CAS 65710-07-8: Solfato di apramicina
Descrizione:
Solfato di apramicina è un antibiotico aminoglicosidico derivato dal batterio *Micromonospora purpurea*. È utilizzato principalmente in medicina veterinaria per il trattamento di infezioni batteriche nel bestiame e negli uccelli. Il composto mostra un'attività antibatterica ad ampio spettro, in particolare contro i batteri Gram-negativi, ed è efficace nel trattamento di infezioni causate da alcuni ceppi di *Escherichia coli* e *Salmonella*. L'apramicina funziona inibendo la sintesi proteica batterica, legandosi alla subunità ribosomiale 30S, il che interrompe il processo di traduzione. La forma solfato ne migliora la solubilità e stabilità in soluzioni acquose, rendendola adatta per iniezione o somministrazione orale. In termini di sicurezza, l'apramicina è generalmente ben tollerata negli animali, ma è necessario prestare attenzione per evitare potenziali nefrotossicità e ototossicità, effetti collaterali comuni associati agli aminoglicosidi. Il suo utilizzo negli animali da produzione alimentare è soggetto a regolamentazioni per prevenire residui di antibiotici nei prodotti a base di carne. In generale, Solfato di apramicina è uno strumento prezioso in medicina veterinaria, contribuendo alla gestione delle malattie infettive nel bestiame.
Formula:C21H41N5O11·xH2O4S
InChI:InChI=1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1
InChI key:InChIKey=WGLYHYWDYPSNPF-RQFIXDHTSA-N
SMILES:O[C@H]1[C@@]2([C@@](O[C@H](O[C@H]3O[C@H](CO)[C@@H](N)[C@H](O)[C@H]3O)[C@H]1NC)(C[C@@H](N)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](N)C[C@@H]4N)O2)[H])[H].S(=O)(=O)(O)O
Sinonimi:- (2R,3R,4S,5S,6S)-5-Amino-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol sulfate (1:1) (non-preferred name)
- (2R,3R,4S,5S,6S)-5-amino-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol sulfate (salt) (non-preferred name)
- (2R,3S,4R,4aR,6S,7R,8aS)-7-Amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl 4-amino-4-deoxy-alpha-D-glucopyranoside sulfate (1:1)
- (2S,3S,4R,5S,6R)-2-[[(2R,3R,4aR,6S,7R,8S,8aR)-3-amino-2-[(1S,2S,3R,4R,6R)-4,6-diamino-2,3-dihydroxy-cyclohexoxy]-8-hydroxy-7-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-6-yl]oxy]-5-amino-6-(hydroxymethyl)tetrahydropyran-3,4-diol
- 265-890-7
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-4-amino-4-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-<smallcap>D</smallcap>-glycero-α-<smallcap>D</span>-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (1:?)
- <span class="text-smallcaps">D</smallcap>-Streptamine, O-4-amino-4-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-<smallcap>D</smallcap>-glycero-α-<smallcap>D</span>-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (salt)
- Ai3-29795
- Apramycin Sulfate
- Apramycin, sulfate (2:5)
- D-Streptamine, O-4-amino-4-deoxy-alpha-D-glucopyranosyl-(1-8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octadialdo-1,5:8,4-dipyranosyl-(1-4)-2-deoxy-, sulfate (salt)
- Vedi altri sinonimi
Ordinare per
11 prodotti.
Apramycin sulfate salt
CAS:Formula:C21H41N5O11·xH2SO4Purezza:Apramycin: ≥ 550μg/mg (anhydrous basis)Colore e forma:Yellow to dark yellow powderPeso molecolare:539.58 (free base)Apramycin sulfate, 96%
CAS:Potent inhibitor of protein synthesis in bacteria.Apramycin sulfate is used as a potent inhibitor of protein synthesis in bacteria. It acts as an antibacterial agent. It is a useful biochemical for antibiotic and antibacterial research to study antibiotic resistance through protein synthesis inhibition by blocking translocation. It is also essential for clinic in vitro tests known as antimicrobial susceptibility tests to determine their efficacy against certain bacterial species. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C21H43N5O15SPurezza:96%Colore e forma:Powder, Pale yellow to yellowPeso molecolare:637.66Apramycin sulphate
CAS:Apramycin sulphateFormula:C21H41N5O11·H2SO4Colore e forma: light brown powderPeso molecolare:637.66g/molApramycin sulfate
CAS:Apramycin sulfate is a semisynthetic antibiotic that inhibits the growth of Gram-negative bacteria. It is a sulfonamide and has been used in clinical isolates to treat bacterial infections. Apramycin sulfate inhibits the biosynthesis of folic acid, which is important for DNA synthesis and cell division. It also inhibits the production of RNA by binding to ribosomes and inhibiting protein synthesis. Apramycin has been shown to have anticancer properties as well, with studies showing that it can inhibit tumor growth in vitro and in vivo.Formula:C21H41N5O11·H2SO4Purezza:Min. 550 Usp U/MgColore e forma:Brown Slightly Yellow Yellow PowderPeso molecolare:637.66 g/molRef: ST-EA-CP-A105002
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaApramycin Sulfate
CAS:Prodotto controllatoApplications Broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius. Antibacterial. References Thompson, R.Q., et al.: Antimicrob. Agents Chemother., 332 (1967), Ryden, R., et al.: J. Antimicrob. Chemother., 3, 609 (1977), Smith, P., et al.: Clin. Therap., 23, 1231 (2001),Formula:C21H41N5O11·H2O4SColore e forma:NeatPeso molecolare:637.66Apramycin sulfate
CAS:Prodotto controllatoFormula:C21H41N5O11·H2O4SColore e forma:NeatPeso molecolare:637.66Apramycin sulfate
CAS:Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C21H43N5O15SColore e forma:Pale yellow to yellow-brown powder, PowderPeso molecolare:637.66Apramycin Sulfate
CAS:Formula:C21H41N5O11·xH2SO4Purezza:>90.0%(HPLC)Colore e forma:Light yellow to Yellow powder to crystalApramycin sulfate
CAS:Apramycin sulfate (Nebramycin II) is an aminoglycoside antibiotic.Formula:C21H43N5O15SPurezza:99.14% - 99.96%Colore e forma:PowderPeso molecolare:637.66
