CAS 136572-09-3: Cloridrato di irinotecano triidrato

Descrizione:

Cloridrato di irinotecano triidrato è un agente chemioterapico utilizzato principalmente nel trattamento del cancro colorettale. È un sale solubile in acqua derivato dall'alcaloide naturale camptotecina e funge da inibitore della topoisomerasi I, interrompendo la replicazione e la trascrizione del DNA nelle cellule tumorali. La sostanza appare come una polvere cristallina bianca a bianco sporco ed è igroscopica, il che significa che può assorbire umidità dall'ambiente. La sua formula molecolare include un componente cloridrato e tre molecole d'acqua, contribuendo alla sua stabilità e solubilità in soluzioni acquose. L'irinotecano viene somministrato per via endovenosa ed è spesso utilizzato in combinazione con altri agenti chemioterapici per aumentare l'efficacia. Gli effetti collaterali comuni includono diarrea, nausea e mielosoppressione, richiedendo un attento monitoraggio durante il trattamento. La farmacocinetica del composto implica un metabolismo principalmente da parte del fegato, con metaboliti attivi che contribuiscono ai suoi effetti terapeutici e tossicità. In generale, Cloridrato di irinotecano triidrato gioca un ruolo significativo in oncologia, in particolare nella gestione dei tumori in stadi avanzati.

Formula:C₃₃H₃₈N₄O₆·ClH·3H₂O

InChI:InChI=1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1

InChI key:InChIKey=KLEAIHJJLUAXIQ-JDRGBKBRSA-N

SMILES:C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OC(=O)N6CCC(CC6)N7CCCCC7)=CC5.Cl.O

Sinonimi:

(+)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, monohydrochloride, trihydrate
(+)-7-Ethyl-10-hydroxycamptothecine 10-(1,4'-bipiperidine)-1'-carboxylate, monohydrochloride, trihydrate
(1,4'-Bipiperidine)-1'-Carboxylicacid,4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hyd Monohydrochloride, Trihydrate
(1,4'-Bipiperidine)-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-
(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl [1,4'-bipiperidine]-1'-carboxylate trihydrate hydrochloride
(S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
(S)-[1,4'-Bipiperidine]-1'-Carboxylic Acid 4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano
(S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline, [1,4′-bipiperidine]-1′-carboxylic acid deriv.
Camptosar
Irinotecan HCl trihydrate
Irinotecan Monohydrochloride Trihydrate
Irinotecan hydrochloride hydrate
Irinotecanhydrochloridetrihydrate(Cpt-11)
Onivyde
Onivyde pegylated liposomal
Roxy-3,14-Dioxo-1H-Pyrano(3',4',6,7)Indolizino(1,2-B)Quinolin-9-Ylester,Mono
Trihydrate,(S)-Hydrochlorid Trihydrate
[1,4'-Bipiperidine]-1'-Carboxylic Acid (S)-4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano
[1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride, hydrate (1:1:3)
[1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, hydrochloride, hydrate (1:1:3)
[1,4′-Bipiperidine]-1′-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, trihydrate
[1,4′-Bipiperidine]-1′-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-
[3',4',6,7]Indolizino[1,2-B]Quinolin-9-Yl Ester, Hcl Trihydrate
Vedi altri sinonimi

prodotti per pagina.22 prodotti.

+ Info
Irinotecan hydrochloride trihydrate, 99%
CAS:
- 136572-09-3
Topoisomerase I inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Formula:C₃₃H₄₅ClN₄O₉
Purezza:99%
Peso molecolare:677.19
Ref: 02-J62370
100mg
Prezzo su richiesta
IVA esclusa
Aggiungere al carrello
250mg
Prezzo su richiesta
IVA esclusa
Aggiungere al carrello
+ Info
Irinotecan hydrochloride trihydrate
CAS:
- 136572-09-3
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Formula:C₃₃H₄₅ClN₄O₉
Colore e forma:Powder, Yellow
Peso molecolare:677.19
Ref: AC-46154
1g
Fuori produzione
Richiedi informazioni
250mg
Fuori produzione
Richiedi informazioni
Prodotto fuori produzione

CAS 136572-09-3: Cloridrato di irinotecano triidrato

Irinotecan hydrochloride trihydrate, 99%

Ref: 02-J62370

Irinotecan hydrochloride trihydrate

Ref: AC-46154