CAS 26305-03-3: pepstatina A ~120'000 U/mg
Descrizione:
La pepstatina A è un potente e selettivo inibitore delle aspartil proteasi, in particolare della renina e della pepsina, ed è derivata dalla fermentazione di alcune specie del batterio *Streptomyces*. È caratterizzata dalla sua struttura unica, che include uno scheletro peptidico con una sequenza specifica che le consente di legarsi efficacemente ai siti attivi degli enzimi target, inibendo così la loro attività. La sostanza ha un peso molecolare di circa 1.000 Da ed è spesso utilizzata nella ricerca biochimica per studiare processi proteolitici e cinetica enzimatica. La pepstatina A mostra alta specificità e affinità per le aspartil proteasi, rendendola uno strumento prezioso sia nella ricerca di base che applicata, inclusi studi relativi alla digestione delle proteine e alla regolazione. La sua efficacia è spesso quantificata in unità di inibizione, come "120.000 U/mg", che indica la sua potenza. Inoltre, è importante maneggiare la pepstatina A con cura, poiché può avere effetti biologici, e sono necessarie condizioni di stoccaggio adeguate per mantenere la sua stabilità e attività.
Formula:C34H63N5O9
InChI:InChI=1/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23+,24-,25-,26+,30-,31-/m1/s1
Sinonimi:- Pepstatin A
- pepstatin A from microbial source
- Pepstatin (microbial product)
- Isovaleryl-Val-Val-Sta-Ala-Sta-OH
- N-(3-methylbutanoyl)-L-valyl-N-[(1S,2S)-4-{[(1S)-2-({(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl}amino)-1-methyl-2-oxoethyl]amino}-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide
- (3S,4R)-3-hydroxy-4-[[(2R)-2-[[(3R,4S)-3-hydroxy-6-methyl-4-[[(2R)-3-methyl-2-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methyl-heptanoic acid
- Pepstatin
Ordinare per
12 prodotti.
Pepstatin A
CAS:Please enquire for more information about Pepstatin A including the price, delivery time and more detailed product information at the technical inquiry form on this pageFormula:C34H63N5O9Purezza:Min. 98 Area-%Colore e forma:PowderPeso molecolare:685.90 g/molPepstatin A (Synthetic)
CAS:Pepstatin A is a natural product that has been synthesized for use as an inhibitor of proteolytic enzymes. It inhibits the activity of a wide range of proteases and is used in vitro to study the biochemical properties of these enzymes. Pepstatin A inhibits the activity of many important proteases, including those involved in infectious diseases, such as HIV and hepatitis C virus. Pepstatin A binds to the active site on serine proteases, blocking access by their substrates and thereby inhibiting enzyme activity. The binding site is highly conserved among different types of serine protease, with approximately 90% homology between trypsin and chymotrypsin. The inhibitory mechanism involves a specific interaction between pepstatin A's hydrophobic side chain and the catalytic triad residues His57, Asp102, and Ser195 in trypsin or His57, Asp102, and Ser188 in chymotrypsin.Formula:C34H63N5O9Purezza:Min. 95%Peso molecolare:685.89 g/molRef: 4Z-P-470001
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaPepstatin A
CAS:Formula:C34H63N5O9Purezza:≥ 98.0%Colore e forma:White to off-white powderPeso molecolare:685.90Pepstatin A
CAS:Pepstatin A (isovaleryl-pepstatin), a low molecular weight inhibitor of acid proteases, e.g. pepsin, renin, cathepsin D, and plasmepsin II. For the Plasmodium falciparum aspartyl protease plasmepsin II, Hill et al determined an IC₅₀ of 0.1 nM.Formula:C34H63N5O9Purezza:> 99%Colore e forma:White PowderPeso molecolare:685.9Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Formula:C34H63N5O9Purezza:96.74% - 99.94%Colore e forma:SolidPeso molecolare:685.89L-Alaninamide,N-(3-methyl-1-oxobutyl)-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]-
CAS:Formula:C34H63N5O9Purezza:98%Colore e forma:SolidPeso molecolare:685.8921Ref: IN-DA00I50B
1gPrezzo su richiesta5mg89,00€10mg128,00€25mg152,00€50mg184,00€100mg320,00€250mgPrezzo su richiestaPepstatin A (Purity Higher than 90% by HPLC)
CAS:Pepstatin A is a natural product that inhibits the activity of proteases, particularly chymotrypsin and trypsin. It binds to the active site of these enzymes, blocking access to their substrate. Pepstatin A has been shown to have synergistic effects with other drugs in vitro, such as dapsone and clindamycin. Pepstatin A has inhibitory properties against infectious diseases, including HIV-1 and HIV-2, influenza virus type A (H1N1), herpes simplex virus type 1 (HSV-1), human papilloma virus type 18 (HPV-18), hepatitis C virus (HCV) types 1a and 1b, as well as dengue fever virus. Pepstatin A is also effective in inhibiting polymerase chain reaction amplification of mitochondrial DNA from patients with mitochondrial disorders. The biological sample for this research was obtained from calf thymus tissue. The natural compound pepstatin A hasFormula:C34H63N5O9Purezza:Higher Than 90% By Hplc)Peso molecolare:685.89 g/molPepstatin A
CAS:Pepstatin A was originally purified from Actinomycetes species. The peptide is unusual in containing the amino acid statine (4-amino-hydroxy-6-methylheptanoic acid also known as AMHA). Pepstatin A competitively binds with acid proteases in a highly selective reversible manner to inhibit protease activity. Pepstatin A is ineffective on thiol, neutral and serine proteases. The functions of proteases have been investigated by the application of pepstatin A such as renin, pepsin, bovine chymosin and retroviral proteases from HIV. Characterisation of HIV protease using pepstatin A has been vital in development of HIV treatment to block viral replication. Pepstatin A is also a reagent to disrupt autophagy- this helps characterise the function of proteosome degradation in research such as during influenza A replication and improving drug delivery of therapeutic cancer treatments.Peso molecolare:685.89 g/molPepstatin A
CAS:Pepstatin AFormula:C34H63N5O9Purezza:By hplc: 98.2% (220 nm) (Typical Value in Batch COA)Colore e forma: white to off white powderPeso molecolare:685.89g/molPepstatin A
CAS:Please enquire for more information about Pepstatin A including the price, delivery time and more detailed product information at the technical inquiry form on this pageFormula:C34H63N5O9Purezza:Min. 95%Peso molecolare:685.89 g/mol
