CAS: 457639-26-8

2,5-dimethyl Celecoxib, a derivative targeting mPGES-1, inhibits PGE2 synthesis in inflammation.

Applications A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib. References Deckmann, K. et al.: Biochem. Pharmacol., 80, 1365 (2010); Virrey, J.J. et al.: Mol. Cancer. Therap., 9, 631 (2010); Chen, S. et al.: Leukemia Res., 34, 250 (2010);

2,5-dimethyl Celecoxib

2,5-Dimethyl celecoxib is a potent inhibitor of the enzyme cyclooxygenase-2 (COX-2). It also inhibits autophagy, which is an intracellular process that degrades cellular components. 2,5-Dimethyl celecoxib has been shown to potently inhibit the production of PGE2 in mice with colon cancer and to induce apoptosis in human carcinoma cell lines by inhibiting the expression of survivin and MCL-1 proteins.