CAS 119-04-0: D-streptamina, O-2,6-diamino-2,6-didesossi-β-L-idopiranosil-(1→3)-O-β-D-ribofuranosil-(1→5)-O-[2,6-diamino-2,6-didesossi-α-D-glucopiranosil-(1→4)]-2-desossi-
Descrizione:
La D-Streptamina è un antibiotico aminoglicosidico che svolge un ruolo significativo nel trattamento di varie infezioni batteriche. È caratterizzata dalla sua complessa struttura glicosidica, che include molteplici componenti di zuccheri amino e desossisaccaridi, contribuendo alla sua attività biologica. Il composto presenta un'organizzazione unica di moieties di zucchero, specificamente un'unità di β-L-idopiranosile e un'unità di β-D-ribofuranosile, collegate tramite legami glicosidici. La D-Streptamina mostra un'alta affinità per i ribosomi batterici, inibendo la sintesi proteica, che è cruciale per la crescita e la replicazione batterica. Il suo meccanismo d'azione coinvolge principalmente il legame con la subunità ribosomiale 30S, portando a una lettura errata dell'mRNA e, in ultima analisi, risultando nella produzione di proteine non funzionali. Questo antibiotico è particolarmente efficace contro i batteri Gram-negativi ed è spesso utilizzato in combinazione con altri antibiotici per migliorare l'efficacia terapeutica. Tuttavia, il suo uso è limitato dalla potenziale nefrotossicità e ototossicità, richiedendo un attento monitoraggio durante il trattamento. Nel complesso, la D-Streptamina rimane un composto importante nel campo della terapia antimicrobica.
Formula:C23H46N6O13
InChI:InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChI key:InChIKey=PGBHMTALBVVCIT-VCIWKGPPSA-N
SMILES:O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N
Sinonimi:- <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D</span>-ribofuranosyl-(1→5)]-2-deoxy-
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2,6-diamino-2,6-dideoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-
- Actilin
- Actiline
- Antibiotic 10676
- Antibiotique EF 185
- D-Streptamine, O-2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-
- Dekamycin III
- Enterfram
- Fradiomycin B
- Framicetina
- Vedi altri sinonimi
Ordinare per
6 prodotti.
Neomycin B
CAS:Neomycin B is an aminoglycoside antibiotic, which is derived from the bacterium *Streptomyces fradiae*. It exerts its antibacterial effects by binding to the 30S subunit of bacterial ribosomes, leading to the inhibition of protein synthesis. This binding disrupts the translation process, thereby preventing the growth and proliferation of bacteria. Neomycin B is effective against a wide range of Gram-negative and some Gram-positive bacteria, making it a valuable tool in both medical and research settings. The primary uses of Neomycin B include its application in topical formulations to prevent or treat skin infections. It is also used as an oral treatment to reduce the risk of intestinal bacterial infections before surgery or in hepatic encephalopathy management. In scientific research, Neomycin B may be used in cell culture media to maintain bacterial contamination-free environments. Its mechanism of action and broad-spectrum effectiveness continue to make it a subject of study within microbiology and pharmacology for further therapeutic developments.Formula:C23H46N6O13Purezza:Min. 95%Peso molecolare:614.64 g/molNeomycin solution - 10mg/mL neomycin in 0.9% NaCl
CAS:Aminoglycoside antibiotic; interferes with protein synthesisPurezza:Min. 95%Framycetin sulphate
CAS:Framycetin sulphate is a broad-spectrum antibiotic that is used to treat microbial infections. It has been shown to be effective against many gram-positive and gram-negative bacteria, including methicillin resistant Staphylococcus aureus. Framycetin sulphate prevents bacterial growth by inhibiting protein synthesis through binding to the 30S ribosomal subunit. This binding inhibits the incorporation of amino acids into proteins, thereby preventing the production of new proteins required for cell division and growth. Framycetin sulphate also has preservative properties, which may be due to its ability to chelate metal ions such as copper and iron. Framycetin sulphate can be administered orally or topically in vivo model studies. The drug was not found to have any significant toxic effects on the liver or kidneys in vivo model studies at concentrations up to 40%.Formula:C23H52N6O25S3Purezza:Min. 95%Peso molecolare:908.88 g/molFramycetin
CAS:Framycetin is an aminoglycoside antibiotic and it also inhibits hammerhead ribozyme (Ki: 13.5 μM).Formula:C23H46N6O13Purezza:98%Colore e forma:Amorphous SolidPeso molecolare:614.64Neomycin B
CAS:Prodotto controllatoStability Hygroscopic Applications Neomycin C is an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. References Umezawa, S., et al.: Bull. Chem. Soc. Jpm., 53, 3259 (1980); The Journal of antibiotics, NO. 2. 189 (1977);Formula:C23H46N6O13Colore e forma:NeatPeso molecolare:614.64Neomycin B Hexaacetate
CAS:Prodotto controllatoFormula:C23H46N6O13Colore e forma:NeatPeso molecolare:614.64
