CAS: 96568-02-4

2,6-Dichloro-5-fluoronicotinoyl chloride is a reagent that is used for the preparation of heterocycles. It can be prepared by heating phosphorus oxychloride with 2,6-dichloro-5-fluorobenzonitrile in the presence of sodium hydride and hydrolyzing the reaction mixture with water. This reagent reacts with alcohols to give phosphoric esters, which are useful as intermediates in organic synthesis. The major products from this reaction are chlorinated derivatives of the original alcohol. Hydrolysis yields an acid ester, which can be cyclized to produce a heterocyclic compound.

2,6-Dichloro-5-fluoronicotinoyl chloride