CAS: 33784-05-3

7b-Spironolactone is an antiandrogenic drug that is used in the treatment of congestive heart failure, ascites and edema associated with cirrhosis, and high blood pressure. It has a prognostic value in patients with liver cirrhosis and can be used to predict the risk of death. Spironolactone is a member of a class of drugs known as potassium-sparing diuretics because it does not cause the loss of potassium from the body. It is also used as a predictor for hepatic dysfunction, which can be caused by spironolactone. 7b-Spironolactone has been shown to reduce the risk of death in patients with liver cirrhosis who have been assigned to placebo groups.

Impurity Spironolactone EP Impurity E Applications 7β-Spironolactone (Spironolactone EP Impurity E) is the 7β-isomer of Spironolactone (S683000). It binds effectively to human plasma proteins. References Chien, Y.W. et al.: J. Pharmac. Sci., 65, 1337 (1976);