CAS: 1783978-03-9

PNU-177864 hydrochloride

PNU-177864 is a peptide that inhibits the activity of the Kv1.3 channel, which is an ion channel that regulates potassium ion flow across the cell membrane. This inhibition has been shown to reduce the release of neurotransmitters such as glutamate and glycine, which are thought to be involved in the development of chronic pain. PNU-177864 has also been shown to activate a number of receptors, including opioid receptors and serotonin receptors. The receptor activation leads to inhibition of protein synthesis and cellular proliferation.

PNU-177864 hydrochloride is a potent, selective and orally active antagonist of dopamine D3 receptor.