CAS: 10080-05-4

Impurity Glipizide EP Impurity H Applications 1-Cyclohexyl-3-(p-sulfamoylphenethyl)urea (Glipizide EP Impurity H) is an impurity of Glipizide (G410225). References Jurca, B. et al.: J. Therm. Anal. Calor., 62, 859 (2000);

4-(2-((Cyclohexylcarbamoyl)amino)ethyl)benzenesulfonamide is a research and development impurity standard that is used for the synthesis of drug products. CAS No. 10080-05-4, 4-(2-((Cyclohexylcarbamoyl)amino)ethyl)benzenesulfonamide is a synthetic compound that has been shown to be metabolized in humans and in rats. It has been extensively evaluated as a potential antituberculosis drug candidate and shown to inhibit bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. In vitro studies have demonstrated its efficacy against Mycobacter