CAS 80-08-0: Dapsone
Descrizione:
Dapsone, con il numero CAS 80-08-0, è un antibiotico sulfonamide aromatico utilizzato principalmente nel trattamento della lebbra e di alcuni tipi di dermatite, come la dermatite erpetiforme. È una polvere cristallina bianca a bianco sporco che è leggermente solubile in acqua e più solubile in solventi organici come etanolo e acetone. Dapsone agisce inibendo la sintesi del folato batterico, esercitando così i suoi effetti antimicrobici. La sua formula chimica è C12H12N2O2S e ha un peso molecolare di circa 240,3 g/mol. Dapsone è noto per le sue proprietà anti-infiammatorie, rendendolo efficace nel trattamento di condizioni cutanee autoimmuni. Sebbene generalmente ben tollerato, può causare effetti collaterali come anemia emolitica, specialmente in individui con carenza di glucosio-6-fosfato deidrogenasi. Si raccomanda il monitoraggio dei parametri ematici durante il trattamento. Dapsone è spesso usato in combinazione con altri farmaci per aumentare l'efficacia terapeutica e ridurre il rischio di resistenza.
Formula:C12H12N2O2S
InChI:InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
InChI key:InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N
SMILES:S(=O)(=O)(C1=CC=C(N)C=C1)C2=CC=C(N)C=C2
Sinonimi:- 1,1'-Sulfonylbis[4-aminobenzene]
- 1358F
- 4,4'-Dapsone
- 4,4'-Dds
- 4,4'-Diamino Diphenyl Sulfone
- 4,4'-Diamino Diphenyl Sulphone
- 4,4'-Diaminodiphenylsulfon
- 4,4'-Diaminodiphenylsulfone
- 4,4'-Sulfonylbisaniline
- 4,4'-Sulfonylbisbenzamine
- 4,4'-Sulfonyldiphenylamine
- Vedi altri sinonimi
Ordinare per
Dapsone
CAS:Other aromatic organo-sulfur compounds (excluding pesticides)Formula:C12H12N2O2SColore e forma:White Off-White Light Yellow Crystalline PowderPeso molecolare:248.06195Ref: 4Z-D-0133
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaDapsone
CAS:Prodotto controllatoApplications An antibacterial used in the treatment of dermatitis herpetiformis. References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),Formula:C12H12N2O2SColore e forma:NeatPeso molecolare:248.30Di-(4-(4'-Aminidiphenylsulphone))amine
CAS:Prodotto controllatoFormula:C24H21N3O4S2Colore e forma:NeatPeso molecolare:479.571Dapsone
CAS:Dapsone is a nonsteroidal anti-inflammatory drug that is used to treat various types of infectious diseases and skin disorders. It acts by blocking the synthesis of dihydrofolic acid, which leads to inhibition of bacterial growth. Dapsone inhibits the activity of monoethyl ether reductase (NADH) in human polymorphonuclear leukocytes, which slows the production of hydrogen peroxide and prevents oxidative damage to cellular components. It has been shown to be effective against both erythema multiforme and chronic dermatitis herpetiformis with minimal side effects. The use of dapsone may be helpful in diagnosis as it can inhibit polymerase chain reactions that are specific for squamous cells. There are also reports that dapsone may affect intestinal motility and cause bowel disease.Formula:C12H12N2O2SPurezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:248.3 g/mol4,4'-Diaminodiphenyl sulfone, 98%
CAS:It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. It is a second-line medication for the treatment and prevention of Pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function. Additionally, it has been used for acne as well as other skin conditions. Moreover it is employed as an anti-inflammatory drug, anti-infective drug, a leprostatic drug and an antimalarial drug. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C12H12N2O2SPurezza:98%Colore e forma:White to pale cream, PowderPeso molecolare:248.30Dapsone
CAS:Formula:C12H12N2O2SPurezza:(Titration) 98.0 - 102.0 %Colore e forma:White to off-white crystalline powderPeso molecolare:248.304-Aminophenyl sulfone, 97%
CAS:This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.Formula:C12H12N2O2SPurezza:97%Colore e forma:Crystalline powder, White to beigePeso molecolare:248.304-[(4-aminobenzene)sulfonyl]aniline
CAS:Purezza:97.0%Colore e forma:SolidPeso molecolare:248.30000305175784,4'-Sulfonyldianiline
CAS:Formula:C12H12N2O2SPurezza:98%Colore e forma:SolidPeso molecolare:248.30088Dapsone
CAS:Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.Formula:C12H12N2O2SPurezza:99.84%Colore e forma:White To Creamy Solid CrystallinePeso molecolare:248.3Bis(4-aminophenyl) Sulfone
CAS:Bis(4-aminophenyl) SulfoneFormula:C12H12N2O2SPurezza:97%Colore e forma: off-white solidPeso molecolare:248.30g/mol
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