CAS 29767-20-2: Teniposide
Descrizione:
Teniposide, con il numero CAS 29767-20-2, è un derivato semisintetico della podofilotossina, utilizzato principalmente come agente antineoplastico nella terapia del cancro. Funziona inibendo la topoisomerasi II, un enzima cruciale per la replicazione e riparazione del DNA, inducendo così danni al DNA e apoptosi nelle cellule cancerose a rapida divisione. Teniposide viene tipicamente somministrato per via endovenosa ed è indicato per il trattamento di varie malignità, inclusi alcuni tipi di leucemia e tumori solidi. Il composto è caratterizzato dalla sua complessa struttura chimica, che include un gruppo fenolico e un legame etereo, contribuendo alla sua attività biologica. È generalmente solubile in solventi organici, ma ha una solubilità limitata in acqua. Gli effetti collaterali possono includere mielosoppressione, disturbi gastrointestinali e reazioni di ipersensibilità. A causa dei suoi potenti effetti e della potenziale tossicità, Teniposide è solitamente prescritto sotto stretta supervisione medica, con attento monitoraggio della risposta del paziente e degli effetti collaterali durante il trattamento.
Formula:C32H32O13S
InChI:InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1
InChI key:InChIKey=NRUKOCRGYNPUPR-QBPJDGROSA-N
SMILES:O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@@H](OC5)C6=CC=CS6)[H])[H])[C@]2(CO1)[H])=CC7=C(C3)OCO7)C8=CC(OC)=C(O)C(OC)=C8)[H]
Sinonimi:- (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- EPT
- Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-2-thenylidene-β-D-glucopyranoside)
- Epipodophyllotoxin, 4′-demethyl-, 9-(4,6-O-2-thenylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-, [5R-[5α,5aβ,8aα,9β(R*)]]-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-
- Nsc 122819
- Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
- S 122819
- Teniposid
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11 prodotti.
Teniposide
CAS:Type II topoisomerase inhibitorFormula:C32H32O13SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:656.65 g/molTeniposide
CAS:Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II andFormula:C32H32O13SPurezza:97.70% - 99.45%Colore e forma:White Or Off-White Crystalline PowderPeso molecolare:656.65Teniposide - Bio-X ™
CAS:Teniposide is a cytotoxic drug that is used in the treatment of refractory childhood acute lymphoblastic leukemia. It has antitumour activity. It is a type II topoisomerase inhibitor. This drug inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. Teniposide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C32H32O13SPurezza:Min. 95%Colore e forma:PowderPeso molecolare:656.65 g/molRef: 4Z-T-521
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaTeniposide
CAS:Formula:C32H32O13SPurezza:>98.0%(HPLC)Colore e forma:White to Almost white powder to crystalinePeso molecolare:656.66Teniposide
CAS:Formula:C32H32O13SPurezza:≥ 98.0%Colore e forma:White to off-white powderPeso molecolare:656.65Teniposide
CAS:Prodotto controllatoStability Hygroscopic Applications A semi-synthetic derivative of Podophyllotoxin. Antineoplastic. References Stahlen, H., Eur. J. Cancer, 6, 303 (1970), Hacker, M., et al.: Cancer Res., 37, 3287 (1977), Clark, P.I., et al.: Clin. Pharmacokinet., 12, 223 (1987),Formula:C32H32O13SColore e forma:NeatPeso molecolare:656.655-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
CAS:Formula:C32H32O13SPurezza:98%Colore e forma:SolidPeso molecolare:656.6537(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-DihydrOxy-2-(Thiophen-2-yl)Hexahydropyrano[3,2-d][1,3]Dioxin-6-yl)Oxy)-5-(4-hydrOxy-3,5-dimethOxyphenyl)-5,5a,8a,9-Tetrahydrofuro[3,4:6,7]Naphtho[2,3-d][1
CAS:(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-DihydrOxy-2-(Thiophen-2-yl)Hexahydropyrano[3,2-d][1,3]Dioxin-6-yl)Oxy)-5-(4-hydrOxy-3,5-dimethOxyphenyl)-5,5a,8a,9-Tetrahydrofuro[3,4:6,7]Naphtho[2,3-d][1Purezza:98%Peso molecolare:656.65g/molTeniposide (PLANNED TO BE DISCONTINUED)
CAS:Other glycosides, natural or reproduced by synthesis, aFormula:C32H32O13SColore e forma:PowderPeso molecolare:656.15636
![5-[[(6R)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00I5IB.jpg&w=3840&q=75)
![(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-DihydrOxy-2-(Thiophen-2-yl)Hexahydropyrano[3,2-d][1,…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1026151.jpg&w=3840&q=75)
