![4-(4-Chlorophenyl)-1-[3-[2-(4-Fluorophenyl)-1,3-Dithiolan-2-Yl]Propyl]Piperidin-4-Ol](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FFC101106.webp&w=3840&q=75)
4-(4-Chlorophenyl)-1-[3-[2-(4-Fluorophenyl)-1,3-Dithiolan-2-Yl]Propyl]Piperidin-4-Ol
CAS:
Rif. 3D-FC101106
Informazioni sul prodotto
Nome:4-(4-Chlorophenyl)-1-[3-[2-(4-Fluorophenyl)-1,3-Dithiolan-2-Yl]Propyl]Piperidin-4-Ol
Marchio:Biosynth
Descrizione:4-(4-Chlorophenyl)-1-[3-[2-(4-Fluorophenyl)-1,3-dithiolan-2-yl]propyl]piperidin-4-ol is a potent and selective inhibitor of the human epidermal growth factor receptor 2 (HER2) that blocks the activation of the epidermal growth factor receptor. It has a molecular weight of 514.44 and a calculated radius of 3.67 Å. 4-(4-Chlorophenyl)-1-[3-[2-(4-fluorophenyl)-1,3-dithiolan-2-yl]propyl]piperidin-4-ol binds to the nucleotide binding site on HER2, preventing phosphorylation by protein kinase A and protein kinase B. This inhibition leads to reduced downstream signalling for cell proliferation, differentiation, and survival. This compound also inhibits the production of the "pro"
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Proprietà chimiche
Peso molecolare:452.05 g/mol
Formula:C23H27ClFNOS2
Purezza:Min. 95%
InChI:InChI=1S/C23H27ClFNOS2/c24-20-6-2-18(3-7-20)22(27)11-14-26(15-12-22)13-1-10-23(28-16-17-29-23)19-4-8-21(25)9-5-19/h2-9,27H,1,10-17H2
InChI key:InChIKey=KVDKNVPAAQKHKD-UHFFFAOYSA-N
SMILES:OC1(c2ccc(Cl)cc2)CCN(CCCC2(c3ccc(F)cc3)SCCS2)CC1