CAS: 353262-04-1

4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one is a novel compound that inhibits the activation of microglia and reduces the Ca2+ concentration in activated microglia. It also has a safety profile and does not affect blood pressure or cause autoimmune diseases. Functional assays show that 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one inhibits the production of inflammatory cytokines such as IL-6 and TNFα.

NS6180 is a potent and selective KCa3.1 channel inhibitor(IC50= 9 nM). It prevents T-cell activation and inflammation.

4-[[3-(Trifluoromethyl)phenyl]Methyl]-2H-1,4-Benzothiazin-3(4H)-One

NS6180