2-[3,5-Bis(Trifluoromethyl)Phenyl]-N,2-Dimethyl-N-[4-(2-Methylphenyl)-6-Morpholin-4-Yl-Pyridin-3-Yl]Propanamide

CAS:
290296-68-3

Rif. 3D-FB103034

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Informazioni sul prodotto

Nome:2-[3,5-Bis(Trifluoromethyl)Phenyl]-N,2-Dimethyl-N-[4-(2-Methylphenyl)-6-Morpholin-4-Yl-Pyridin-3-Yl]Propanamide

Marchio:Biosynth

Descrizione:2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-morpholin-4-ylpyridin-3-yl]propanamide is a serotonin receptor antagonist that blocks the binding of serotonin to its receptors. It is used in the treatment of chronic cough and emetogenic chemotherapy. Netupitant is also an antagonist of the NK1 receptor and is used in combination with other antiemetics for cancer patients receiving high doses of emetogenic chemotherapy. Netupitant has been shown to have an antidepressant effect, which may be due to its ability to inhibit the release of serotonin from platelets. Netupitant may also cause some side effects such as nausea, vomiting, diarrhea, constipation, or headache. These side effects are usually temporary and can be minimized by taking the drug with food or milk.

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Proprietà chimiche

Peso molecolare:565.55 g/mol

Formula:C₂₉H₂₉F₆N₃O₂

Purezza:Min. 95%

InChI:InChI=1S/C29H29F6N3O2/c1-18-7-5-6-8-22(18)23-16-25(38-9-11-40-12-10-38)36-17-24(23)37(4)26(39)27(2,3)19-13-20(28(30,31)32)15-21(14-19)29(33,34)35/h5-8,13-17H,9-12H2,1-4H3

InChI key:InChIKey=ZGNPLCMMVKCTHM-UHFFFAOYSA-N

SMILES:Cc1ccccc1-c1cc(N2CCOCC2)ncc1N(C)C(=O)C(C)(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

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