CAS 127-07-1: Idrossiurea
Descrizione:
Idrossiurea, con il numero CAS 127-07-1, è un composto chimico che funge da agente antineoplastico, utilizzato principalmente nel trattamento di alcuni tumori, come la leucemia mieloide cronica e i tumori della testa e del collo, oltre a essere impiegato nella gestione della malattia delle cellule falciformi. È un solido cristallino bianco solubile in acqua e presenta una formula molecolare di C₄H₈N₂O₂. Idrossiurea agisce come inibitore della ribonucleotide reduttasi, interrompendo la sintesi del DNA impedendo la conversione dei ribonucleotidi in desossiribonucleotidi, inibendo così la proliferazione cellulare. Il composto è anche noto per la sua capacità di aumentare i livelli di emoglobina fetale nei pazienti con malattia delle cellule falciformi, il che può ridurre la frequenza delle crisi dolorose. Idrossiurea viene tipicamente somministrato per via orale e può avere effetti collaterali, tra cui mielosoppressione, disturbi gastrointestinali e potenziali effetti teratogeni, richiedendo un attento monitoraggio durante il trattamento. Il suo meccanismo d'azione e le applicazioni terapeutiche lo rendono un agente significativo in oncologia e ematologia.
Formula:CH4N2O2
InChI:InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI key:InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N
SMILES:C(NO)(N)=O
Sinonimi:- 1-Hydroxyurea
- Amino(Oxido-Λ5-Azanyl)Methanone
- Biosupressin
- Carbamohydroxamic acid
- Carbamohydroximic acid
- Carbamoyl oxime
- Carbamyl hydroxamate
- Cytodrox
- Droxia
- HU
- Hidrix
- Vedi altri sinonimi
Ordinare per
18 prodotti.
Hydroxycarbamide CRS
CAS:Hydroxycarbamide CRSFormula:CH4N2O2Colore e forma:Crystalline Powder. White. Powder.Peso molecolare:76.0547Ref: ST-EA-CP-F32011
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaHydroxyurea
CAS:Formula:CH4N2O2Purezza:98.0 - 102.0 % (anhydrous basis)Colore e forma:White to off-white powderPeso molecolare:76.06Hydroxyurea
CAS:Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.Formula:CH4N2O2Purezza:99.85% - 99.92%Colore e forma:SolidPeso molecolare:76.05Hydroxycarbamide
CAS:HydroxycarbamideFormula:CH4N2O2Purezza:99.6%Colore e forma:Off-WhitePeso molecolare:76.02728Hydroxyurea, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:CH4N2O2Purezza:98%Colore e forma:Crystalline powder, White to almost whitePeso molecolare:76.06Hydroxy Urea
CAS:Prodotto controllatoStability Hygroscopic Applications An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),Formula:CH4N2O2Colore e forma:White SolidPeso molecolare:76.05Hydroxyurea
CAS:HydroxyureaFormula:CH4N2O2Purezza:98%Colore e forma: white solidPeso molecolare:76.05g/molRef: 4Z-U-061
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaHydroxyurea
CAS:Hydroxyurea is a prodrug that is activated by the enzyme Jak2, which is found in the mitochondria of cells. Hydroxyurea is used to treat various types of cancer and other diseases, such as sickle cell anemia. It has been shown to be effective in inhibiting the growth of squamous cell carcinomas and myeloid leukemia cells. Hydroxyurea has also been shown to have synergistic effects when combined with other pharmacological agents, such as hydroxycarbamide and cytosine arabinoside. Hydroxyurea inhibits the production of energy in the form of ATP, which leads to death by apoptosis or necrosis. This drug also has inhibitory properties against bacterial infections, especially those caused by Mycobacterium tuberculosis and Mycobacterium avium complex.Formula:CH4N2O2Purezza:Min. 97.5 Area-%Colore e forma:White Off-White PowderPeso molecolare:76.06 g/molHydroxyurea
CAS:Formula:CH4N2O2Purezza:>97.0%(HPLC)(N)Colore e forma:White to Almost white powder to crystalPeso molecolare:76.06Hydroxyurea, 98%
CAS:Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia and recurrent metastatic or inoperable ovarian. It is also involved in reducing the rate of painful attacks in sickle-cell disease and has anti-retroviral properties in diseases such as AIDS. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:CH4N2O2Purezza:98%Colore e forma:White to cream or yellow, Crystals or powder or crystalline powderPeso molecolare:76.06Hydroxyurea
CAS:Purezza:98.00%Colore e forma:Solid, White crystalline powderPeso molecolare:76.05500030517578Hydroxyurea
CAS:Non-aromatic organic derivatives of hydrazine or of hydroxylamine for use as drugsFormula:CH4N2O2Colore e forma:White Off-White PowderPeso molecolare:76.06 g/mol
