c-Met/HGFR
Gli inibitori di c-Met/HGFR mirano al Recettore del Fattore di Crescita degli Epatociti (c-Met), una tirosina chinasi coinvolta in processi cellulari come crescita, motilità e morfogenesi. La segnalazione di c-Met è implicata nella progressione del cancro, nella metastasi e nella resistenza alle terapie. L'inibizione di c-Met può interrompere la crescita e la diffusione del tumore, rendendo questi inibitori preziosi nella ricerca sul cancro. Presso CymitQuimica, offriamo inibitori di c-Met/HGFR per supportare la tua ricerca in oncologia, metastasi e terapie oncologiche mirate.
Prodotti di "c-Met/HGFR"
Ordinare per
Tyrosine kinase-IN-6
CAS:Tyrosine kinase-IN-6 is a potent inhibitor of RON splice variants, demonstrating significant anticancer and antineoplastic effects [1].Formula:C37H31F2N5O5SPurezza:98%Colore e forma:SolidPeso molecolare:695.73SGX-523
CAS:SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.Formula:C18H13N7SPurezza:100% - 99.49%Colore e forma:SolidPeso molecolare:359.41Glesatinib
CAS:Glesatinib is an orally active and potent dual inhibitor of MET/SMO.Formula:C31H27F2N5O3S2Purezza:98%Colore e forma:SolidPeso molecolare:619.7Tivantinib
CAS:Tivantinib (ARQ 197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity.Formula:C23H19N3O2Purezza:98% - 99.41%Colore e forma:SolidPeso molecolare:369.42S49076
CAS:S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.Formula:C22H22N4O4SPurezza:95.35% - 97.4%Colore e forma:SolidPeso molecolare:438.5Ref: TM-T3274
1mg47,00€2mg63,00€5mg84,00€10mg96,00€25mg170,00€50mg305,00€100mg558,00€1mL*10mM (DMSO)92,00€DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formula:C41H42FN5O7Purezza:99.28%Colore e forma:SolidPeso molecolare:735.8X-376
CAS:X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase ALK with potential antineoplastic activity.Formula:C25H25Cl2FN6O3Purezza:97.87%Colore e forma:SolidPeso molecolare:547.41Ref: TM-T3550
1mg35,00€2mg50,00€5mg87,00€10mg119,00€25mg258,00€50mg427,00€100mg582,00€1mL*10mM (DMSO)105,00€Amuvatinib
CAS:Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.Formula:C23H21N5O3SPurezza:98.48% - 99.54%Colore e forma:SolidPeso molecolare:447.51KRC-00715
CAS:KRC-00715 is an orally effective inhibitor of c-Met, exhibiting high selectivity with an IC50 of 9.0 nM. This compound specifically inhibits the growth of gastric cancer cell lines with high c-Met expression by inducing G1/S phase block, and reduces the activity of downstream signals, including Akt, Erk, and c-Met itself. In the gastric cancer cell line Hs746T, KRC-00715 demonstrates cytotoxicity with an IC50 of 39 nM and selectively inhibits the proliferation of cell lines that overexpress c-Met. Additionally, KRC-00715 decreases tumor size in Hs746T xenograft mouse models.Formula:C25H25F3N8O3Colore e forma:SolidPeso molecolare:542.51AMG-458
CAS:AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.Formula:C30H29N5O5Purezza:99.77% - 99.91%Colore e forma:SolidPeso molecolare:539.58c-Kit-IN-1
CAS:c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).Formula:C26H21F2N5O3Purezza:98.16% - 98.72%Colore e forma:SolidPeso molecolare:489.47Ref: TM-T4332
1mg46,00€2mg59,00€5mg87,00€10mg144,00€25mg304,00€50mg542,00€100mg778,00€500mg1.605,00€1mL*10mM (DMSO)94,00€c-Met-IN-18
C-Met-IN-18, an ATP-competitive type-III inhibitor, targets both wild-type (WT) and D1228V mutant c-MET with IC50 values of 0.013 µM and 0.20 µM, respectively.Formula:C21H15FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:374.37Umikibart
Umikibart is a humanized IgG4κ antibody targeting HGF, with the corresponding isotype control being HumanIgG4(S228P) kappa, Isotype Control.Colore e forma:Odour Liquidc-Met-IN-26
CAS:c-Met-IN-26 (compound 1-170) is an effective inhibitor of c-Met, exhibiting an IC50 of 1.6 nM.Formula:C24H19F2N9Colore e forma:SolidPeso molecolare:471.46BMS-777607
CAS:BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3.Formula:C25H19ClF2N4O4Purezza:98.16% - 98.30%Colore e forma:SolidPeso molecolare:512.89Ref: TM-T2658
2mg63,00€5mg90,00€10mg142,00€25mg265,00€50mg409,00€100mg727,00€200mg1.091,00€500mg1.636,00€BMS817378
CAS:BMS817378 is a potent and selective inhibitor of MET(IC50 : 1.7 nM).Formula:C24H18ClF2N4O7PPurezza:100%Colore e forma:SolidPeso molecolare:578.85Cabozantinib hydrochloride
CAS:Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6Formula:C28H25ClFN3O5Purezza:99.97%Colore e forma:SolidPeso molecolare:537.96Ref: TM-T5164
1mg44,00€2mg55,00€5mg69,00€10mg97,00€25mg169,00€50mg248,00€100mg349,00€200mg568,00€500mg908,00€c-Met-IN-19
c-Met-IN-19 (Compound 21j) is a potent c-Met inhibitor with an IC50 of 1.99 nM and demonstrates cytotoxic effects on various cancer cell lines, including A549,Formula:C34H37Cl2FN4O7SPurezza:98%Colore e forma:SolidPeso molecolare:735.65Davutamig
CAS:Davutamig (REGN-5093) is a humanized IgG4-kappa, anti-MET monoclonal antibody that binds to two distinct, nonoverlapping epitopes on the MET receptor.Purezza:98%Colore e forma:LiquidPF-04217903 methanesulfonate
CAS:PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).Formula:C20H20N8O4SPurezza:98%Colore e forma:SolidPeso molecolare:468.49
