Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora
- CDK
- Arresto del ciclo cellulare
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosi
- HSP
- Integrina
- Chinesina
- KSP
- LIM chinasi
- Microtubulo associato
- PKC
- PLK
- Rho
- ROCK
- Wee1
Mostrare 11 più sottocategorie
Prodotti di "Ciclo cellulare/Checkpoint"
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Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formula:C27H20ClFN4O4Purezza:100% - 99.82%Colore e forma:SolidPeso molecolare:518.92Ref: TM-T2241
5mg55,00€10mg96,00€25mg155,00€50mg226,00€100mg354,00€200mg454,00€500mg743,00€1mL*10mM (DMSO)63,00€4μ8C
CAS:4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Formula:C11H8O4Purezza:97.48% - 98.45%Colore e forma:SolidPeso molecolare:204.18CDK-IN-15
CAS:CDK-IN-15 (Compound 456) is an effective inhibitor of Cyclin A, exhibiting an IC50 value of 0.14 μM.Formula:C45H63Cl2F4N7O8Colore e forma:SolidPeso molecolare:976.92GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Formula:C16H21BrClN5OPurezza:97.85%Colore e forma:SolidPeso molecolare:414.73Ref: TM-T27407
1mg46,00€2mg58,00€5mg85,00€10mg108,00€25mg187,00€50mg269,00€100mg376,00€200mg548,00€1mL*10mM (DMSO)87,00€CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Formula:C23H25ClFN5Purezza:99%Colore e forma:SolidPeso molecolare:425.93Ref: TM-T14918
1mg88,00€5mg187,00€10mg281,00€25mg487,00€50mg705,00€100mg998,00€1mL*10mM (DMSO)207,00€Emzadirib
CAS:Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.Formula:C27H40N4O6S2Purezza:99.79%Colore e forma:SolidPeso molecolare:580.7610074-A4
CAS:10074-A4 is a c-Myc binding compound that associates with c-Myc370-409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features fromFormula:C18H14Cl2N2O3SPurezza:98.01%Colore e forma:SolidPeso molecolare:409.29Ref: TM-T9628
1mg71,00€5mg135,00€10mg197,00€25mg335,00€50mg480,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)156,00€BI-1950
CAS:BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Formula:C32H26Cl2FN7O3Purezza:98%Colore e forma:SolidPeso molecolare:646.5MYCi975
CAS:MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.Formula:C25H16Cl2F6N2O2Purezza:99.3% - 99.58%Colore e forma:SolidPeso molecolare:561.3AG-024322
CAS:AG-024322 is a pan-CDK inhibitor with antitumor activity, induces apoptosis, and can be used in the study of metabolic diseases.Formula:C23H20F2N6Purezza:98.53%Colore e forma:SolidPeso molecolare:418.44TG003
CAS:TG003 is a Clk1/Sty inhibitor that inhibits Clk1 and Clk4, suppresses cancer cell growth, and induces apoptosis.Formula:C13H15NO2SPurezza:99.46%Colore e forma:SolidPeso molecolare:249.33Ref: TM-T60367
1mg50,00€5mg97,00€10mg159,00€25mg281,00€50mg465,00€100mg558,00€200mg810,00€1mL*10mM (DMSO)170,00€PHA-680632
CAS:PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Formula:C28H35N7O2Purezza:98.20%Colore e forma:SolidPeso molecolare:501.62T4 UvsX Recombinase
T4 UvsX Recombinase initiates DNA replication on double-stranded templates by catalyzing synapsis with a homologous primer single strand.Purezza:98%Colore e forma:Odour SoliddGTP
CAS:dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, andFormula:C10H16N5O13P3Purezza:99.9%Colore e forma:SolidPeso molecolare:507.18Avotaciclib hydrochloride
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, includingFormula:C13H12ClN7OPurezza:98%Colore e forma:SolidPeso molecolare:317.73RI-2
CAS:RI-2, a potent RAD51 inhibitor, has a 44.17 μM IC50 and selectively blocks human HR repair.Formula:C21H18Cl2N2O4Purezza:98.85% - 99.86%Colore e forma:SolidPeso molecolare:433.28Ref: TM-T2628
1mg73,00€2mg97,00€5mg160,00€10mg281,00€25mg435,00€50mg640,00€100mg910,00€1mL*10mM (DMSO)170,00€CDK9-IN-29
CAS:CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.Formula:C29H33F2N5O4Purezza:98%Colore e forma:SolidPeso molecolare:553.6PD-1/PD-L1-IN-50
Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.Colore e forma:Odour SolidBMS-8
CAS:BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.Formula:C27H28BrNO3Purezza:99.06%Colore e forma:SolidPeso molecolare:494.42Ref: TM-T26859
1mg39,00€5mg84,00€10mg131,00€25mg269,00€50mg432,00€100mg638,00€200mg909,00€1mL*10mM (DMSO)96,00€Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurezza:98% - 99.75%Colore e forma:SolidPeso molecolare:393.49Ref: TM-T1825
1mg38,00€2mg49,00€5mg70,00€10mg88,00€25mg164,00€50mg224,00€100mg393,00€1mL*10mM (DMSO)70,00€
