CAS 111470-99-6: besilato di amlodipina
Descrizione:
besilato di amlodipina è un bloccante dei canali del calcio utilizzato principalmente nel trattamento dell'ipertensione e dell'angina. È una polvere cristallina bianca o bianco sporco che è solubile in acqua e presenta un intervallo di pH di circa 6-8 in soluzione. La sostanza è un sale formato da amlodipina, un derivato della diidropiridina, e acido benzensolfonico, che ne migliora la solubilità e la stabilità. besilato di amlodipina agisce inibendo l'ingresso di ioni di calcio nel muscolo liscio vascolare e nel muscolo cardiaco, portando a vasodilatazione e riduzione della pressione sanguigna. La sua farmacocinetica indica una lunga emivita, consentendo una somministrazione una volta al giorno. Il composto è tipicamente somministrato per via orale ed è ben assorbito, con concentrazioni plasmatiche massime che si verificano diverse ore dopo l'ingestione. Gli effetti collaterali comuni possono includere edema periferico, vertigini e affaticamento. Come con qualsiasi farmaco, è essenziale considerare controindicazioni e potenziali interazioni con altri farmaci.
Formula:C20H25ClN2O5·C6H6O3S
InChI:InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChI key:InChIKey=ZPBWCRDSRKPIDG-UHFFFAOYSA-N
SMILES:C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1COCCN)C2=C(Cl)C=CC=C2.S(=O)(=O)(O)C1=CC=CC=C1
Sinonimi:- (±)-3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate monobenzenesulfonate
- 2-[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-3-Ethoxycarbonyl-5-Methoxycarbonyl-6-Methyl-1,4-Dihydropyridine Benzenesulfonate
- 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, benzenesulfonate (1:1)
- 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, monobenzenesulfonate
- 3-Ethyl 5-Methyl 2-[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate
- 3-Ethyl 5-Methyl 2-[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate Benzenesulfonate (1:1)
- 3-Ethyl 5-Methyl 2-[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate Methanesulfonate (1:1)
- AM Arya 5
- Alkapress
- Alopres
- Amcard
- Vedi altri sinonimi
Ordinare per
AMLODIPINE BESILATE CRS
CAS:AMLODIPINE BESILATE CRSFormula:C20H25ClN2O5Colore e forma:White. Whitish. Powder.Peso molecolare:408.8759Amlodipine besylate - USP Grade
CAS:Amlodipine besylate is a calcium channel blocker that is used to treat high blood pressure. It has a phase transition temperature of less than or equal to 100 degrees Celsius (212 degrees Fahrenheit). Amlodipine besylate should not be taken with other drugs that can affect the heart such as diuretics, angiotensin-converting enzyme inhibitors, and beta-blockers. The pharmacological effects of amlodipine besylate are similar to those of losartan. However, when amlodipine besylate is given orally for long periods of time, it shows greater efficacy in reducing blood pressure than losartan. This drug also has a low risk for interactions with other drugs when taken over a long period of time. Amlodipine besylate should not be used by people who have liver impairment because this medication may cause accumulation in the body and lead to serious side effects.Formula:C26H31ClN2O8SPurezza:Min. 95%Peso molecolare:567.05 g/molRef: 3D-FA173320
Prodotto fuori produzioneAmlodipine besilate
CAS:Amlodipine besilateFormula:C20H25ClN2O5 / C6H6O3SPurezza:72.0% / 99.9%Colore e forma:Light YellowPeso molecolare:408.1452 / 158.00377Amlodipine besylate
CAS:Inhibits L-type calcium channels; anti-hypertensive; antianginalFormula:C26H31ClN2O8SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:567.05 g/molAmlodipine Besylate
CAS:Formula:C20H25ClN2O5·C6H5SO3HPurezza:>98.0%(HPLC)(N)Colore e forma:White to Dark green powder to crystalPeso molecolare:567.05Amlodipine besylate - Bio-X ™
CAS:Amlodipine is a calcium channel blocker that is used to treat hypertension and angina. This drug inhibits the influx of calcium ions into both vascular smooth muscle and cardiac muscle. Amlodipine besylate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C20H25ClN2O5•C6H6O3SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:567.05 g/molAmlodipine Besylate
CAS:Compounds containing an unfused pyridine ring in the structure, nesoiFormula:C20H25ClN2O5·C6H6O3SColore e forma:White Light Yellow PowderPeso molecolare:566.14896Amlodipine besylate
CAS:Prodotto controllatoFormula:C20H25ClN2O5·C6H6O3SColore e forma:NeatPeso molecolare:567.05Amlodipine Besylate
CAS:Formula:C20H25ClN2O5·C6H6O3SColore e forma:White To Off-White SolidPeso molecolare:408.89 158.18Ref: 4Z-A-083
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaAmlodipine besylate, 98+%
CAS:Amlodipine besylate is used as a dihydropyridine calcium channel blocker. It is also used as an antianginal and antihypertensive. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C20H25ClN2O5·C6H5SO3HPurezza:98+%Peso molecolare:567.05Amlodipine Besylate
CAS:Applications Amlodipine Besylate is a dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive. References Arrowsmith, J.E., et al.: J. Med. Chem., 29, 1696 (1986); Burges, R.A., et al.: J. Cardiovasc Pharmacol., 9, 110 (1987); Packer, M., et al.: N. Engl. J. Med., 335, 1107 (1996);Formula:C20H25ClN2O5·C6H6O3SColore e forma:Light YellowPeso molecolare:567.05
