(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
CAS:
Ref. 3D-AHA55612
100mg
915.00€
250mg
1,403.00€
Product Information
Name:(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
Brand:Biosynth
Description:(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide is a non-peptide antagonist of endothelin A (ET A ) and endothelin B (ET B ). It has been shown to have a high selectivity for ET A over ET B , with potency at concentrations of 1 nM for ET A and 100 nM for ET B . This compound has been shown to inhibit the release of vasoconstrictive endothelin from cultured human endothelial cells. The inhibition is concentration dependent, with shifts in the concentration-response curves being observed as low as 10 μM. The inhibition of release was characterised by clarifying the mechanism involved.
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Chemical properties
Molecular weight:609.7 g/mol
Formula:C31H35N3O8S
Purity:Min. 95%
Technical inquiry about: (R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
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