CAS: 1292296-09-3

Compounds containing an unfused pyridine ring in the structure, nesoi

8-epiAtazanavir is a stereoisomer of the antiretroviral drug Atazanavir, which is derived from synthetic sources. It acts as an HIV-1 protease inhibitor, where it binds to the active site of the viral protease enzyme, thereby preventing the cleavage of precursor proteins required for the maturation of infectious viral particles. This interference with viral replication is achieved by the structural mimicry of the natural substrate of the protease, allowing it to competitively inhibit the enzyme's activity. The applications of 8-epiAtazanavir are primarily in the field of HIV research, where it is utilized to investigate the stereochemistry and efficacy of protease inhibitors. Researchers may employ this compound in studies that assess the impact of stereochemistry on drug action and resistance profiles. Additionally, it provides insights into the design and development of novel therapeutics targeting viral proteases, contributing to the optimization of antiretroviral therapies. Its specific role as an isomer makes it a valuable tool in comparative analyses with the more widely used Atazanavir.

Impurity Atazanavir Impurity 1 Applications An epimeric impurity of Atazanavir, novel azapeptide HIV protease inhibitor. Atazanavir Impurity 1 References Chitturi, S.R. et al.: J. Pharmac. Biomed. Anal., 55, 31 (2011);