CAS: 172907-03-8

ZD-6888 Hydrochloride (ZD-6888 HCl) is an angiotensin II antagonist that mediates AII receptor blockade and induces AII-mediated inhibition of renin release.

PB 28 dihydrochloride is a selective sigma-2 receptor ligand, which is a synthetic compound targeting specific receptor sites. These receptors are predominantly found in cancer cells, implicating them in cellular proliferation and apoptosis. PB 28 dihydrochloride is synthetically derived and is employed extensively in preclinical studies. Its mode of action involves high-affinity binding to the sigma-2 receptors, allowing modulation of cellular stress responses and apoptosis pathways. Predominantly utilized in oncology research, PB 28 dihydrochloride provides valuable insights into cancer biology. By influencing cancer cell viability, it aids in the understanding of tumor progression and offers potential as a therapeutic lead. Additionally, it facilitates the investigation of sigma receptor functions and their role in various physiological processes. Such studies are foundational in developing novel therapeutic strategies targeting cancer and other diseases characterized by abnormal cell growth and division.