CAS: 1693766-04-9

GSK8573 is a small molecule that inhibits the bromodomain and has been shown to have potential as a cancer drug. GSK8573 binds to the bromodomain of the BRD4 protein, which is found in high levels in some cancer cells. This binding inhibits gene transcription, leading to cell death. The pharmacokinetic properties of GSK8573 have been studied in rats, dogs, and monkeys and show that it can cross the blood-brain barrier. However, more research is needed on its pharmacokinetic properties in humans. BRD4 is also involved with RNA synthesis and is found in high levels in some cancer cells. GSK8573 may also inhibit these processes, which would make it an effective treatment for cancer.

GSK8573

GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).