CAS 33419-42-0: Etoposide
Descrizione:
Etoposide è un agente chemioterapico utilizzato principalmente nel trattamento di vari tipi di cancro, incluso il cancro testicolare e il cancro polmonare a piccole cellule. È classificato come un inibitore della topoisomerasi II, il che significa che interferisce con l'enzima responsabile della replicazione e riparazione del DNA, portando infine alla morte delle cellule tumorali. Etoposide viene tipicamente somministrato per via endovenosa o orale ed è noto per la sua efficacia in combinazione con altri farmaci chemioterapici. Il composto ha una formula molecolare di C21H22O8 e un peso molecolare di circa 366,39 g/mol. Etoposide è caratterizzato dalla sua capacità di indurre apoptosi nelle cellule tumorali, rendendolo uno strumento prezioso in oncologia. Tuttavia, può anche causare effetti collaterali, tra cui mielosoppressione, disturbi gastrointestinali e un aumento del rischio di malignità secondarie. A causa del suo meccanismo d'azione, un attento monitoraggio e gestione del dosaggio sono essenziali per minimizzare la tossicità massimizzando l'efficacia terapeutica. In generale, Etoposide rimane un agente importante nell'arsenale contro alcune malignità.
Formula:C29H32O13
InChI:InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
InChI key:InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N
SMILES:O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@H](C)OC5)[H])[H])[C@]2(CO1)[H])=CC6=C(C3)OCO6)C7=CC(OC)=C(O)C(OC)=C7)[H]
Sinonimi:- (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-alpha-L-gulopyranoside
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-mannopyranoside
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-alpha-L-gulopyranoside
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-beta-D-mannopyranoside
- (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
- 4'-Demethyl-1-O-[4,6-O-(ethylidene)-β-D-glucopyranosyl]epipodophyllotoxin
- 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)
- 4'-Demethylepipodophyllotoxin ethylidene-β-D-glucoside
- 4'-Demethylepipodophyllotoxin-(4,6-O-(R)-Ethylidene-Beta-D-Glucopyranoside)
- 4-Demethylepipodophyllotoxin-Beta-D-Ethylideneglucoside
- Vedi altri sinonimi
Ordinare per
ETOPOSIDE CRS
CAS:ETOPOSIDE CRSFormula:C29H32O13Colore e forma:Crystalline Powder. White. Powder.Peso molecolare:588.5566Etoposide for system suitability CRS
CAS:Etoposide for system suitability CRSFormula:C29H32O13Peso molecolare:588.5566Etoposide
CAS:Formula:C29H32O13Purezza:(HPLC) ≥ 98.0%Colore e forma:White or almost white crystalline powderPeso molecolare:588.56Etoposide
CAS:EtoposideFormula:C29H32O13Purezza:96.2%Colore e forma:Off-WhitePeso molecolare:588.18429Ref: 4Z-E-592
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaEtoposide, USP grade
CAS:Formula:C29H32O13Purezza:(anhydrous basis) 95.0 - 105.0 %Colore e forma:White or almost white crystalline powderPeso molecolare:588.56(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
CAS:Formula:C29H32O13Purezza:98%Colore e forma:SolidPeso molecolare:588.5566Etoposide
CAS:Etoposide is a chemotherapy medication used for the treatments of a number of types of cancer. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA, it induces apoptosis in MCF-7 breast cancer cells.Formula:C29H32O13Purezza:95%~99%Peso molecolare:588.562Etoposide
CAS:EtoposideFormula:C29H32O13Purezza:By hplc: 99.51% by area. (Typical Value in Batch COA)Colore e forma: pale yellow solidPeso molecolare:588.56g/molEtoposide - Bio-X ™
CAS:Etoposide is a cytotoxic drug used in cancer chemotherapy. It inhibits DNA replication through inhibition of DNA topoisomerase II, thus catalysing cell cycle arrest and apoptosis. Etoposide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C29H32O13Purezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:588.56 g/molEtoposide-d4
CAS:Prodotto controllatoEtoposide is a cytotoxic drug used in cancer chemotherapy. It inhibits DNA replication through inhibition of DNA topoisomerase II, thus catalysing cell cycle arrest and apoptosis. This compoud, Etoposide-d4, is a deuterated form of the drug.Formula:C29H32O13Purezza:Min. 95%Etoposide
CAS:Formula:C29H32O13Purezza:>98.0%(HPLC)Colore e forma:White to Almost white powder to crystalPeso molecolare:588.56Etoposide
CAS:Etoposide is used as a inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53-/-) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C29H32O13Colore e forma:Powder or crystals or crystalline powderPeso molecolare:588.56
![(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA003A2V.jpg&w=3840&q=75)
