CAS 109581-93-3: Idrato di tacrolimus
Descrizione:
Idrato di tacrolimus, con il numero CAS 109581-93-3, è un agente immunosoppressore utilizzato principalmente nel trapianto di organi e nelle malattie autoimmuni. È derivato dal batterio Streptomyces tsukubaensis e funziona inibendo l'attivazione dei linfociti T, riducendo così la risposta immunitaria. La sostanza appare come una polvere bianca o bianco sporco ed è solubile in solventi organici come il metanolo e il dimetilsolfossido, ma ha una solubilità limitata in acqua. Idrato di tacrolimus è spesso formulato come un unguento topico o un farmaco orale, a seconda della sua applicazione. I suoi effetti farmacologici sono attribuiti alla sua capacità di legarsi a FKBP-12, una proteina che inibisce successivamente la calcineurina, un enzima critico nell'attivazione delle cellule T. Sebbene efficace, il tacrolimus può avere effetti collaterali, tra cui nefrotossicità e maggiore suscettibilità alle infezioni, richiedendo un attento monitoraggio durante il trattamento. In generale, Idrato di tacrolimus è un agente terapeutico vitale nella gestione di condizioni che richiedono soppressione immunitaria.
Formula:C44H69NO12·H2O
InChI:InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1
InChI key:InChIKey=NWJQLQGQZSIBAF-MLAUYUEBSA-N
SMILES:O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@H](O)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H].O
Sinonimi:- (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone hydrate
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, hydrate (1:1), (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
- 18-Tetramethyl-8-(2-Propenyl)-,Monohydrate,(3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*
- 3-(2-(4-Hydroxy-3-Methoxycyclohexyl)-1-Methylethenyl)-14,16-Dimethoxy-9,10,12,Monohydrate
- FK-506 Monohydrate
- Tacforius
- Tacrolimus hydrate
- Tacrolimushydrate
- Tsukubaenolide hydrate
- Vedi altri sinonimi
Ordinare per
14 prodotti.
Tacrolimus Monohydrate
CAS:Formula:C44H69NO12·H2OPurezza:>80.0%(HPLC)Colore e forma:White to Almost white powder to crystalPeso molecolare:822.05Tacrolimus Hydrate
CAS:Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs) Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)Formula:C44H69NO12·H2OColore e forma:NeatPeso molecolare:822.03Ref: ST-EA-CP-T39005
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaTacrolimus monohydrate - Bio-X ™
CAS:Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties. Tacrolimus monohydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C44H69NO12·H2OPurezza:Min. 95%Colore e forma:PowderPeso molecolare:822.03 g/molTacrolimus
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C44H69NO12·H2OColore e forma:White PowderPeso molecolare:803.48198Tacrolimus monohydrate
CAS:Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.Formula:C44H71NO13Purezza:97.04% - 98.05%Colore e forma:SolidPeso molecolare:822.05FK-506 monohydrate
CAS:Formula:C44H69NO12·H2OPurezza:≥ 98.0%Colore e forma:White to off-white solid or powderPeso molecolare:822.03Tacrolimus monohydrate
CAS:Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerativeFormula:C44H69NO12·H2OPurezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:822.03 g/mol
