CAS 208538-73-2: Sodio di Micafungina
Descrizione:
Sodio di Micafungina è un agente antifungino appartenente alla classe delle echinocandine, utilizzato principalmente nel trattamento delle infezioni fungine invasive, in particolare quelle causate da specie di Candida e Aspergillus. Funziona inibendo la sintesi di β-(1,3)-D-glucano, un componente essenziale della parete cellulare fungina, compromettendo così l'integrità strutturale del fungo e portando alla lisi cellulare. La micafungina viene tipicamente somministrata per via endovenosa ed è caratterizzata dalla sua attività ad ampio spettro contro vari patogeni fungini, rendendola un'opzione preziosa in contesti clinici, specialmente per i pazienti immunocompromessi. La sostanza è solubile in acqua e mostra stabilità in condizioni fisiologiche. La sua farmacocinetica prevede una emivita relativamente lunga, consentendo una somministrazione una volta al giorno. Gli effetti collaterali comuni possono includere reazioni correlate all'infusione, elevazioni degli enzimi epatici e disturbi gastrointestinali. A causa del suo meccanismo d'azione e del profilo di sicurezza, la micafungina è spesso preferita nei casi in cui altre terapie antifungine possono essere meno efficaci o controindicate.
InChI:InChI=1/C56H71N9O23S.Na/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76;/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85);/q;+1/p-1/t25-,26-,31+,34?,35-,37+,38+,42-,43-,44-,45-,46-,47+,48?,52-;/m1./s1
SMILES:CCCCCOc1ccc(cc1)c1cc(c2ccc(cc2)C(=O)NC2CC(C(N=C(C3C(C(C)CN3C(=O)C(C(CC(=N)O)O)N=C(C(C(C(c3ccc(c(c3)OS(=O)(=O)O)O)O)O)N=C(C3CC(CN3C(=O)C(C(C)O)N=C2O)O)O)O)O)O)O)O)no1.[Na]
Sinonimi:- Fk 463
- 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((1R)-3-Amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((1R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-((4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoyl)amino)tetracosahydro-1H-dipyrrolo(2,1-c:2',1'-l)(1,4,7,10,13,16)hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sodium sulfate
- Fk463
- Unii-Is1Up79R56
- Pneumocandin A0, 1-((4R,5R)-4,5-dihydroxy-N2-(4-(5-(5-(pentyloxy)phenyl)-3-isoxazolyl)benzoyl)-L-ornithine)-4-((4S)-4-hydroxy-4-(4-hydroxy-3-(sulfooxy)phenyl)-L-threonine)-, monosodium salt
Ordinare per
11 prodotti.
Micafungin-¹³C₆ Sodium
CAS:Prodotto controllatoFormula:C50C6H70N9NaO23SColore e forma:NeatPeso molecolare:1298.22Micafungin Sodium
CAS:Formula:C56H70N9O23SNaPurezza:≥97% (HPLC)Colore e forma:white to beige powderPeso molecolare:1292.26Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-, sodium salt (1:1)
CAS:Formula:C53H67N8O20SPurezza:98%Colore e forma:SolidPeso molecolare:1168.2057Micafungin sodium - Bio-X ™
CAS:Micafungin, as one of three echinocandina, has been proven to be a successful antifungal therapeutic in treating general Candida fungus infections. The treatment of immunocompromised patients is particularly important as Candida infections cause high mortality rates in patients in intensive care units, receiving chemotherapy, or stem cell transplants. This product acts as an anti-fungal by inhibiting the 1,3-beta-D-glucan synthase enzyme. As a result the production of 1,3-beta-D-glucan, which is crucial to the fungal cell wall, is hindered. Thus, the fungal cell wall loses integrity allowing for osmotic instability and cell lysis to occur. Micafungin sodium is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C56H71N9O23S•NaPurezza:Min. 95%Colore e forma:PowderPeso molecolare:1,293.27 g/molMicafungin Sodium (INTERNATIONAL COLD SHIPMENT REQUIRED)
CAS:Antibiotics nesoiFormula:C56H70N9NaO23SColore e forma:White PowderPeso molecolare:1291.4203Micafungin sodium
CAS:Micafungin sodium (FK 463) is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetriFormula:C56H70N9NaO23SPurezza:98% - 99.6%Colore e forma:SolidPeso molecolare:1292.26Ref: TM-T1794
2mg47,00€5mg69,00€10mg105,00€25mg205,00€50mg329,00€100mg525,00€500mg1.159,00€1mL*10mM (DMSO)150,00€Micafungin sodium
CAS:Formula:C56H71N9O23S·NaPurezza:≥ 98.0% (anhydrous)Colore e forma:White to off-white or beige powderPeso molecolare:1292.28Micafungin Sodium Salt
CAS:Formula:C56H70N9O23S·NaColore e forma:White To Off-White Solid SolidPeso molecolare:1269.29 22.99Ref: 4Z-PM-127001
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaMicafungin-d11 Sodium
CAS:Prodotto controllatoApplications Micafungin-d11 Sodium is the isotope labelled analog of Micafungin Sodium (M342350); an echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall. Micafungin Sodium also represents a valuable treatment option for fungal infections. References Chen, S.C. et al.: Drugs, 71, 11 (2011); Groll, A.H. et al.: Opin. Anti-Infect. Invest. Drugs, 2, 405 (2000); Tomishima, M. et al.: J. Antibiot., 52, 674 (1999)Formula:C56H59D11N9NaO23SColore e forma:NeatPeso molecolare:1303.33Micafungin Sodium
CAS:Stability Hygroscopic Applications An echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, and represent a valuable treatment option for fungal infections. References Chen, S.C. et al.: Drugs, 71, 11 (2011); Groll, A.H. et al.: Opin. Anti-Infect. Invest. Drugs, 2, 405 (2000); Tomishima, M. et al.: J. Antibiot., 52, 674 (1999);Formula:C56H70N9O23S·NaColore e forma:Off WhitePeso molecolare:1292.26Micafungin sodium
CAS:Anti-fungal; glucan synthase inhibitorFormula:C56H70N9NaO23SPurezza:Min. 97 Area-%Colore e forma:White PowderPeso molecolare:1,292.26 g/mol
![Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-o…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA002JQV.jpg&w=3840&q=75)
