CAS: 175026-96-7

NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).

Applications NQDI-1 is an ASK1 inhibitor which is of therapeutic potential against acute ischemic renal injury.  Its protective effects are mediated through inhibition of apoptosis and oxidative stress. References El Eter, E.: Cardiov. Hematol. Agent Med. Chem., 11, 179 (2013)

NQDI-1

NQDI-1

NQDI 1 is a dinucleotide phosphate that activates the apoptosis pathway and induces reactive oxygen species. This experimental model has been shown to induce apoptosis in cells by activating pro-apoptotic protein, such as caspase 3, and inhibiting anti-apoptotic proteins, such as Bcl-2. NQDI 1 has also been shown to increase the activity of MMP-9, an enzyme that degrades extracellular matrix proteins. NQDI 1 may have potential use in cancer therapy because it induces autophagy and senescence in cancer tissues. Histological analysis of tumor tissue from mice treated with NQDI 1 showed necrosis and decreased cell proliferation. M2 phenotype: A phenotype characterized by a macrophage with a high capacity for phagocytosis, low production of cytokines, low expression of costimulatory molecules on the surface membrane and low levels of inflammatory mediators.