CAS 50-63-5: (±)-Dihidrogenofosfato di clorochina
Descrizione:
(±)-Dihidrogenofosfato di clorochina è un composto sintetico conosciuto principalmente per il suo utilizzo come agente antimalarico. Appartiene alla classe delle 4-aminochinoline ed è caratterizzato dalla sua capacità di interferire con la crescita del parassita della malaria inibendo la polimerizzazione dell'eme, fondamentale per la sopravvivenza del parassita. Il composto presenta una natura chirale, con due enantiomeri, che possono influenzare la sua attività farmacologica e gli effetti collaterali. Oltre alle sue proprietà antimalariche, la clorochina è stata studiata per i potenziali effetti antivirali e come agente immunomodulatore in varie malattie autoimmuni. La forma di sale di difosfato ne migliora la solubilità e stabilità in soluzioni acquose, rendendola adatta per formulazioni farmaceutiche. La clorochina viene tipicamente somministrata per via orale e ha una emivita relativamente lunga, consentendo una somministrazione una volta al giorno in alcuni casi. Tuttavia, il suo utilizzo è stato associato a effetti collaterali, tra cui disturbi gastrointestinali e potenziale tossicità retinica con uso a lungo termine. Come per qualsiasi farmaco, è essenziale considerare attentamente i suoi benefici e rischi in contesti clinici.
Formula:C18H26ClN3·2H3O4P
InChI:InChI=1S/C18H26ClN3.H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);(H3,1,2,3,4)
InChI key:InChIKey=AEUAEICGCMSYCQ-UHFFFAOYSA-N
SMILES:P(=O)(O)(O)O.N(C(CCCN(CC)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2
Sinonimi:- 1,4-Pentanediamine, N<sup>4</sup>-(7-chloro-4-quinolinyl)-N<sup>1</sup>,N<sup>1</sup>-diethyl-, phosphate (1:2)
- 3377 Rp
- 3377Rp
- 7-Chlor-4-(4-diaethylamino)-1-methylbutylamino)-chinolindiphosphat
- 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline phosphate (1:2)
- 7-Chloro-4-[(4′-diethylamino-1-methylbutyl)amino]quinoline diphosphate
- Ai3-14952
- Alermine
- Alexoquine
- Aralen diphosphate
- Aralen phosphate
- Vedi altri sinonimi
Ordinare per
Chloroquine phosphate for peak identification CRS
CAS:Chloroquine phosphate for peak identification CRSChloroquine diphosphate salt, 98%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C18H32ClN3O8P2Purezza:98%Colore e forma:White to beige, PowderPeso molecolare:515.86Ref: ST-EA-CP-C69001
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaChloroquine diphosphate salt
CAS:Formula:C18H26ClN3·2H3PO4Purezza:(Titration) 98.0 - 102.0 % (dried basis)Colore e forma:White or almost white crystalline powderPeso molecolare:515.87Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate (6CI)
CAS:Formula:C18H30ClN3O7P2Purezza:98%Colore e forma:SolidPeso molecolare:497.8472Chloroquine phosphate
CAS:Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is used as an autophagy inhibitor. Chloroquine also is an inhibitor of TLRs.Formula:C18H26CLN3·2(H3PO4)Purezza:99.64% - ≥95%Colore e forma:White To Slightly Yellow Crystalline Powder White SolidPeso molecolare:515.87Chloroquine phosphate
CAS:Chloroquine phosphateFormula:C18H26ClN3H3PO4Purezza:98.4%Colore e forma:Light BrownPeso molecolare:417.15842Chloroquine-d5 Diphosphate
CAS:Formula:C18H21D5ClN3·2H3O4PColore e forma:White To Off-White SolidPeso molecolare:324.91 2*97.99Ref: 4Z-C-922
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaChloroquine Diphosphate
CAS:Formula:C18H26ClN3·2H3O4PColore e forma:White To Off-White SolidPeso molecolare:319.88 2*97.99Ref: 4Z-C-921
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaChloroquine Phosphate
CAS:Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fusedFormula:C18H26ClN3·2H3PO4Colore e forma:Yellow PowderPeso molecolare:515.13532Chloroquine-d4 Phosphate Salt
CAS:Prodotto controllatoApplications Labelled anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product. References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),Formula:C18H22D4ClN3•xH3PO4Colore e forma:Yellow SolidPeso molecolare:323.9098Chloroquine diphosphate
CAS:Prodotto controllatoChloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic protozoan from the Plasmodium genus. Chloroquine i a schizonticidal agent and is a widely prescribed antimalarial compound. The antiviral activity of chloroquine in vitro has been reported in 1960’s and recent publications have brought attention to its possible benefits in the treatment of COVID-19 patients, infected with the newly emerged coronavirus (SARS-CoV-2). Current evidence shows that chloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the S-glycoprotein.Formula:C18H32ClN3O8P2Colore e forma:White Off-White PowderPeso molecolare:515.86 g/molChloroquine diphosphate salt, 98%
CAS:Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 μM.This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C18H32ClN3O8P2Purezza:98%Colore e forma:Powder or crystals or crystalline powder, White to off-whitePeso molecolare:515.86Chloroquine Diphosphate Salt
CAS:Stability Hygroscopic Applications Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labelling of MRP by quinoline-based photoactive drug IAAQ. It is a COVID19-related research product. References Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983), Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998), Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999),Formula:C18H26ClN3·2H3O4PColore e forma:Light BrownPeso molecolare:515.86
![Quinoline, 7-chloro-4-[(4-diethylamino-1-methylbutyl)amino]-, diphosphate (6CI)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA0034LP.jpg&w=3840&q=75)
