c-RET
Gli inibitori di c-RET prendono di mira il proto-oncogene RET (Rearranged during Transfection), che codifica una tirosina chinasi recettoriale coinvolta nella crescita, differenziazione e sopravvivenza cellulare. L'attivazione anomala della segnalazione RET può portare a una proliferazione cellulare incontrollata e alla resistenza all'apoptosi, contribuendo allo sviluppo di tumori come il carcinoma midollare della tiroide e il carcinoma polmonare non a piccole cellule. L'inibizione di c-RET può indurre l'apoptosi nelle cellule tumorali ed è un approccio promettente nella terapia oncologica mirata. Presso CymitQuimica, offriamo una varietà di inibitori di c-RET di alta qualità per supportare la tua ricerca in oncologia, trasduzione del segnale e apoptosi.
Prodotti di "c-RET"
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16 prodotti in questa categoria.
RET-IN-23
CAS:RET-IN-23 is an orally available and highly potent RET inhibitor with significant antitumor activity for the study of non-small cell lung cancer.Formula:C28H28FN11Purezza:97.46%Colore e forma:SolidPeso molecolare:537.59DUN73423
CAS:DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.Formula:C19H16N6OColore e forma:SolidPeso molecolare:344.37RET-IN-3
CAS:RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.Formula:C18H21N5O2Purezza:99.52%Colore e forma:SolidPeso molecolare:339.39Ref: TM-T9673
1mg94,00€5mg216,00€10mg344,00€25mg645,00€50mg1.017,00€100mg1.568,00€1mL*10mM (DMSO)240,00€Agerafenib hydrochloride
CAS:Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).Formula:C24H23ClF3N5O5Purezza:98%Colore e forma:SolidPeso molecolare:553.92Enbezotinib
CAS:Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.Formula:C21H21FN6O3Purezza:99.79%Colore e forma:SolidPeso molecolare:424.43Ref: TM-T62285
1mg120,00€5mg283,00€10mg445,00€25mg730,00€50mg998,00€100mg1.311,00€1mL*10mM (DMSO)319,00€Selpercatinib
CAS:"Selpercatinib (LOXO-292) is a RET tyrosine kinase inhibitor with IC50s of 14.0, 24.1, 530.7 nM for different RET mutations."Formula:C29H31N7O3Purezza:100% - 99.89%Colore e forma:SolidPeso molecolare:525.6Ref: TM-T8222
2mg35,00€5mg51,00€10mg88,00€25mg170,00€50mg274,00€100mg505,00€200mg730,00€500mg1.093,00€Pralsetinib
CAS:Pralsetinib (Blu667) (BLU-667) is a highly potent, selective RET inhibitor (IC50s: 0.4, 0.3, 0.4, 0.4, and 0.4 nM for WT RET, RET mutants V804L, V804M, M918TFormula:C27H32FN9O2Purezza:97.88% - 98.1%Colore e forma:SolidPeso molecolare:533.6Ref: TM-TQ0277
1mg43,00€2mg56,00€5mg103,00€10mg145,00€25mg283,00€50mg530,00€100mg745,00€1mL*10mM (DMSO)120,00€BBT594
CAS:BBT594 (NVP-BBT594)(NVP-BBT594) is a potent inhibitor of receptor tyrosine kinase RET,Treatment of cancer.Formula:C28H30F3N7O3Purezza:99.57%Colore e forma:SolidPeso molecolare:569.58BT-13
CAS:BT-13 activates RET receptor without GFLs, fostering sensory neuron neurite growth in vitro.Formula:C23H27F4N3O4SPurezza:99.23%Colore e forma:SolidPeso molecolare:517.54Ref: TM-T10624
1mg43,00€2mg57,00€5mg96,00€10mg134,00€25mg220,00€50mg329,00€100mg470,00€1mL*10mM (DMSO)97,00€Vepafestinib
CAS:Vepafestinib is a RET inhibitor with potential antineoplastic activity[1].Formula:C26H30N6O3Purezza:98.54%Colore e forma:SolidPeso molecolare:474.55trans-Pralsetinib
CAS:trans-Pralsetinib (trans-BLU-667) is an inhibitor of rearranged during transfection (RET).Formula:C27H32FN9O2Purezza:98%Colore e forma:SolidPeso molecolare:533.6Compound TPX-0046
CAS:Compound TPX-0046 is an inhibitor of RET. Compound TPX-0046 can inhibit the RET autophosphorylation. Compound TPX-0046 can be used for the research of cancer.Formula:C21H21FN6O3Purezza:99.85%Colore e forma:SoildPeso molecolare:424.43SPP-86
CAS:SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.Formula:C16H15N5Purezza:98.19%Colore e forma:SolidPeso molecolare:277.32Ref: TM-T16923
1mg48,00€5mg96,00€10mg153,00€25mg298,00€50mg472,00€100mg687,00€500mg1.444,00€1mL*10mM (DMSO)96,00€RET V804M-IN-1
CAS:RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).Formula:C19H16N6OPurezza:97.94% - 99.62%Colore e forma:SolidPeso molecolare:344.37Ref: TM-T8467
1mg38,00€2mg49,00€5mg79,00€10mg96,00€25mg165,00€50mg250,00€100mg354,00€200mg522,00€1mL*10mM (DMSO)87,00€TPX-0046
CAS:TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.Formula:C21H21FN6O3Purezza:99.07%Colore e forma:SolidPeso molecolare:424.43GSK3179106
CAS:GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nMFormula:C22H21F4N3O4Purezza:100% - 99.8%Colore e forma:SolidPeso molecolare:467.41
