CAS: 1599432-08-2

(E)-3-(4-Bromophenyl)-1-(4-(4-Methoxybenzoyl)Piperazin-1-Yl)Propan-2-En-1-One

Applications (2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one recently known as NIBR 189, is a selective Epstein-barr virus-induced gene 2 (EBI-2) receptor antagonist, resulting in a modulation of immune responses related to auto-immune diseases. References Gessier, F. et al.: J. Med. Chem., 57, 3358 (2014);

NIBR189 is a highly potent antiviral compound with a wide range of applications. It is a perfluorinated alkaloid that exhibits strong antiviral activity against various viruses. NIBR189 has been extensively studied for its ability to inhibit viral replication and has shown promising results in preclinical trials. One of the key features of NIBR189 is its solubility in various solvents, including aluminum, biosolids, and perchloroethylene. This makes it highly versatile and easy to incorporate into different formulations. Additionally, NIBR189 has been found to be miscible in both organic and aqueous solvents, further enhancing its usability. The mechanism of action of NIBR189 involves inhibiting the thymidylate synthase enzyme, which is essential for DNA synthesis in viruses. By targeting this enzyme, NIBR189 effectively disrupts viral replication and prevents the spread of infection. Furthermore, NIBR189 has shown potent inhibitory

NIBR189 is a potent and selective antagonist of EBI2 (GPR183) receptor (IC50 of 11 and 15 nM for human and mouse EBI2 receptors, respectively)

NIBR189