CAS: 1446322-66-2

Tat-cyclo-cllfvy is a cell-penetrating peptide, which is a synthetic compound designed for therapeutic applications. It is derived from natural peptide sequences, engineered to facilitate efficient cellular uptake without significant toxicity or disruption of cellular membranes. The mode of action involves the facilitated transport of the peptide across the lipid bilayer of cells, leveraging its amphipathic structure to interact with cellular membranes and enable intracellular delivery of attached therapeutic agents. The primary uses and applications of Tat-cyclo-cllfvy are in the fields of drug delivery and biochemical research. It serves as a vector for delivering a variety of molecular cargoes, including small molecules, proteins, and nucleic acids, into cells. This capability is particularly valuable for targeting intracellular pathways and investigating cellular responses, making it a crucial tool for the development of novel therapeutics and the study of complex biological systems. The ability to modify and attach different types of therapeutic agents makes Tat-cyclo-cllfvy a versatile and powerful agent in advanced biomedical research and therapy development.

Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).