed capillary electrophoresis/electrospray ionization time of flight-mass spectrometry for the analysis of peptide mixtures P Cao, M Moini - Electrophoresis, 1998 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/elps.1150191226 -programmed capillary electrophoresis/electrospray ionization time of flight--Department of Chemistry and mass spectrometry for the analysis of peptide P Cao, M Moini - academia.eduhttps://www.academia.edu/download/46550198/elps.115019122620160616-1290-1p2nun8.pdf Acetaldehyde adducts of human hemo-globin: Identification of modified hemo-globin N-terminal peptides in blood sam-ples by LC/TOF-MS MG Wagner, SW Toennes , GF Kauert - gtfch.orghttps://gtfch.org/cms/images/stories/media/tb/tb2007/s363-373.pdf Ultraperformance liquid chromatography tandem mass spectrometry method to determine formaldehyde hemoglobin adducts in humans as biomarker for M Yang , M Ospina, C Tse, S Toth - Chemical research in , 2017 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.chemrestox.7b00114 Characterization of N-terminal formaldehyde adducts to hemoglobin M Ospina, A Costin, AK Barry - in Mass Spectrometry, 2011 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/rcm.4954 Limitations of mass spectrometry-based peptidomic approaches LD Fricker - Journal of the American Society for Mass , 2015 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1007/s13361-015-1231-x New validated method for quantification of glycated hemoglobin by LC-QToF-MS: is HRMS able to quantify clinical samples? LB Cerqueira, MM Fachi, WH Kawagushi - Journal of the , 2020 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/jasms.9b00049 Porphyromonas gingivalis Gingipains Display Transpeptidation Activity L Zhang, PD Veith , NL Huq, YY Chen - Journal of proteome , 2018 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jproteome.8b00286 Do dried blood spots have the potential to support result management processes in routine sports drug testing?-Part 3: LC-MS/MS-based peptide analysis for dried L Brockbals, A Thomas , TD Schneider - Drug testing and , 2023 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/dta.3463 Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism IA Lewis , M Wacker, KL Olszewski, SA Cobbold - PLoS , 2014 - journals.plos.orghttps://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004085 Assessment of microwave-assisted enzymatic digestion by measuring glycated hemoglobin A1c by mass spectrometry HW Vesper, L Mi, A Enada - Rapid Communications in , 2005 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/rcm.2135 Analytical approaches for quantification of a Nrf2 pathway activator: overcoming bioanalytical challenges to support a toxicity study HL Perez, V Junnotula , D Knecht, H Nie, Y Sanchez - Analyst, 2014 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2014/an/c3an02216a Sequence Mapping of Epoxide Adducts in Human Hemoglobin with LC-Tandem MS and the Salsa Algorithm H Badghisi, DC Liebler - Chemical research in toxicology, 2002 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/tx015589+ A new CE-ESI-MS method for the detection of stable hemoglobin acetaldehyde adducts, potential biomarkers of alcohol abuse GE De Benedetto, M Fanigliulo - Electrophoresis, 2009 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/elps.200800379 Mapping protein modifications with liquid chromatography-mass spectrometry and the SALSA algorithm DC Liebler , BT Hansen, JA Jones, H Badghisi - Advances in Protein , 2003 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0065323303010209 Evaluation of volumetric absorptive microsampling and mass spectrometry data-independent acquisition of hemoglobin-related clinical markers DA Lima, RA Schuch, JS Salgueiro - Journal of Proteome , 2022 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jproteome.1c00892 An improved stable isotope N-terminal labeling approach with light/heavy TMPP to automate proteogenomics data validation: dN-TOP D Bertaccini, S Vaca , C Carapito - Journal of proteome , 2013 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/pr4002993 HPLC-ESI-MS/MS analysis of hemoglobin peptides in tryptic digests of dried-blood spot extracts detects HbS, HbC, HbD, HbE, HbO-Arab, and HbG-Philadelphia CA Haynes, SL Guerra, JC Fontana, VR DeJesacaºs - Clinica chimica acta, 2013 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0009898113002489 16alpha-Hydroxyestrone: Mass spectrometry-based methodologies for the identification of covalent adducts formed with blood proteins C Charneira, J Nunes - Chemical research in , 2020 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.chemrestox.0c00171 Mass Spectrometry-Based Strategies for Assessing Human Exposure Using Hemoglobin Adductomics AT Rajczewski , L Ndreu, E Vryonidis - Chemical Research , 2023 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.chemrestox.3c00294 Sample preparation methods for targeted single-cell proteomics A Eshghi , X Xie , D Hardie, MX Chen - Journal of Proteome , 2023 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jproteome.2c00429

SV40 large T antigen NLS acetate is from Large T antigen residue 47 to 55, enables protein import into cell nucleus.

A synthetic peptide for use as a blocking control in assays to test for specificity of NXPH3 antibody, catalog no. 70R-4471