CAS 112022-83-0: (R)-2-Metil-CBS-ossazaborolidina
Descrizione:
(R)-2-Metil-CBS-ossazaborolidina è un composto organoboro chirale che funge da catalizzatore in varie reazioni di sintesi asimmetrica, in particolare nella formazione di legami carbonio-carbonio. Questo composto presenta un atomo di boro coordinato a una struttura di oxazaborolidina, che contribuisce alla sua reattività e selettività uniche nella catalisi. La presenza del gruppo metile nella posizione 2 migliora le sue proprietà steriche ed elettroniche, rendendolo efficace per reazioni enantioselettive. La sua natura chirale gli consente di favorire preferenzialmente la formazione di un enantiomero rispetto all'altro, il che è cruciale nella sintesi di prodotti farmaceutici e altri prodotti chimici fini. Il composto è tipicamente utilizzato in reazioni come la riduzione di chetoni e aldeidi, dove può facilitare la formazione di alcoli con un alto eccesso enantiomerico. Inoltre, (R)-2-Metil-CBS-ossazaborolidina è apprezzato per la sua stabilità e facilità di manipolazione, rendendolo una scelta popolare nella chimica organica sintetica. Le sue applicazioni si estendono a vari campi, inclusa la chimica medicinale e la scienza dei materiali, dove la chiralità gioca un ruolo significativo nelle proprietà e nelle attività dei composti risultanti.
Formula:C18H20BNO
InChI:InChI=1S/C18H20BNO/c1-19-20-14-8-13-17(20)18(21-19,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17H,8,13-14H2,1H3/t17-/m1/s1
InChI key:InChIKey=VMKAFJQFKBASMU-QGZVFWFLSA-N
SMILES:CB1OC([C@@]2(N1CCC2)[H])(C3=CC=CC=C3)C4=CC=CC=C4
Sinonimi:- (3AR)-1-methyl-3,3-diphenyl-3a,4,5,6-tetrahydropyrrolo[1,2-c][1,3,2]oxazaborole
- (3aR)-1-methyl-3,3-diphenyltetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole
- (3aR)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole
- (R)-(+)-2-Methyl-CBS-oxazaborolindine
- (R)-1-Methyl,3,3-Diphenyl-TETRAHYDRO-PYRROLO(1,2-C)(1,3,2)oxazaborole
- (R)-1-Methyl-3,3-diphenylhexahydropyrrolo[1,2-c]-[1,3,2]oxazaborole
- (R)-3,3-Diphenyl-1-MethylTETRAHYDRO-1H,3H-PYRROLO[1,2-C][1,3,2]oxazaborole
- (R)-3,3-Diphenyl-1-MethylTETRAHYDRO-3H-PYRROLO-[1,2-C][1,3,2]oxazaborole
- (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
- (R)-5,5-Diphenyl-2-Methyl-3,4-PROPANO-1,3,2-oxazaborolidine
- (R)-Me-CBS
- Vedi altri sinonimi
Ordinare per
11 prodotti.
(R)-(+)-2-Methyl-CBS-oxazaborolidine, 1M solution in toluene
CAS:Prodotto controllatoThis Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C18H20BNOColore e forma:Solution, Colorless to amberPeso molecolare:277.17(R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole
CAS:Formula:C18H20BNOPurezza:98%Colore e forma:LiquidPeso molecolare:277.1685(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, 1mol/L in Toluene
CAS:(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, 1mol/L in ToluenePurezza:0.97Colore e forma:SolutionPeso molecolare:277.17g/mol(R)-2-Methyl-CBS-oxazaborolidine, 1M soln. in toluene
CAS:(R)-2-Methyl-CBS-oxazaborolidine is used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2 symmetrical ferrocenyl diols, and propargyl alcohols. It is also used in a desymmetrizing reduction leading to (S)-4-hydroxycyclohexenone. It is useful in the production of stereospecific motifs such as α-hydroxy acids, α-amino acids, symmetrical ferrocenyl diols and propargyl alcohols. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C18H20BNOColore e forma:Clear colorless to pale yellow, LiquidPeso molecolare:277.17(R) -2-Methyl-CBS-oxazaborolidine - 1M solution in Toluene
CAS:(R) -2-Methyl-CBS-oxazaborolidine is a chiral, optically pure 2-methyl-CBS oxazaborolidine. It has been used as a reagent for the stereoselective synthesis of aldehydes. The (R)-2-methyl CBS-oxazaborolidine is prepared by the reaction of the corresponding boronic acid with hydrocyanic acid in toluene. The (S)-2-methyl CBS-oxazaborolidine can be obtained from the reaction of (S)-CBS with hydrocyanic acid in toluene. A high yield of product is obtained from this reaction, and it is an efficient way to synthesize aldehydes such as maxacalcitol, which are not readily available commercially.Formula:C18H20BNOPurezza:Min. 95%Colore e forma:Colourless To Yellow LiquidPeso molecolare:277.17 g/molRef: 3D-FM45785
Prodotto fuori produzione(R)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine
CAS:Formula:C18H20BNOPurezza:>97.0%(T)Colore e forma:White to Almost white powder to crystalPeso molecolare:277.17CALLERY™ (R)-Methyl oxazaborolidine, 1M in toluene
CAS:(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole, 0.9-1.1M in toluene [(R)-Methyloxazaborolidine] (R)-CBS CatalystFormula:C18H20BNOColore e forma:colorless to amber liq.Peso molecolare:277.17(R)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine (ca. 1mol/L in Toluene)
CAS:Formula:C18H20BNOColore e forma:Colorless to Light yellow clear liquidPeso molecolare:277.17(R)-(+)-2-Methyl-CBS-oxazaborolidine
CAS:(R)-(+)-2-Methyl-CBS-oxazaborolidine is a dpp-iv inhibitor that is a β-unsaturated ketone. It has been shown to inhibit the enzyme histone lysine demethylase, which may be involved in the regulation of bone mass. This compound also has a pharmacokinetic profile that is characterized by high oral bioavailability, low plasma protein binding, and rapid metabolism by liver enzymes. The reaction mechanism for this compound is based on the formation of an enolate carbanion. (R)-(+)-2-Methyl-CBS-oxazaborolidine can be synthesized with high stereoselectivity and yields from reactions with simple starting materials. This synthetic route also has a number of advantages over other methods: it does not require any protecting groups, it does not use toxic solvents such as dichloromethane or chloroform, and it can be performed in anhydrous conditionsFormula:C18H20BNOPurezza:Min. 95%Colore e forma:SolidPeso molecolare:277.17 g/mol(R)-Methyl oxazaborolidine 1M in toluene
CAS:Purezza:95.0%Colore e forma:Liquid, ClearPeso molecolare:369.32000732421875(R)-(+)-2-Methyl-CBS-oxazaborolidine, 1M solution in toluene, AcroSeal™
CAS:Prodotto controllatoThis Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C18H20BNOColore e forma:Liquid, Colorless to amberPeso molecolare:277.17
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