Product Information
Name:WM 8014
Synonyms:
- MOZ-IN-3
Brand:Biosynth
Description:Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values of 8 nM and 28 nM, respectively. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and potentiates senescence in vitro and in zebrafish model of hepatocellular carcinoma. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:384.43 g/mol
Formula:C20H17FN2O3S
Purity:Min. 95%
Color/Form:Powder
InChI:InChI=1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24)
InChI key:InChIKey=PHHZKBMVRPULAW-UHFFFAOYSA-N
SMILES:Cc1cc(-c2ccccc2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F
Technical inquiry about: WM 8014
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