Ciclo cellulare/Checkpoint
Gli inibitori del ciclo cellulare/dei checkpoint sono composti che interrompono la normale progressione del ciclo cellulare, in particolare nei principali punti di controllo regolatori. Questi inibitori sono fondamentali per studiare la divisione cellulare, comprendere la proliferazione delle cellule cancerose e sviluppare terapie antitumorali. Mirando a fasi specifiche del ciclo cellulare, questi inibitori possono indurre l'arresto del ciclo cellulare, portando all'apoptosi o alla senescenza nelle cellule che si dividono rapidamente. Presso CymitQuimica, offriamo una vasta gamma di inibitori di alta qualità del ciclo cellulare/dei checkpoint per supportare le tue ricerche in biologia del cancro, biologia cellulare e sviluppo di farmaci.
Sottocategorie di "Ciclo cellulare/Checkpoint"
- Chinasi aurora
- CDK
- Arresto del ciclo cellulare
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosi
- HSP
- Integrina
- Chinesina
- KSP
- LIM chinasi
- Microtubulo associato
- PKC
- PLK
- Rho
- ROCK
- Wee1
Mostrare 11 più sottocategorie
Prodotti di "Ciclo cellulare/Checkpoint"
Ordinare per
CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Formula:C21H22N4OColore e forma:SolidPeso molecolare:346.43Gallium maltolate
CAS:Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor.Formula:C18H15GaO9Purezza:99.67% - 99.75%Colore e forma:SolidPeso molecolare:445.03Pyridostatin TFA
CAS:Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-Formula:C37H35F9N8O11Purezza:97.09% - 99.84%Colore e forma:SolidPeso molecolare:938.71TMX-2039
CAS:TMX-2039 is a pan-CDK inhibitor that targets cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcription CDKs (CDK7 and CDK9), with IC50 values of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5, and 25 nM, respectively. It serves as a ligand for the target protein in PROTAC applications.Formula:C17H20BrFN6O3SColore e forma:SolidPeso molecolare:487.347Stigmatellin
CAS:Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.Formula:C30H42O7Colore e forma:SolidPeso molecolare:514.65MGB-BP-3
CAS:MGB-BP-3 is a synthetic antibiotic with bactericidal activity that inhibits bacterial DNA replication and can be used to study recurrent C. difficile infections.Formula:C36H37N7O4Purezza:97.06% - 98.92%Colore e forma:SolidPeso molecolare:631.72STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Purezza:95% - 95%Colore e forma:Odour Liquid2',3'-Dideoxyuridine
CAS:2',3'-Dideoxyuridine is a purine nucleoside analog with potential antitumor activity.Formula:C9H12N2O4Purezza:99.76%Colore e forma:SolidPeso molecolare:212.2WRN inhibitor 11
CAS:WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Formula:C34H35ClF3N9O5Colore e forma:SolidPeso molecolare:742.15C16Y
CAS:C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Formula:C78H115N17O17Colore e forma:SolidPeso molecolare:1562.85EMD534085
CAS:EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).Formula:C25H31F3N4O2Purezza:98%Colore e forma:SolidPeso molecolare:476.53Ref: TM-TQ0314
1mgPrezzo su richiesta5mgPrezzo su richiesta10mgPrezzo su richiesta500µgPrezzo su richiesta5-Methylcytosine
CAS:5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA.Formula:C5H7N3OPurezza:99.17%Colore e forma:SolidPeso molecolare:125.13SRI-29329
CAS:SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Formula:C20H26ClN7Purezza:99.18%Colore e forma:SolidPeso molecolare:399.92Ref: TM-T8801
1mg92,00€5mg188,00€10mg306,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)215,00€3-AP
CAS:3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).Formula:C7H9N5SPurezza:97.33% - 99.75%Colore e forma:SolidPeso molecolare:195.24Ref: TM-T1982
2mg39,00€5mg57,00€10mg69,00€25mg150,00€50mg264,00€100mg400,00€500mg909,00€1mL*10mM (DMSO)57,00€Human PD-L1 inhibitor V
CAS:Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectivelyFormula:C65H104N20O18SPurezza:98%Colore e forma:SolidPeso molecolare:1485.71T521
CAS:T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.Formula:C17H14FNO5S2Purezza:99.65%Colore e forma:SolidPeso molecolare:395.43AZ5576
CAS:AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].Formula:C21H24FN3O3Purezza:99.88%Colore e forma:SoildPeso molecolare:385.43Ref: TM-T60152
1mg35,00€5mg80,00€10mg113,00€25mg221,00€50mg331,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)87,00€PROTAC CDK9 degrader-11
CAS:PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formula:C39H48Cl2N10O5Colore e forma:SolidPeso molecolare:807.768SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formula:C15H18BrN7Purezza:99.95%Colore e forma:SolidPeso molecolare:376.25Ref: TM-T3700
1mg49,00€2mg70,00€5mg96,00€10mg155,00€25mg264,00€50mg424,00€100mg627,00€1mL*10mM (DMSO)114,00€Senexin C
CAS:Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formula:C28H27N5OPurezza:97.91%Colore e forma:SolidPeso molecolare:449.55
